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Report error Found 67 of ph data with Target = 'Amyloid-beta precursor protein'
TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM200301(US9226927, 4)
Affinity DataIC50: 1.40nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
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TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM200304(US9226927, 11)
Affinity DataIC50: 1.70nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
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TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM200302(US9226927, 8a)
Affinity DataIC50: 1.90nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
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TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM200314(US9226927, 27a)
Affinity DataIC50: 2.80nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
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TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM200311(US9226927, 25f)
Affinity DataIC50: 2.90nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
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TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM200307(US9226927, 25b)
Affinity DataIC50: 4.5nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
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TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM93325(Carbamate {3,21}, 1)
Affinity DataIC50: 4.90nMpH: 7.0 T: 2°CAssay Description:Inhibition assay using gamma-secretase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2013
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM200308(US9226927, 25c)
Affinity DataIC50: 5.5nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
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TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM200305(US9226927, 14)
Affinity DataIC50: 5.80nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
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TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM93326(Carbamate {3,19}, 2)
Affinity DataIC50: 6.10nMpH: 7.0 T: 2°CAssay Description:Inhibition assay using gamma-secretase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2013
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM200310(US9226927, 25e)
Affinity DataIC50: 6.40nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
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TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM200303(US9226927, 8b)
Affinity DataIC50: 6.60nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
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TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM93327(Carbamate {5,21}, 3)
Affinity DataIC50: 7.20nMpH: 7.0 T: 2°CAssay Description:Inhibition assay using gamma-secretase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2013
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM93328(Carbamate {3,17}, 4)
Affinity DataIC50: 7.30nMpH: 7.0 T: 2°CAssay Description:Inhibition assay using gamma-secretase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2013
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM93329(Carbamate {5,19}, 5)
Affinity DataIC50: 7.5nMpH: 7.0 T: 2°CAssay Description:Inhibition assay using gamma-secretase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2013
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM93330(Carbamate {1,21}, 6)
Affinity DataIC50: 8.20nMpH: 7.0 T: 2°CAssay Description:Inhibition assay using gamma-secretase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2013
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM93331(Carbamate {3,13}, 7)
Affinity DataIC50: 9.80nMpH: 7.0 T: 2°CAssay Description:Inhibition assay using gamma-secretase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2013
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM200309(US9226927, 25d)
Affinity DataIC50: 10.2nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
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TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM200312(US9226927, 25g)
Affinity DataIC50: 12.9nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
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TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM200313(US9226927, 25h)
Affinity DataIC50: 16.5nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
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TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM200315(US9226927, 27b)
Affinity DataIC50: 18nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
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TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM200306(US9226927, 25a)
Affinity DataIC50: 18.7nMpH: 7.0 T: 2°CAssay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
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TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM145857(US8956589, 29)
Affinity DataIC50: 100nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2015
Entry Details
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TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM145855(US8956589, 27)
Affinity DataIC50: 130nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2015
Entry Details
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TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM145848(US8956589, 7)
Affinity DataIC50: 140nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2015
Entry Details
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TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM145853(US8956589, 25)
Affinity DataIC50: 140nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2015
Entry Details
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TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM145840(US8956589, 23)
Affinity DataIC50: 210nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2015
Entry Details
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TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM145859(US8956589, 15)
Affinity DataIC50: 300nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2015
Entry Details
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TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM145854(US8956589, 26)
Affinity DataIC50: 310nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2015
Entry Details
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TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM145844(US8956589, 6)
Affinity DataIC50: 310nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2015
Entry Details
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TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM145860(US8956589, 16)
Affinity DataIC50: 320nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2015
Entry Details
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TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM145858(US8956589, 14)
Affinity DataIC50: 360nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2015
Entry Details
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TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM145845(US8956589, 8)
Affinity DataIC50: 380nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2015
Entry Details
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TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM145841(US8956589, 1)
Affinity DataIC50: 440nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2015
Entry Details
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TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM145850(US8956589, 20)
Affinity DataIC50: 500nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2015
Entry Details
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TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM145851(US8956589, 21)
Affinity DataIC50: 500nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2015
Entry Details
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TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM145843(US8956589, 5)
Affinity DataIC50: 520nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2015
Entry Details
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TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM145849(US8956589, 19)
Affinity DataIC50: 560nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2015
Entry Details
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TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM145846(US8956589, 9)
Affinity DataIC50: 650nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2015
Entry Details
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TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM145861(US8956589, 30)
Affinity DataIC50: 650nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2015
Entry Details
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TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM145852(US8956589, 22)
Affinity DataIC50: 700nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2015
Entry Details
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TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM162704(US9056857, 11)
Affinity DataIC50: 800nMpH: 7.0Assay Description:The assay protocol employed was a modified version of that described in Li et al., 2000, Proc. Nat'l Acad. Sci. USA 97:6183-643, incorporated her...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2016
Entry Details
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TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM162703(US9056857, 5)
Affinity DataIC50: 1.00E+3nMpH: 7.0Assay Description:The assay protocol employed was a modified version of that described in Li et al., 2000, Proc. Nat'l Acad. Sci. USA 97:6183-643, incorporated her...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2016
Entry Details
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TargetAmyloid-beta precursor protein(Rat)
Acumen Pharmaceuticals

US Patent
LigandPNGBDBM155394(US9006283, 4)
Affinity DataIC50: 1.10E+3nMpH: 8.0 T: 2°CAssay Description:In this assay, assembly of Abeta 1-42 oligomer formation is monitored by FRET using N-terminal conjugates of fluorescein-Abeta 1-42 as both the donor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2015
Entry Details
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TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM145847(US8956589, 2)
Affinity DataIC50: 1.30E+3nMpH: 7.5 T: 2°CAssay Description:First, amyloid beta peptides (1-40, Peptide Institute, Minoh-shi, Osaka) were dissolved in a 50 mM phosphate buffer containing 100 mM sodium chloride...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2015
Entry Details
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TargetAmyloid-beta precursor protein(Rat)
Acumen Pharmaceuticals

US Patent
LigandPNGBDBM155395(US9006283, 5)
Affinity DataIC50: 3.20E+3nMpH: 8.0 T: 2°CAssay Description:In this assay, assembly of Abeta 1-42 oligomer formation is monitored by FRET using N-terminal conjugates of fluorescein-Abeta 1-42 as both the donor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2015
Entry Details
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TargetAmyloid-beta precursor protein(Rat)
Acumen Pharmaceuticals

US Patent
LigandPNGBDBM155392(US9006283, 2)
Affinity DataIC50: 3.50E+3nMpH: 8.0 T: 2°CAssay Description:In this assay, assembly of Abeta 1-42 oligomer formation is monitored by FRET using N-terminal conjugates of fluorescein-Abeta 1-42 as both the donor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2015
Entry Details
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TargetAmyloid-beta precursor protein(Rat)
Acumen Pharmaceuticals

US Patent
LigandPNGBDBM155396(US9006283, 6)
Affinity DataIC50: 3.80E+3nMpH: 8.0 T: 2°CAssay Description:In this assay, assembly of Abeta 1-42 oligomer formation is monitored by FRET using N-terminal conjugates of fluorescein-Abeta 1-42 as both the donor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2015
Entry Details
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TargetAmyloid-beta precursor protein(Rat)
Acumen Pharmaceuticals

US Patent
LigandPNGBDBM155391(US9006283, 1)
Affinity DataIC50: 3.90E+3nMpH: 8.0 T: 2°CAssay Description:In this assay, assembly of Abeta 1-42 oligomer formation is monitored by FRET using N-terminal conjugates of fluorescein-Abeta 1-42 as both the donor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2015
Entry Details
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TargetAmyloid-beta precursor protein(Rat)
Acumen Pharmaceuticals

US Patent
LigandPNGBDBM155393(US9006283, 3)
Affinity DataIC50: 4.40E+3nMpH: 8.0 T: 2°CAssay Description:In this assay, assembly of Abeta 1-42 oligomer formation is monitored by FRET using N-terminal conjugates of fluorescein-Abeta 1-42 as both the donor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2015
Entry Details
Go to US Patent

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