Compile Data Set for Download or QSAR
Report error Found 37 Enz. Inhib. hit(s) with all data for entry = 50049199
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Rat)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50236225(CHEMBL4074744 | US11186582, Example 269 | US114198...)
Affinity DataEC50:  670nMAssay Description:Inhibition of PDE2a in rat primary cortical neurons assessed as increase in Bay 41-8543-stimulated intracellular cGMP level preincubated for 30 mins ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50236228(CHEMBL4076035 | US11186582, Example 6)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM107767(US8598155, 2 | US11419874, PF-05180999)
Affinity DataIC50: 1nMAssay Description:Inhibition of human full length PDE2a using cGMP as substrate by Scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50236235(CHEMBL4066029 | US11186582, Example 4)
Affinity DataIC50: 1nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50236271(CHEMBL4103411 | US11186582, Example 225)
Affinity DataIC50: 1nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50166893(2-(3,4-Dimethoxy-benzyl)-7-[(R)-1-((R)-1-hydroxy-e...)
Affinity DataIC50: 2nMAssay Description:Inhibition of PDE2a (unknown origin) using cAMP as substrate after 30 mins by Scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50236231(CHEMBL4087945 | US11186582, Example 349 | US114198...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50236243(CHEMBL4059930 | US11186582, Example 340)
Affinity DataIC50: 2nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50236226(CHEMBL4087412 | US11186582, Example 378 | US114198...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50236242(CHEMBL4093237 | US11186582, Example 516)
Affinity DataIC50: 3nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50236236(CHEMBL4095099 | US11186582, Example 5)
Affinity DataIC50: 7nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50236225(CHEMBL4074744 | US11186582, Example 269 | US114198...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50236241(CHEMBL4069050 | US11186582, Example 481)
Affinity DataIC50: 10nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50236275(CHEMBL4081851 | US11186582, Example 235)
Affinity DataIC50: 14nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50236233(CHEMBL4077469 | US11186582, Example 319)
Affinity DataIC50: 23nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50236239(CHEMBL4095653 | US11186582, Example 338)
Affinity DataIC50: 47nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50236244(CHEMBL4065588 | US11186582, Example 268)
Affinity DataIC50: 52nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50236276(CHEMBL4082820 | US11186582, Example 239)
Affinity DataIC50: 52nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50236232(CHEMBL4062668 | US11186582, Example 309)
Affinity DataIC50: 62nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50236273(CHEMBL4066638 | US11186582, Example 475)
Affinity DataIC50: 80nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50236229(CHEMBL4074644)
Affinity DataIC50: 140nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50236227(CHEMBL1482245)
Affinity DataIC50: 170nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50236272(CHEMBL4102860)
Affinity DataIC50: 210nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50236274(CHEMBL4090625 | US11186582, Example 246)
Affinity DataIC50: 679nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50236277(CHEMBL4100798 | US11186582, Example 244)
Affinity DataIC50: 987nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50236245(CHEMBL4064972)
Affinity DataIC50: 1.52E+3nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50236225(CHEMBL4074744 | US11186582, Example 269 | US114198...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of PDE10A1 (unknown origin) using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured after 30 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50236234(CHEMBL4084910)
Affinity DataIC50: 5.36E+3nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50236225(CHEMBL4074744 | US11186582, Example 269 | US114198...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE6C (unknown origin) expressed in Baculovirus infected Sf9 insect cells using cGMP as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50236225(CHEMBL4074744 | US11186582, Example 269 | US114198...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE7A (unknown origin) using fluorescently labeled cAMP as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50236225(CHEMBL4074744 | US11186582, Example 269 | US114198...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human full length N-terminal GST-tagged PDE8A1 expressed in Baculovirus infected Sf9 insect cells using cAMP as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50236225(CHEMBL4074744 | US11186582, Example 269 | US114198...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE5A1 (unknown origin) expressed in Baculovirus infected Sf9 insect cells using fluorescently labeled cGMP as substrate by fluorescenc...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50236225(CHEMBL4074744 | US11186582, Example 269 | US114198...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE1B (unknown origin) using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured after 30 min...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50236225(CHEMBL4074744 | US11186582, Example 269 | US114198...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human full length N-terminal GST-tagged PDE11A4 expressed in Baculovirus infected Sf9 insect cells using cAMP as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50236225(CHEMBL4074744 | US11186582, Example 269 | US114198...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human full length N-terminal GST-tagged PDE9A2 expressed in Baculovirus infected Sf9 insect cells using cGMP as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50236225(CHEMBL4074744 | US11186582, Example 269 | US114198...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE4D3 (unknown origin) using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured after 30 mi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50236225(CHEMBL4074744 | US11186582, Example 269 | US114198...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE3A (unknown origin) using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured after 30 min...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed