Compile Data Set for Download or QSAR
Report error Found 353 of ph data with Target = 'Aurora kinase A'
TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 12407BDBM12407(CHEMBL205877 | 3-chloro-N-[5-({6-methoxy-7-[3-(mor...)
Affinity DataIC50: 0.100nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora A purified from Sf9 cells, was incubated at room temperature with substrate, and test compounds in the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2006
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 12408BDBM12408(3-chloro-4-fluoro-N-[5-({6-methoxy-7-[3-(morpholin...)
Affinity DataIC50: 0.150nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora A purified from Sf9 cells, was incubated at room temperature with substrate, and test compounds in the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2006
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 155565BDBM155565(US9012475, 1 | US9346787, 1 | US10092556, Example ...)
Affinity DataIC50: 0.400nMpH: 7.4 T: 2°CAssay Description:An inhibitory activity of the above compound in-vitro against Aurora A kinase activity was measured with reference to a method described in JP-A-2008...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 155568BDBM155568(US9012475, 12 | US9346787, 12 | US10092556, Exampl...)
Affinity DataIC50: 0.400nMpH: 7.4 T: 2°CAssay Description:An inhibitory activity of the above compound in-vitro against Aurora A kinase activity was measured with reference to a method described in JP-A-2008...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 155565BDBM155565(US9012475, 1 | US9346787, 1 | US10092556, Example ...)
Affinity DataIC50: 0.400nMpH: 7.4 T: 2°CAssay Description:For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2019
Entry Details
US Patent

TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 155568BDBM155568(US9012475, 12 | US9346787, 12 | US10092556, Exampl...)
Affinity DataIC50: 0.400nMpH: 7.4 T: 2°CAssay Description:For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
US Patent

TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 155569BDBM155569(US9012475, 13 | US9346787, 13 | US10092556, Exampl...)
Affinity DataIC50: 0.400nMpH: 7.4 T: 2°CAssay Description:For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
US Patent

TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 155565BDBM155565(US9012475, 1 | US9346787, 1 | US10092556, Example ...)
Affinity DataIC50: 0.400nMpH: 7.4 T: 2°CAssay Description:For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
US Patent

TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 155568BDBM155568(US9012475, 12 | US9346787, 12 | US10092556, Exampl...)
Affinity DataIC50: 0.400nMpH: 7.4 T: 2°CAssay Description:For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2019
Entry Details
US Patent

TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 155569BDBM155569(US9012475, 13 | US9346787, 13 | US10092556, Exampl...)
Affinity DataIC50: 0.400nMpH: 7.4 T: 2°CAssay Description:An inhibitory activity of the above compound in-vitro against Aurora A kinase activity was measured with reference to a method described in JP-A-2008...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 155569BDBM155569(US9012475, 13 | US9346787, 13 | US10092556, Exampl...)
Affinity DataIC50: 0.400nMpH: 7.4 T: 2°CAssay Description:For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2019
Entry Details
US Patent

TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 155566BDBM155566(US9012475, 2 | US9346787, 2 | US10092556, Example ...)
Affinity DataIC50: 0.5nMpH: 7.4 T: 2°CAssay Description:An inhibitory activity of the above compound in-vitro against Aurora A kinase activity was measured with reference to a method described in JP-A-2008...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 155566BDBM155566(US9012475, 2 | US9346787, 2 | US10092556, Example ...)
Affinity DataIC50: 0.5nMpH: 7.4 T: 2°CAssay Description:For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2019
Entry Details
US Patent

TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 155574BDBM155574(US9012475, 24 | US9346787, 24 | US10092556, Exampl...)
Affinity DataIC50: 0.5nMpH: 7.4 T: 2°CAssay Description:For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2019
Entry Details
US Patent

TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 155566BDBM155566(US9012475, 2 | US9346787, 2 | US10092556, Example ...)
Affinity DataIC50: 0.5nMpH: 7.4 T: 2°CAssay Description:For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
US Patent

TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 155574BDBM155574(US9012475, 24 | US9346787, 24 | US10092556, Exampl...)
Affinity DataIC50: 0.5nMpH: 7.4 T: 2°CAssay Description:An inhibitory activity of the above compound in-vitro against Aurora A kinase activity was measured with reference to a method described in JP-A-2008...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 155574BDBM155574(US9012475, 24 | US9346787, 24 | US10092556, Exampl...)
Affinity DataIC50: 0.5nMpH: 7.4 T: 2°CAssay Description:For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
US Patent

TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 155567BDBM155567(US9012475, 11 | US9346787, 11 | US10092556, Exampl...)
Affinity DataIC50: 0.600nMpH: 7.4 T: 2°CAssay Description:An inhibitory activity of the above compound in-vitro against Aurora A kinase activity was measured with reference to a method described in JP-A-2008...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 47238BDBM47238(US9012475, MLN8237)
Affinity DataIC50: 0.600nMpH: 7.4Assay Description:The method for measuring the in-vitro inhibitory activity of a test compound against Aurora B kinase activity was substantially the same as in the ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 13534BDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataKi:  0.600nM ΔG°:  -52.1kJ/molepH: 7.5 T: 2°CAssay Description:The kinase activity was determined by incubation of enzyme and its substrate, and test compound, in the presence ATP/[gamma-32P] ATP. After incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2007
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 155567BDBM155567(US9012475, 11 | US9346787, 11 | US10092556, Exampl...)
Affinity DataIC50: 0.600nMpH: 7.4 T: 2°CAssay Description:For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
US Patent

TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 155567BDBM155567(US9012475, 11 | US9346787, 11 | US10092556, Exampl...)
Affinity DataIC50: 0.600nMpH: 7.4 T: 2°CAssay Description:For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2019
Entry Details
US Patent

TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14192BDBM14192(3-({7-cyclohexyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl}a...)
Affinity DataIC50: 0.600nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14208BDBM14208(3-{[7-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-...)
Affinity DataIC50: 0.600nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 50277545BDBM50277545(Alisertib | MLN8237 | CHEMBL483158 | 4-(9-chloro-7...)
Affinity DataIC50: 0.600nMpH: 7.4 T: 2°CAssay Description:For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
US Patent

TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 13534BDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataIC50: 0.600nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 50277545BDBM50277545(Alisertib | MLN8237 | CHEMBL483158 | 4-(9-chloro-7...)
Affinity DataIC50: 0.600nMpH: 7.4 T: 2°CAssay Description:For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2019
Entry Details
US Patent

TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 155573BDBM155573(US9012475, 22 | US9346787, 22 | US10092556, Exampl...)
Affinity DataIC50: 0.700nMpH: 7.4 T: 2°CAssay Description:For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
US Patent

TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 155573BDBM155573(US9012475, 22 | US9346787, 22 | US10092556, Exampl...)
Affinity DataIC50: 0.700nMpH: 7.4 T: 2°CAssay Description:For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2019
Entry Details
US Patent

TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 155573BDBM155573(US9012475, 22 | US9346787, 22 | US10092556, Exampl...)
Affinity DataIC50: 0.700nMpH: 7.4 T: 2°CAssay Description:An inhibitory activity of the above compound in-vitro against Aurora A kinase activity was measured with reference to a method described in JP-A-2008...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 155575BDBM155575(US9012475, 28 | US9346787, 28 | US10092556, Exampl...)
Affinity DataIC50: 0.700nMpH: 7.4 T: 2°CAssay Description:For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2019
Entry Details
US Patent

TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 155575BDBM155575(US9012475, 28 | US9346787, 28 | US10092556, Exampl...)
Affinity DataIC50: 0.700nMpH: 7.4 T: 2°CAssay Description:An inhibitory activity of the above compound in-vitro against Aurora A kinase activity was measured with reference to a method described in JP-A-2008...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 155575BDBM155575(US9012475, 28 | US9346787, 28 | US10092556, Exampl...)
Affinity DataIC50: 0.700nMpH: 7.4 T: 2°CAssay Description:For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
US Patent

TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14209BDBM14209(4-(4-{[7-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin...)
Affinity DataIC50: 0.800nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 155576BDBM155576(US9012475, 29 | US9346787, 29 | US10092556, Exampl...)
Affinity DataIC50: 0.800nMpH: 7.4 T: 2°CAssay Description:For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2019
Entry Details
US Patent

TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 155576BDBM155576(US9012475, 29 | US9346787, 29 | US10092556, Exampl...)
Affinity DataIC50: 0.800nMpH: 7.4 T: 2°CAssay Description:An inhibitory activity of the above compound in-vitro against Aurora A kinase activity was measured with reference to a method described in JP-A-2008...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 92800BDBM92800(Bisanilinopyrimidine, 3o | US9249124, 16)
Affinity DataIC50: 0.800nMpH: 7.4 T: 2°CAssay Description:Reactions were carried out at room temperature in 15 mM HEPES buffer (pH 7.4) containing 20 mM NaCl, 1 mM EGTA, 0.02% Tween 20, 10 mM MgCl2, 5% (v/v)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2017
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 155576BDBM155576(US9012475, 29 | US9346787, 29 | US10092556, Exampl...)
Affinity DataIC50: 0.800nMpH: 7.4 T: 2°CAssay Description:For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
US Patent

TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 92800BDBM92800(Bisanilinopyrimidine, 3o | US9249124, 16)
Affinity DataIC50: 0.800nMpH: 7.4 T: 2°CAssay Description:Aurora A was exchanged into 50 mM phosphate buffer (pH 7.4) including 1 mM DTT via PD-10 columns and was concentrated to 20 mg mL-1 using Amicon Ultr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2017
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 155571BDBM155571(US9012475, 17 | US9346787, 17 | US10092556, Exampl...)
Affinity DataIC50: 0.900nMpH: 7.4 T: 2°CAssay Description:For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2019
Entry Details
US Patent

TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 155570BDBM155570(US9012475, 14 | US9346787, 14 | US10092556, Exampl...)
Affinity DataIC50: 0.900nMpH: 7.4 T: 2°CAssay Description:For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
US Patent

TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 155571BDBM155571(US9012475, 17 | US9346787, 17 | US10092556, Exampl...)
Affinity DataIC50: 0.900nMpH: 7.4 T: 2°CAssay Description:For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
US Patent

TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 155570BDBM155570(US9012475, 14 | US9346787, 14 | US10092556, Exampl...)
Affinity DataIC50: 0.900nMpH: 7.4 T: 2°CAssay Description:An inhibitory activity of the above compound in-vitro against Aurora A kinase activity was measured with reference to a method described in JP-A-2008...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 155571BDBM155571(US9012475, 17 | US9346787, 17 | US10092556, Exampl...)
Affinity DataIC50: 0.900nMpH: 7.4 T: 2°CAssay Description:An inhibitory activity of the above compound in-vitro against Aurora A kinase activity was measured with reference to a method described in JP-A-2008...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 155570BDBM155570(US9012475, 14 | US9346787, 14 | US10092556, Exampl...)
Affinity DataIC50: 0.900nMpH: 7.4 T: 2°CAssay Description:For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2019
Entry Details
US Patent

TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 155572BDBM155572(US9012475, 19 | US9346787, 19 | US10092556, Exampl...)
Affinity DataIC50: 1nMpH: 7.4 T: 2°CAssay Description:For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
US Patent

TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 155572BDBM155572(US9012475, 19 | US9346787, 19 | US10092556, Exampl...)
Affinity DataIC50: 1nMpH: 7.4 T: 2°CAssay Description:For in vitro method for measuring the inhibitory activity of the aforementioned compounds on the aurora A kinase activity was carried out referring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2019
Entry Details
US Patent

TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 31093BDBM31093(cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...)
Affinity DataIC50: 1nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 155572BDBM155572(US9012475, 19 | US9346787, 19 | US10092556, Exampl...)
Affinity DataIC50: 1nMpH: 7.4 T: 2°CAssay Description:An inhibitory activity of the above compound in-vitro against Aurora A kinase activity was measured with reference to a method described in JP-A-2008...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2015
Entry Details
US Patent

TargetAurora kinase A(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 13534BDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataIC50: 1.40nMpH: 7.0 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2009
Entry Details Article
PubMed
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