Affinity DataIC50: 1.40nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
Affinity DataIC50: 2.80nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
Affinity DataIC50: 2.90nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
Affinity DataIC50: 4.5nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
Affinity DataIC50: 4.90nMpH: 7.0 T: 2°CAssay Description:Inhibition assay using gamma-secretase.More data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
Affinity DataIC50: 5.80nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
Affinity DataIC50: 6.10nMpH: 7.0 T: 2°CAssay Description:Inhibition assay using gamma-secretase.More data for this Ligand-Target Pair
Affinity DataIC50: 6.40nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
Affinity DataIC50: 6.60nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
Affinity DataIC50: 7.20nMpH: 7.0 T: 2°CAssay Description:Inhibition assay using gamma-secretase.More data for this Ligand-Target Pair
Affinity DataIC50: 7.30nMpH: 7.0 T: 2°CAssay Description:Inhibition assay using gamma-secretase.More data for this Ligand-Target Pair
Affinity DataIC50: 7.5nMpH: 7.0 T: 2°CAssay Description:Inhibition assay using gamma-secretase.More data for this Ligand-Target Pair
Affinity DataIC50: 8.20nMpH: 7.0 T: 2°CAssay Description:Inhibition assay using gamma-secretase.More data for this Ligand-Target Pair
Affinity DataIC50: 9.80nMpH: 7.0 T: 2°CAssay Description:Inhibition assay using gamma-secretase.More data for this Ligand-Target Pair
Affinity DataIC50: 10.2nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
Affinity DataIC50: 12.9nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
Affinity DataIC50: 16.5nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
Affinity DataIC50: 18.7nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
Affinity DataIC50: 130nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
Affinity DataIC50: 140nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
Affinity DataIC50: 140nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
Affinity DataIC50: 210nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
Affinity DataIC50: 300nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
Affinity DataIC50: 310nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
Affinity DataIC50: 310nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
Affinity DataIC50: 320nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
Affinity DataIC50: 360nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
Affinity DataIC50: 380nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
Affinity DataIC50: 440nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
Affinity DataIC50: 500nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
Affinity DataIC50: 500nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
Affinity DataIC50: 520nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
Affinity DataIC50: 560nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
Affinity DataIC50: 650nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
Affinity DataIC50: 650nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
Affinity DataIC50: 700nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
Affinity DataIC50: 800nMpH: 7.0Assay Description:The assay protocol employed was a modified version of that described in Li et al., 2000, Proc. Nat'l Acad. Sci. USA 97:6183-643, incorporated her...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMpH: 7.0Assay Description:The assay protocol employed was a modified version of that described in Li et al., 2000, Proc. Nat'l Acad. Sci. USA 97:6183-643, incorporated her...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMpH: 8.0 T: 2°CAssay Description:In this assay, assembly of Abeta 1-42 oligomer formation is monitored by FRET using N-terminal conjugates of fluorescein-Abeta 1-42 as both the donor...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
Affinity DataIC50: 3.20E+3nMpH: 8.0 T: 2°CAssay Description:In this assay, assembly of Abeta 1-42 oligomer formation is monitored by FRET using N-terminal conjugates of fluorescein-Abeta 1-42 as both the donor...More data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+3nMpH: 8.0 T: 2°CAssay Description:In this assay, assembly of Abeta 1-42 oligomer formation is monitored by FRET using N-terminal conjugates of fluorescein-Abeta 1-42 as both the donor...More data for this Ligand-Target Pair
Affinity DataIC50: 3.80E+3nMpH: 8.0 T: 2°CAssay Description:In this assay, assembly of Abeta 1-42 oligomer formation is monitored by FRET using N-terminal conjugates of fluorescein-Abeta 1-42 as both the donor...More data for this Ligand-Target Pair
Affinity DataIC50: 3.90E+3nMpH: 8.0 T: 2°CAssay Description:In this assay, assembly of Abeta 1-42 oligomer formation is monitored by FRET using N-terminal conjugates of fluorescein-Abeta 1-42 as both the donor...More data for this Ligand-Target Pair
Affinity DataIC50: 4.40E+3nMpH: 8.0 T: 2°CAssay Description:In this assay, assembly of Abeta 1-42 oligomer formation is monitored by FRET using N-terminal conjugates of fluorescein-Abeta 1-42 as both the donor...More data for this Ligand-Target Pair