Compile Data Set for Download or QSAR
Report error Found 17 Enz. Inhib. hit(s) with all data for entry = 50037121
TargetTyrosine-protein kinase Lck(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50111444(2-{4-[2-[1-(4-Methoxy-benzyl)-4-methyl-2-oxo-1,2-d...)
Affinity DataEC50:  1.00E+4nMAssay Description:Inhibition of calcium release in Jurkat cells after T-cell receptor cross linking antibody treatmentMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50111444(2-{4-[2-[1-(4-Methoxy-benzyl)-4-methyl-2-oxo-1,2-d...)
Affinity DataKd:  1.00E+3nMAssay Description:Inhibition of p56 Lck SH2 domain binding to pYEEIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50111444(2-{4-[2-[1-(4-Methoxy-benzyl)-4-methyl-2-oxo-1,2-d...)
Affinity DataKd:  1.00E+3nMAssay Description:Binding affinity for p56 lck kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50111438(3-{[(Benzo[1,3]dioxol-5-ylmethyl)-carbamoyl]-methy...)
Affinity DataIC50: 0.600nMAssay Description:Inhibitory activity against the partially purified human Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50111448(N-Benzo[1,3]dioxol-5-ylmethyl-2-[1-(6-chloro-2-imi...)
Affinity DataIC50: 1.10nMAssay Description:Inhibitory activity against the partially purified human Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50088301((E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-be...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of chemotactic protein to CCR5More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50078347([(S)-1-[1-((1R,6S)-6-Carbamoyl-cyclohex-2-enylcarb...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of Grb2-SH2 domain binding to phospho-EGF receptor intracellular C-terminal domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione S-transferase A2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50111440(Ac-Phe-Met-Aib-Pmp-6-Cl-Trp-Glu-Ac3c-Leu-NH2, GST-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of p53 binding to Glutathione S-transferase 2 (hdm2-GST)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50088301((E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-be...)
Affinity DataIC50: 27nMAssay Description:Inhibition of chemotactic protein to CCR2bMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50111441([1-[1-(6-Carbamoyl-cyclohex-2-enylcarbamoyl)-cyclo...)
Affinity DataIC50: 50nMAssay Description:Inhibition of Growth factor receptor bound protein 2 SH2-domain bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50111445((S)-N-((3R,6S,9S,15S,20aS)-6-((1H-indol-3-yl)methy...)
Affinity DataIC50: 300nMAssay Description:Antagonist activity against the C5a receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50111439({4-[2-Acetylamino-2-(3-carbamoyl-2-cyclohexylmetho...)
Affinity DataIC50: 300nMAssay Description:Inhibition of Src protein tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50111443(2-(2-Hydroxy-ethylamino)-5-nitro-benzo[de]isoquino...)
Affinity DataIC50: 3.72E+3nMAssay Description:Competitive binding against Nerve growth factor to p75-NGF receptor in PC12 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50111443(2-(2-Hydroxy-ethylamino)-5-nitro-benzo[de]isoquino...)
Affinity DataIC50: 3.72E+3nMAssay Description:Inhibition of NGF-stimulated Trk AMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50111437(4-[2-Acetylamino-2-(3-carbamoyl-2-cyclohexylmethox...)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of binding to Src SH2 domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50111443(2-(2-Hydroxy-ethylamino)-5-nitro-benzo[de]isoquino...)
Affinity DataIC50: 5.88E+3nMAssay Description:Inhibition of NGF-stimulated Trk AMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50111438(3-{[(Benzo[1,3]dioxol-5-ylmethyl)-carbamoyl]-methy...)
Affinity DataKi:  2.20nMAssay Description:Binding against the partially purified human Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed