Compile Data Set for Download or QSAR
Report error Found 219 of ph data with Target = 'Cannabinoid receptor 1'
TargetCannabinoid receptor 1(Rat)
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50350429BDBM50350429(CHEMBL1814154)
Affinity DataIC50: 0.100nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50350447BDBM50350447(CHEMBL1814329)
Affinity DataIC50: 0.100nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50350458BDBM50350458(CHEMBL1814333)
Affinity DataIC50: 0.100nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 29098BDBM29098(dibenzothiazepine, 12e)
Affinity DataKi:  0.200nM ΔG°:  -54.8kJ/molepH: 7.2 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 29100BDBM29100(dibenzothiazepine, 12h)
Affinity DataKi:  0.200nM ΔG°:  -54.8kJ/molepH: 7.2 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50200841BDBM50200841(CHEMBL220360 | N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-...)
Affinity DataIC50: 0.300nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 29096BDBM29096(dibenzothiazepine, 12b)
Affinity DataKi:  0.320nM ΔG°:  -53.6kJ/molepH: 7.2 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50350449BDBM50350449(CHEMBL1814331)
Affinity DataIC50: 0.400nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50350428BDBM50350428(CHEMBL1814153)
Affinity DataIC50: 0.5nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 29061BDBM29061(CHEMBL201602 | pyrazolopyrimidinone-based antagoni...)
Affinity DataKi:  0.600nM ΔG°:  -53.5kJ/mole EC50:  1nMpH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 21278BDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataKi:  0.650nM ΔG°:  -53.3kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 29070BDBM29070(lactam-based compound, 12i)
Affinity DataKi:  0.700nM ΔG°:  -53.1kJ/mole EC50:  0.800nMpH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 29076BDBM29076(ether-based lactam, 19e)
Affinity DataKi:  1.40nM ΔG°:  -51.4kJ/mole EC50:  0.700nMpH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 27337BDBM27337(1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-...)
Affinity DataKi:  0.700nM ΔG°:  -53.1kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 29097BDBM29097(dibenzothiazepine, 12c)
Affinity DataKi:  0.790nM ΔG°:  -51.4kJ/molepH: 7.2 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50350448BDBM50350448(CHEMBL1814330)
Affinity DataIC50: 0.800nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 29075BDBM29075(PF-514273)
Affinity DataKi:  1nM ΔG°:  -52.2kJ/mole EC50:  0.820nMpH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 21278BDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataKi:  0.900nM ΔG°:  -52.5kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 35870BDBM35870(5,6-bis-(4-bromo-phenyl)-pyrazine-2-carboxylicacid...)
Affinity DataIC50: 1nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50350450BDBM50350450(CHEMBL1814335)
Affinity DataIC50: 1nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50350430BDBM50350430(CHEMBL1814155)
Affinity DataIC50: 1.10nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 208271BDBM208271(US9266835, 44)
Affinity DataEC50:  1.20nMpH: 7.4 T: 2°CAssay Description:Experimental Procedure CB-1 Membrane Binding: Into Greiner V bottom polypropylene plates, hCB1-CHO-K1 membranes (2 ug/well final concentration) in as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2017
Entry Details
US Patent

TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 29101BDBM29101(dibenzothiazepine, 12j)
Affinity DataKi:  1.20nM ΔG°:  -50.4kJ/molepH: 7.2 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 29073BDBM29073(ether-based lactam, 19b)
Affinity DataKi:  1.30nM ΔG°:  -51.6kJ/mole EC50:  4.80nMpH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 29074BDBM29074(ether-based lactam, 19c)
Affinity DataKi:  1.90nM ΔG°:  -50.6kJ/mole EC50:  1.5nMpH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 29102BDBM29102(dibenzothiazepine, 12k)
Affinity DataKi:  1.60nM ΔG°:  -49.7kJ/molepH: 7.2 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 21278BDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataKi:  1.80nM ΔG°:  -50.7kJ/mole EC50:  1.60nMpH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 29069BDBM29069(lactam-based compound, 12h)
Affinity DataKi:  1.70nM ΔG°:  -50.9kJ/mole EC50:  3.10nMpH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 50072775BDBM50072775(ChEMBL_75020 | 5-(1,1-Dimethyl-heptyl)-2-[(1R,2R,5...)
Affinity DataKd:  1.80nMpH: 7.4Assay Description:Briefly, ~5μg of membranes were incubated at 30 °C for 60 min with [3H]CP55940 (147.9 Ci/mmol; PerkinElmer Life Sciences) or [3H]SR141716A (43 C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCannabinoid receptor 1(Rat)
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50350436BDBM50350436(CHEMBL1814316)
Affinity DataIC50: 2nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 21278BDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataKi:  2nM ΔG°:  -49.2kJ/molepH: 7.2 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 27341BDBM27341(8-(2-chlorophenyl)-9-(4-chlorophenyl)-6-(piperidin...)
Affinity DataKi:  2.10nM ΔG°:  -50.4kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 21278BDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataKd:  2.10nMpH: 7.4Assay Description:Briefly, ~5μg of membranes were incubated at 30 °C for 60 min with [3H]CP55940 (147.9 Ci/mmol; PerkinElmer Life Sciences) or [3H]SR141716A (43 C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 27341BDBM27341(8-(2-chlorophenyl)-9-(4-chlorophenyl)-6-(piperidin...)
Affinity DataKi:  2.30nM ΔG°:  -50.1kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 29064BDBM29064(lactam-based compound, 12c)
Affinity DataKi:  2.5nM ΔG°:  -49.9kJ/mole EC50:  5.5nMpH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 29065BDBM29065(lactam-based compound, 12d)
Affinity DataKi:  2.5nM ΔG°:  -49.9kJ/mole EC50:  9.80nMpH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 27343BDBM27343(8-(2-chlorophenyl)-9-(4-chlorophenyl)-6-(4-methylp...)
Affinity DataKi:  2.80nM ΔG°:  -49.6kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 27337BDBM27337(1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-...)
Affinity DataKi:  2.80nM ΔG°:  -49.6kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 50067499BDBM50067499((6aR,10aR)-3-(1,1-dimethyl-heptyl)-9-hydroxymethyl...)
Affinity DataKi:  2.94nM ΔG°:  -49.5kJ/molepH: 7.4 T: 2°CAssay Description:The Kd of CP 55,940 in the isolated CB1 and CB2 receptor expressing membranes was previously determined to be 2.3 nM and 1.5 nM, respectively (see Pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 21278BDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataIC50: 3nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50350452BDBM50350452(CHEMBL1814338)
Affinity DataIC50: 3nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 29094BDBM29094(3-(4-chlorophenyl)-N''''-(4-chlorophenylsulfonyl)-...)
Affinity DataKi:  3nM ΔG°:  -48.2kJ/molepH: 7.2 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 29095BDBM29095(dibenzothiazepine, 12a)
Affinity DataKi:  3nM ΔG°:  -48.2kJ/molepH: 7.2 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50350444BDBM50350444(CHEMBL1814326)
Affinity DataIC50: 3nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 227552BDBM227552(US9339486, CP55,940)
Affinity DataKi:  3.40nMpH: 7.4Assay Description:Cell membrane homogenates (25 μg protein) were incubated for 120 min at 37° C. with 0.5 nM [3H]CP 55940 (the reference standard [Rinaldi-Carmona...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2017
Entry Details
US Patent

TargetCannabinoid receptor 1(Rat)
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 27338BDBM27338(9-(4-chlorophenyl)-8-(2,4-dichlorophenyl)-N-(piper...)
Affinity DataKi:  3.60nM ΔG°:  -49.0kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 35873BDBM35873(5,6-bis-(4-chloro-phenyl)-pyrazine-2-carboxylic ac...)
Affinity DataIC50: 4nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50350456BDBM50350456(CHEMBL1814332)
Affinity DataIC50: 4nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Acadia Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 208330BDBM208330(US9266835, 503)
Affinity DataEC50:  4.10nMpH: 7.4 T: 2°CAssay Description:Experimental Procedure CB-1 Membrane Binding: Into Greiner V bottom polypropylene plates, hCB1-CHO-K1 membranes (2 ug/well final concentration) in as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2017
Entry Details
US Patent

TargetCannabinoid receptor 1(Rat)
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 27340BDBM27340(9-(4-chlorophenyl)-8-(2,4-dichlorophenyl)-6-(piper...)
Affinity DataKi:  4.20nM ΔG°:  -48.6kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
Displayed 1 to 50 (of 219 total ) | Next | Last >>
Jump to: