Compile Data Set for Download or QSAR
Report error Found 216 of ph data with Target = 'ALK tyrosine kinase receptor'
TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM21079(1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluora...)
Affinity DataKd:  1.60E+3nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd:  1.40E+3nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM25118(4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...)
Affinity DataKd:  3.50E+3nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM31090((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...)
Affinity DataKd:  7.10E+3nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataKd:  1.20E+3nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM31099(CHEMBL45741 | Flavopiridol | cid_24867231 | 2-(2-c...)
Affinity DataKd:  670nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM26474(GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...)
Affinity DataKd:  2.20E+3nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataKd:  7.10E+3nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM31094(PKC-412 | cid_24202429)
Affinity DataKd:  270nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM7533(2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...)
Affinity DataKd:  2.30E+3nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  490nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM31096(CHEMBL290084 | Staurosporine | cid_451705 | US2024...)
Affinity DataKd:  32nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  170nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataKd:  3.10E+3nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM21(VANDETANIB | N-(4-bromo-2-fluorophenyl)-6-methoxy-...)
Affinity DataKd:  2.10E+3nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataIC50: 17.3nMpH: 7.5 T: 2°CAssay Description:The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2016
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM179803(3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(pi...)
Affinity DataIC50: 17.6nMpH: 7.5 T: 2°CAssay Description:The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2016
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM245230(US9428500, 24)
Affinity DataIC50: 52nMpH: 7.5 T: 2°CAssay Description:GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
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TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 55nMpH: 7.5Assay Description:ALK enzyme needs pre-activation in order to linearize reaction kinetics.Kinase Buffer (KB) for ALKKinase buffer was composed of 50 mM HEPES pH 7.5 co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2015
Entry Details
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PDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM245218(US9428500, 12)
Affinity DataIC50: 110nMpH: 7.5 T: 2°CAssay Description:GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
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TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM179801(3-((2,6-dichloro-3-fluorophenyl)thio)-5-(1-(piperi...)
Affinity DataIC50: 135nMpH: 7.5 T: 2°CAssay Description:The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2016
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM245235(US9428500, 29)
Affinity DataIC50: 160nMpH: 7.5 T: 2°CAssay Description:GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
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TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM245243(US9428500, 37)
Affinity DataIC50: 170nMpH: 7.5 T: 2°CAssay Description:GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM245222(US9428500, 16)
Affinity DataIC50: 200nMpH: 7.5 T: 2°CAssay Description:GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
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TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM245264(US9428500, 58)
Affinity DataIC50: 200nMpH: 7.5 T: 2°CAssay Description:GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
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TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM261671(4-((4-methylpiperazin-1-yl)methyl)-N-(4-(3-((triis...)
Affinity DataIC50: 200nMpH: 7.5 T: 2°CAssay Description:GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM158155(US9029356, 4 | US9255087, 4 | US10081622, Compound...)
Affinity DataIC50: 207nMpH: 7.5Assay Description:ALK enzyme needs pre-activation in order to linearize reaction kinetics.Kinase Buffer (KB) for ALKKinase buffer was composed of 50 mM HEPES pH 7.5 co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2015
Entry Details
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TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM245223(US9428500, 17)
Affinity DataIC50: 210nMpH: 7.5 T: 2°CAssay Description:GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM179800(3-((2,6-dichloro-3-fluorophenyl)sulfide)-5-(1-(pip...)
Affinity DataIC50: 214nMpH: 7.5 T: 2°CAssay Description:The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2016
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM245212(US9428500, 6)
Affinity DataIC50: 250nMpH: 7.5 T: 2°CAssay Description:GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM245217(US9428500, 11)
Affinity DataIC50: 260nMpH: 7.5 T: 2°CAssay Description:GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM245234(US9428500, 28)
Affinity DataIC50: 270nMpH: 7.5 T: 2°CAssay Description:GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM125913(US8765727, 16)
Affinity DataIC50: 280nMpH: 7.8Assay Description:HTRF kinase assay: 40 μL reactions were run in black 384 well polystyrene plates in assay buffer (50 mM Tris, pH 7.8, 100 mM NaCI, 0.1 mg/mL BSA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2014
Entry Details
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TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM245220(US9428500, 14)
Affinity DataIC50: 280nMpH: 7.5 T: 2°CAssay Description:GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM245258(US9428500, 52)
Affinity DataIC50: 310nMpH: 7.5 T: 2°CAssay Description:GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM245216(US9428500, 10)
Affinity DataIC50: 320nMpH: 7.5 T: 2°CAssay Description:GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
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TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM245210(US9428500, 4)
Affinity DataIC50: 350nMpH: 7.5 T: 2°CAssay Description:GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
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TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM245219(US9428500, 13)
Affinity DataIC50: 370nMpH: 7.5 T: 2°CAssay Description:GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
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TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM179804(3-{[1-(2,6-dichloro-3-fluorophenyl)ethyl]sulfanyl}...)
Affinity DataIC50: 372nMpH: 7.5 T: 2°CAssay Description:The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2016
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM261652(5-(4-(4-methylpiperazine-1-carbonyl)phenyl)-N-(4-(...)
Affinity DataIC50: 385nMpH: 7.5 T: 2°CAssay Description:GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM158156(US9029356, 26 | US9255087, 26 | US10081622, Compou...)
Affinity DataIC50: 411nMpH: 7.5Assay Description:ALK enzyme needs pre-activation in order to linearize reaction kinetics.Kinase Buffer (KB) for ALKKinase buffer was composed of 50 mM HEPES pH 7.5 co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2015
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM261649(5-(4-(4-methylpiperazine-1-carbonyl)phenyl)-N-(4-(...)
Affinity DataIC50: 420nMpH: 7.5 T: 2°CAssay Description:GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
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TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM261650(N-(4-(3-((tert-butyldimethylsilyl)ethynyl)phenyl)t...)
Affinity DataIC50: 428nMpH: 7.5 T: 2°CAssay Description:GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
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TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM245224(US9428500, 18)
Affinity DataIC50: 460nMpH: 7.5 T: 2°CAssay Description:GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
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TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM245208(US9428500, 2)
Affinity DataIC50: 500nMpH: 7.5 T: 2°CAssay Description:GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
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TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM179798(3-(1-(2,6-dichloro-3-fluorophenyl)ethyl)-2-methyl-...)
Affinity DataIC50: 504nMpH: 7.5 T: 2°CAssay Description:The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2016
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM179802(3-(1-(2,6-dichloro-3-fluorophenyl)cyclopropyl)-5-(...)
Affinity DataIC50: 508nMpH: 7.5 T: 2°CAssay Description:The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2016
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM245232(US9428500, 26)
Affinity DataIC50: 520nMpH: 7.5 T: 2°CAssay Description:GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
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TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM261639(N-(4-(3,4-bis((triisopropylsilyl)ethynyl)phenyl)th...)
Affinity DataIC50: 540nMpH: 7.5 T: 2°CAssay Description:GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
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TargetALK tyrosine kinase receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM245240(US9428500, 35 | US9428500, 34)
Affinity DataIC50: 560nMpH: 7.5 T: 2°CAssay Description:GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
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