Compile Data Set for Download or QSAR
Report error Found 922 of ph data with Target = 'Carbonic anhydrase 2'
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 11404BDBM11404(3-{[(2-methoxyethyl)(3-methoxypropyl)amino]methyl}...)
Affinity DataKi:  0.0800nM ΔG°:  -59.9kJ/molepH: 7.4 T: 2°CAssay Description:Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 11935BDBM11935(2-(3-methoxyphenyl)-1,1-dioxo-2H,3H,4H-1,7,2-thien...)
Affinity DataKd:  0.100nMpH: 7.4 T: 2°CAssay Description:The binding of test compounds to purified human erythrocyte carbonic anhydrase II was determined by a fluorescence competition assay using a Perkin-E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 11936BDBM11936((4R)-2-(3-methoxyphenyl)-4-(methylamino)-1,1-dioxo...)
Affinity DataKd:  0.100nMpH: 7.4 T: 2°CAssay Description:The binding of test compounds to purified human erythrocyte carbonic anhydrase II was determined by a fluorescence competition assay using a Perkin-E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 11399BDBM11399(Compound 17a7 | 3-{[(2-methoxyethyl)(prop-2-en-1-y...)
Affinity DataKi:  0.100nM ΔG°:  -59.4kJ/molepH: 7.4 T: 2°CAssay Description:Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 10885BDBM10885((4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-...)
Affinity DataKd:  0.130nMpH: 7.4 T: 2°CAssay Description:The binding of test compounds to purified human erythrocyte carbonic anhydrase II was determined by a fluorescence competition assay using a Perkin-E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 11938BDBM11938(2-(3-methoxyphenyl)-1,1-dioxo-2H-1,7,2-thieno[3,2-...)
Affinity DataKd:  0.130nMpH: 7.4 T: 2°CAssay Description:The binding of test compounds to purified human erythrocyte carbonic anhydrase II was determined by a fluorescence competition assay using a Perkin-E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 10885BDBM10885((4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-...)
Affinity DataKi:  0.130nM ΔG°:  -58.7kJ/molepH: 7.4 T: 2°CAssay Description:Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 11398BDBM11398(3-[N-(2-Methoxyethyl)-N-methylamino]methyl]-2-meth...)
Affinity DataKi:  0.150nM ΔG°:  -58.3kJ/molepH: 7.4 T: 2°CAssay Description:Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 11390BDBM11390(2-(3-hydroxyphenyl)-3-(morpholin-4-ylmethyl)-1,1-d...)
Affinity DataKi:  0.150nM ΔG°:  -58.3kJ/molepH: 7.4 T: 2°CAssay Description:Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 11391BDBM11391(2-(3-Methoxyphenyl)-3-[(4-morpholinyl)methyl]-2H-t...)
Affinity DataKi:  0.150nM ΔG°:  -58.3kJ/molepH: 7.4 T: 2°CAssay Description:Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 11933BDBM11933(4-hydroxy-2-(4-methoxyphenyl)-1,1-dioxo-2H,3H,4H-1...)
Affinity DataKd:  0.160nMpH: 7.4 T: 2°CAssay Description:The binding of test compounds to purified human erythrocyte carbonic anhydrase II was determined by a fluorescence competition assay using a Perkin-E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 11932BDBM11932(4-hydroxy-1,1-dioxo-2-(thiophen-2-ylmethyl)-2H,3H,...)
Affinity DataKd:  0.200nMpH: 7.4 T: 2°CAssay Description:The binding of test compounds to purified human erythrocyte carbonic anhydrase II was determined by a fluorescence competition assay using a Perkin-E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 14722BDBM14722(Sulfonamide, 8 | 1-N-[5-Sulfamoyl-1,3,4-thiadiazol...)
Affinity DataKi:  0.200nM ΔG°:  -54.4kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 11400BDBM11400(2-Ethyl-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]...)
Affinity DataKi:  0.210nM ΔG°:  -57.5kJ/molepH: 7.4 T: 2°CAssay Description:Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 11401BDBM11401(2-Ethyl-3-[[bis(2-methoxyethyl)amino]methyl]-2H-th...)
Affinity DataKi:  0.210nM ΔG°:  -57.5kJ/molepH: 7.4 T: 2°CAssay Description:Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 11403BDBM11403(2-[(2E)-4-(morpholin-4-yl)but-2-en-1-yl]-1,1-dioxo...)
Affinity DataKi:  0.240nM ΔG°:  -57.1kJ/molepH: 7.4 T: 2°CAssay Description:Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 222054BDBM222054((3aR,4S,7R,7aS)-2-(4-((E)-3-(4-bromophenyl)acryloy...)
Affinity DataKi:  0.245nM ΔG°:  -54.9kJ/mole IC50: 0.352nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 11395BDBM11395(Compound 5c | 2-[2-[4-Acetyl-(1-piperazinyl)]ethyl...)
Affinity DataKi:  0.25nM ΔG°:  -57.0kJ/molepH: 7.4 T: 2°CAssay Description:Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 222051BDBM222051((3aR,4S,7R,7aS)-2-(4-((E)-3-(4-chlorophenyl)acrylo...)
Affinity DataKi:  0.258nM ΔG°:  -54.7kJ/mole IC50: 0.373nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 11397BDBM11397(2-methyl-3-(morpholin-4-ylmethyl)-1,1-dioxo-2H-1,7...)
Affinity DataKi:  0.260nM ΔG°:  -56.9kJ/molepH: 7.4 T: 2°CAssay Description:Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 222046BDBM222046((3aR,4S,7R,7aS)-2-(4-((E)-3-(4-methoxyphenyl)acryl...)
Affinity DataKi:  0.277nM ΔG°:  -54.5kJ/mole IC50: 0.356nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 11625BDBM11625(2-N-(4-amino-3-chloro-5-fluorobenzene)-1,3,4-thiad...)
Affinity DataKi:  0.300nMpH: 7.5Assay Description:Inhibition of human carbonic anhydrase II by spectrophotometry at pH 7.5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 11625BDBM11625(2-N-(4-amino-3-chloro-5-fluorobenzene)-1,3,4-thiad...)
Affinity DataKi:  0.300nMpH: 7.5Assay Description:Inhibition of human recombinant carbonic anhydrase 2 at pH 7.5 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 222050BDBM222050((3aR,4S,7R,7aS)-2-(4-((E)-3-(o-tolyl)acryloyl)phen...)
Affinity DataKi:  0.302nM ΔG°:  -54.3kJ/mole IC50: 0.353nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 11934BDBM11934((4R)-4-(ethylamino)-2-(2-methoxyethyl)-1,1-dioxo-2...)
Affinity DataKd:  0.320nMpH: 7.4 T: 2°CAssay Description:The binding of test compounds to purified human erythrocyte carbonic anhydrase II was determined by a fluorescence competition assay using a Perkin-E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 11394BDBM11394(Compound 5b | 2-[2-(4-Morpholinyl)ethyl]-2H-thieno...)
Affinity DataKi:  0.320nM ΔG°:  -56.4kJ/molepH: 7.4 T: 2°CAssay Description:Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 222047BDBM222047((3aR,4S,7R,7aS)-2-(4-((E)-3-(3-methoxyphenyl)acryl...)
Affinity DataKi:  0.337nM ΔG°:  -54.1kJ/mole IC50: 0.435nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 11393BDBM11393(2-{2-[bis(2-methoxyethyl)amino]ethyl}-1,1-dioxo-2H...)
Affinity DataKi:  0.340nM ΔG°:  -56.2kJ/molepH: 7.4 T: 2°CAssay Description:Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 222055BDBM222055((3aR,4S,7R,7aS)-2-(4-((E)-3-(3-bromophenyl)acryloy...)
Affinity DataKi:  0.343nM ΔG°:  -54.0kJ/mole IC50: 0.382nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 10880BDBM10880(Acetazolamide, AAZ | AZA2 | CHEMBL20 | Acetazolami...)
Affinity DataKi:  0.343nM ΔG°:  -54.0kJ/mole IC50: 0.485nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 222052BDBM222052((3aR,4S,7R,7aS)-2-(4-((E)-3-(3-chlorophenyl)acrylo...)
Affinity DataKi:  0.361nM ΔG°:  -53.9kJ/mole IC50: 0.419nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 222053BDBM222053((3aR,4S,7R,7aS)-2-(4-((E)-3-(2-chlorophenyl)acrylo...)
Affinity DataKi:  0.377nM ΔG°:  -53.8kJ/mole IC50: 0.444nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 222056BDBM222056((3aR,4S,7R,7aS)-2-(4-((E)-3-(2-bromophenyl)acryloy...)
Affinity DataKi:  0.379nM ΔG°:  -53.8kJ/mole IC50: 0.415nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 222057BDBM222057((3aR,4S,7R,7aS)-2-(4-((E)-3-(furan-2-yl)acryloyl)p...)
Affinity DataKi:  0.390nM ΔG°:  -53.7kJ/mole IC50: 0.555nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 222048BDBM222048((3aR,4S,7R,7aS)-2-(4-((E)-3-(p-tolyl)acryloyl)phen...)
Affinity DataKi:  0.400nM ΔG°:  -53.6kJ/mole IC50: 0.406nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 222049BDBM222049((3aR,4S,7R,7aS)-2-(4-((E)-3-(m-tolyl)acryloyl)phen...)
Affinity DataKi:  0.404nM ΔG°:  -53.6kJ/mole IC50: 0.449nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 222058BDBM222058((3aR,4S,7R,7aS)-2-(4-((E)-3-(thiophen-2-yl)acryloy...)
Affinity DataKi:  0.412nM ΔG°:  -53.6kJ/mole IC50: 0.488nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 11929BDBM11929(2-N-[(4-methylphenyl)methyl]thiophene-2,5-disulfon...)
Affinity DataKd:  0.460nMpH: 7.4 T: 2°CAssay Description:The binding of test compounds to purified human erythrocyte carbonic anhydrase II was determined by a fluorescence competition assay using a Perkin-E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 222059BDBM222059((3aR,4S,7R,7aS)-2-(4-((E)-3-(pyridin-4-yl)acryloyl...)
Affinity DataKi:  0.490nM ΔG°:  -53.1kJ/mole IC50: 0.551nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 11930BDBM11930(2-N-[(4-methoxyphenyl)methyl]thiophene-2,5-disulfo...)
Affinity DataKd:  0.490nMpH: 7.4 T: 2°CAssay Description:The binding of test compounds to purified human erythrocyte carbonic anhydrase II was determined by a fluorescence competition assay using a Perkin-E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 11396BDBM11396(2-[2-(Propylamino)ethyl]-2H-thieno[3,2-e]-1,2-thia...)
Affinity DataKi:  0.520nM ΔG°:  -55.1kJ/molepH: 7.4 T: 2°CAssay Description:Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 13073BDBM13073(2000-07790 | 3-nitro-4-(2-oxopyrrolidin-1-yl)benze...)
Affinity DataIC50: 0.620nMpH: 7.4 T: 2°CAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2007
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 33280BDBM33280(CHEMBL153094 | aliphatic sulfamate, 2)
Affinity DataKi:  0.700nM ΔG°:  -51.9kJ/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2009
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 10882BDBM10882(6-ethoxy-1,3-benzothiazole-2-sulfonamide | Ethoxzo...)
Affinity DataKd:  0.710nMpH: 7.0Assay Description:The thermal shift assay (TSA) measurements were performed in a Corbett Rotor-Gene 6000 (QIAGEN Rotor-Gene Q, Sydney, Australia) instrument using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 13077BDBM13077(5-(thiophene-2-sulfonyl)thiophene-2-sulfonamide | ...)
Affinity DataIC50: 0.810nMpH: 7.4 T: 2°CAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2007
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 11394BDBM11394(Compound 5b | 2-[2-(4-Morpholinyl)ethyl]-2H-thieno...)
Affinity DataIC50: 0.820nMpH: 7.2 T: 2°CAssay Description:The assay measured the rate of CO2 hydration by determining the addition rate of a NaOH solution using a Radiometer VIT 90 titration system. The enzy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 11931BDBM11931(2-N-(thiophen-2-ylmethyl)thiophene-2,5-disulfonami...)
Affinity DataKd:  0.830nMpH: 7.4 T: 2°CAssay Description:The binding of test compounds to purified human erythrocyte carbonic anhydrase II was determined by a fluorescence competition assay using a Perkin-E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 13068BDBM13068(5-(thiophen-2-ylsulfanyl)thiophene-2-sulfonamide |...)
Affinity DataIC50: 0.890nMpH: 7.4 T: 2°CAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2007
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 11393BDBM11393(2-{2-[bis(2-methoxyethyl)amino]ethyl}-1,1-dioxo-2H...)
Affinity DataIC50: 0.910nMpH: 7.2 T: 2°CAssay Description:The assay measured the rate of CO2 hydration by determining the addition rate of a NaOH solution using a Radiometer VIT 90 titration system. The enzy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Alcon Research

LigandChemical structure of BindingDB Monomer ID 11395BDBM11395(Compound 5c | 2-[2-[4-Acetyl-(1-piperazinyl)]ethyl...)
Affinity DataIC50: 0.960nMpH: 7.2 T: 2°CAssay Description:The assay measured the rate of CO2 hydration by determining the addition rate of a NaOH solution using a Radiometer VIT 90 titration system. The enzy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
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