Compile Data Set for Download or QSAR
Report error Found 34 Enz. Inhib. hit(s) with all data for entry = 50049179
TargetEukaryotic initiation factor 4A-III(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50235737(CHEMBL4070102)
Affinity DataKd:  62nMAssay Description:Binding affinity to full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 expressed in Escherichia coli BL21(DE3) by isothermal titration ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic initiation factor 4A-III(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50235739(CHEMBL4079731)
Affinity DataKd:  5.40E+3nMAssay Description:Binding affinity to full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 expressed in Escherichia coli BL21(DE3) administered for 60 to 1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic initiation factor 4A-III(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50235737(CHEMBL4070102)
Affinity DataKd:  200nMAssay Description:Binding affinity to full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 expressed in Escherichia coli BL21(DE3) administered for 60 to 1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic initiation factor 4A-III(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50235738(Hippuristanol)
Affinity DataKd:  5.00E+4nMAssay Description:Binding affinity to full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 expressed in Escherichia coli BL21(DE3) administered for 60 to 1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic initiation factor 4A-III(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50235737(CHEMBL4070102)
Affinity DataIC50: 360nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 expressed in Escherichia coli BL21(DE3) using 1.5 ug/ml ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic initiation factor 4A-III(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50235737(CHEMBL4070102)
Affinity DataIC50: 970nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic initiation factor 4A-III(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50235741(CHEMBL4099717)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic initiation factor 4A-I(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50235738(Hippuristanol)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of eIF4G-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A1 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic initiation factor 4A-III(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50235795(CHEMBL4089069)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic initiation factor 4A-III(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50235740(CHEMBL4061441)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic initiation factor 4A-II(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50235738(Hippuristanol)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of eIF4G-induced eIF4A2 (unknown origin) RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) using single stranded poly(...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic initiation factor 4A-III(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50235794(CHEMBL4067856)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic initiation factor 4A-III(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50235739(CHEMBL4079731)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic initiation factor 4A-III(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50235792(CHEMBL4101109)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic initiation factor 4A-III(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50235796(CHEMBL4081704)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetU5 small nuclear ribonucleoprotein 200 kDa helicase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50235738(Hippuristanol)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 insect cel...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent RNA helicase DHX29(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50235738(Hippuristanol)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of full length recombinant human N-terminal FLAG-His-tagged DHX29 RNA dependent ATPase activity expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic initiation factor 4A-III(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50235738(Hippuristanol)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic initiation factor 4A-III(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50235791(CHEMBL4084655)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic initiation factor 4A-III(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50235797(CHEMBL4089574)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetU5 small nuclear ribonucleoprotein 200 kDa helicase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50235737(CHEMBL4070102)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 insect cel...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic initiation factor 4A-I(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50235740(CHEMBL4061441)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of eIF4G-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A1 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic initiation factor 4A-I(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50235737(CHEMBL4070102)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of eIF4G-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A1 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic initiation factor 4A-I(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50235741(CHEMBL4099717)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of eIF4G-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A1 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic initiation factor 4A-III(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50235793(CHEMBL4074367)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic initiation factor 4A-III(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50235742(CHEMBL4082138)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent RNA helicase DHX29(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50235737(CHEMBL4070102)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of full length recombinant human N-terminal FLAG-His-tagged DHX29 RNA dependent ATPase activity expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic initiation factor 4A-III(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50235790(CHEMBL4062984)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic initiation factor 4A-III(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50235789(CHEMBL4075940)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic initiation factor 4A-III(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50235744(CHEMBL4071613)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic initiation factor 4A-III(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50235743(CHEMBL23134)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic initiation factor 4A-III(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305666(6-methyl-1H-indole-2-carboxylic acid | CHEMBL59600...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic initiation factor 4A-II(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50235737(CHEMBL4070102)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of eIF4G-induced eIF4A2 (unknown origin) RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) using single stranded poly(...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic initiation factor 4A-III(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50235737(CHEMBL4070102)
Affinity DataKi:  430nMAssay Description:ATP competitive inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 expressed in Escherichia coli BL21(DE3) ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed