Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with all data for entry = 50019443
TargetReplicase polyprotein 1ab(2019-nCoV)
Shandong University

Curated by ChEMBL
LigandPNGBDBM420296(med.21724, Compound 61 | peptidomimetic aldehydes ...)
Affinity DataIC50: 53nMAssay Description:Inhibition of SARS-CoV-2 MProMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shandong University

Curated by ChEMBL
LigandPNGBDBM419133(GC376 | BDBM429386 | US12180156, BS of GC373)
Affinity DataIC50: 190nMAssay Description:Inhibition of his-tagged SARS-CoV-2 MPro expressed in Escherichia coli BL21 (DE3) using Abz-SVTLQSG-Y(NO2)-R as substrate incubated for 10 mins by FR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50055218(1-(2-naphthlmethyl) isatin-5-carboxamide | 1-Napht...)
Affinity DataIC50: 300nMAssay Description:Inhibition of SARS-CoV-2 MPro using MCAAVLQSGFR-Lys(Dnp)-Lys-NH2 as substrate incubated for 10 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50619308(CHEMBL5415051)
Affinity DataIC50: 440nMAssay Description:Inhibition of SARS-CoV-2 MPro using MCAAVLQSGFR-Lys(Dnp)-Lys-NH2 as substrate incubated for 10 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50619310(CHEMBL5397586)
Affinity DataIC50: 530nMAssay Description:Inhibition of SARS-CoV-2 MPro using MCAAVLQSGFR-Lys(Dnp)-Lys-NH2 as substrate incubated for 10 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shandong University

Curated by ChEMBL
LigandPNGBDBM682816(US20240208970, Compound 15 | 2-(2-chlorophenyl)-7-...)
Affinity DataIC50: 770nMAssay Description:Inhibition of SARS-CoV-2 MProMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50619309(CHEMBL5421800)
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of SARS-CoV-2 MPro using MCAAVLQSGFR-Lys(Dnp)-Lys-NH2 as substrate incubated for 10 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shandong University

Curated by ChEMBL
LigandPNGBDBM420298(WO2005113580-Ex-02 | PF-00835231 | PF-0835231 | cm...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of SARS-CoV-2 MPro assessed as inhibition constant by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shandong University

Curated by ChEMBL
LigandPNGBDBM496902(PF-07321332 | science.abl4784, 6 | WO2021250648, E...)
Affinity DataKi:  3nMAssay Description:Inhibition of SARS-CoV-2 MProMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed