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Found 922 of ph data with Target = 'Carbonic anhydrase 2'
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM11404(2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-di...)
Affinity DataKi:  0.0800nM ΔG°:  -59.9kJ/molepH: 7.4 T: 2°CAssay Description:Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM11399(2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-di...)
Affinity DataKi:  0.100nM ΔG°:  -59.4kJ/molepH: 7.4 T: 2°CAssay Description:Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM10885((4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-...)
Affinity DataKi:  0.130nM ΔG°:  -58.7kJ/molepH: 7.4 T: 2°CAssay Description:Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM11398(2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-di...)
Affinity DataKi:  0.150nM ΔG°:  -58.3kJ/molepH: 7.4 T: 2°CAssay Description:Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM11391(2-(3-Methoxyphenyl)-3-[(4-morpholinyl)methyl]-2H-t...)
Affinity DataKi:  0.150nM ΔG°:  -58.3kJ/molepH: 7.4 T: 2°CAssay Description:Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM11390(2-(3-Hydroxyphenyl)-3-(4-morpholinylmethyl)-2H-thi...)
Affinity DataKi:  0.150nM ΔG°:  -58.3kJ/molepH: 7.4 T: 2°CAssay Description:Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM14722(1-N-[5-Sulfamoyl-1,3,4-thiadiazol-2-yl-(aminosulfo...)
Affinity DataKi:  0.200nM ΔG°:  -54.4kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM11401(2-Ethyl-3-[[bis(2-methoxyethyl)amino]methyl]-2H-th...)
Affinity DataKi:  0.210nM ΔG°:  -57.5kJ/molepH: 7.4 T: 2°CAssay Description:Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM11400(2-Ethyl-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]...)
Affinity DataKi:  0.210nM ΔG°:  -57.5kJ/molepH: 7.4 T: 2°CAssay Description:Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM11403(2-[(2E)-4-(morpholin-4-yl)but-2-en-1-yl]-1,1-dioxo...)
Affinity DataKi:  0.240nM ΔG°:  -57.1kJ/molepH: 7.4 T: 2°CAssay Description:Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM222054((3aR,4S,7R,7aS)-2-(4-((E)-3-(4-bromophenyl)acryloy...)
Affinity DataKi:  0.245nM ΔG°:  -54.9kJ/mole IC50:  0.352nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM11395(2-[2-(4-acetylpiperazin-1-yl)ethyl]-1,1-dioxo-2H-1...)
Affinity DataKi:  0.25nM ΔG°:  -57.0kJ/molepH: 7.4 T: 2°CAssay Description:Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM222051((3aR,4S,7R,7aS)-2-(4-((E)-3-(4-chlorophenyl)acrylo...)
Affinity DataKi:  0.258nM ΔG°:  -54.7kJ/mole IC50:  0.373nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM11397(2-Methyl-3-(4-morpholinylmethyl)-2H-thieno[3,2-e]-...)
Affinity DataKi:  0.260nM ΔG°:  -56.9kJ/molepH: 7.4 T: 2°CAssay Description:Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM222046((3aR,4S,7R,7aS)-2-(4-((E)-3-(4-methoxyphenyl)acryl...)
Affinity DataKi:  0.277nM ΔG°:  -54.5kJ/mole IC50:  0.356nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM11625(2-N-(4-amino-3-chloro-5-fluorobenzene)-1,3,4-thiad...)
Affinity DataKi:  0.300nMpH: 7.5Assay Description:Inhibition of human carbonic anhydrase II by spectrophotometry at pH 7.5More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM11625(2-N-(4-amino-3-chloro-5-fluorobenzene)-1,3,4-thiad...)
Affinity DataKi:  0.300nMpH: 7.5Assay Description:Inhibition of human recombinant carbonic anhydrase 2 at pH 7.5 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM222050((3aR,4S,7R,7aS)-2-(4-((E)-3-(o-tolyl)acryloyl)phen...)
Affinity DataKi:  0.302nM ΔG°:  -54.3kJ/mole IC50:  0.353nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM11394(2-[2-(4-Morpholinyl)ethyl]-2H-thieno[3,2-e]-1,2-th...)
Affinity DataKi:  0.320nM ΔG°:  -56.4kJ/molepH: 7.4 T: 2°CAssay Description:Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM222047((3aR,4S,7R,7aS)-2-(4-((E)-3-(3-methoxyphenyl)acryl...)
Affinity DataKi:  0.337nM ΔG°:  -54.1kJ/mole IC50:  0.435nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM11393(2-[2-[Bis(2-methoxyethyl)amino]ethyl]-2H-thieno[3,...)
Affinity DataKi:  0.340nM ΔG°:  -56.2kJ/molepH: 7.4 T: 2°CAssay Description:Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM222055((3aR,4S,7R,7aS)-2-(4-((E)-3-(3-bromophenyl)acryloy...)
Affinity DataKi:  0.343nM ΔG°:  -54.0kJ/mole IC50:  0.382nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Affinity DataKi:  0.343nM ΔG°:  -54.0kJ/mole IC50:  0.485nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM222052((3aR,4S,7R,7aS)-2-(4-((E)-3-(3-chlorophenyl)acrylo...)
Affinity DataKi:  0.361nM ΔG°:  -53.9kJ/mole IC50:  0.419nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM222053((3aR,4S,7R,7aS)-2-(4-((E)-3-(2-chlorophenyl)acrylo...)
Affinity DataKi:  0.377nM ΔG°:  -53.8kJ/mole IC50:  0.444nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM222056((3aR,4S,7R,7aS)-2-(4-((E)-3-(2-bromophenyl)acryloy...)
Affinity DataKi:  0.379nM ΔG°:  -53.8kJ/mole IC50:  0.415nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM222057((3aR,4S,7R,7aS)-2-(4-((E)-3-(furan-2-yl)acryloyl)p...)
Affinity DataKi:  0.390nM ΔG°:  -53.7kJ/mole IC50:  0.555nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM222048((3aR,4S,7R,7aS)-2-(4-((E)-3-(p-tolyl)acryloyl)phen...)
Affinity DataKi:  0.400nM ΔG°:  -53.6kJ/mole IC50:  0.406nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM222049((3aR,4S,7R,7aS)-2-(4-((E)-3-(m-tolyl)acryloyl)phen...)
Affinity DataKi:  0.404nM ΔG°:  -53.6kJ/mole IC50:  0.449nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM222058((3aR,4S,7R,7aS)-2-(4-((E)-3-(thiophen-2-yl)acryloy...)
Affinity DataKi:  0.412nM ΔG°:  -53.6kJ/mole IC50:  0.488nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM222059((3aR,4S,7R,7aS)-2-(4-((E)-3-(pyridin-4-yl)acryloyl...)
Affinity DataKi:  0.490nM ΔG°:  -53.1kJ/mole IC50:  0.551nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM11396(1,1-dioxo-2-[2-(propylamino)ethyl]-2H-1,7,2-thieno...)
Affinity DataKi:  0.520nM ΔG°:  -55.1kJ/molepH: 7.4 T: 2°CAssay Description:Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM33280(CHEMBL153094 | aliphatic sulfamate, 2)
Affinity DataKi:  0.700nM ΔG°:  -51.9kJ/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM50098102(CHEMBL23350 | Sulfamic acid 4-chloro-phenyl ester)
Affinity DataKi:  1.10nMpH: 7.5Assay Description:Inhibition of human carbonic anhydrase II by spectrophotometry at pH 7.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM11636(CHEMBL309431 | N-[2-(diethylamino)ethyl]-4-[(5-sul...)
Affinity DataKi:  1.40nM ΔG°:  -50.0kJ/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM11634(2,3,4,5,6-pentafluoro-N-(3-methyl-5-sulfamoyl-2,3-...)
Affinity DataKi:  1.5nM ΔG°:  -49.9kJ/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM10870(2-N-(4-aminobenzene)-1,3,4-thiadiazole-2,5-disulfo...)
Affinity DataKi:  2nMpH: 7.5Assay Description:Inhibition of human carbonic anhydrase II by spectrophotometry at pH 7.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM10870(2-N-(4-aminobenzene)-1,3,4-thiadiazole-2,5-disulfo...)
Affinity DataKi:  2nMpH: 7.5Assay Description:Inhibition of human recombinant carbonic anhydrase 2 at pH 7.5 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM33279(CHEMBL24261 | aliphatic sulfamate, 1)
Affinity DataKi:  2.60nM ΔG°:  -48.7kJ/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM150251(US8980932, 6c (DH310))
Affinity DataKi:  2.90nMpH: 7.5Assay Description:The inhibition constants (K) the compounds for four CA isozymes, CA I, II, IX and XII were determined. An Applied Photophysics (Oxford, UK) stopped-f...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM10885((4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-...)
Affinity DataKi:  3nMpH: 7.5Assay Description:Inhibition of human recombinant carbonic anhydrase 2 at pH 7.5 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM10885((4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-...)
Affinity DataKi:  3nMpH: 7.5Assay Description:Inhibition of human carbonic anhydrase 2 after 15 mins by CO2 hydrase assay at pH 7.5More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM13056((4S)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-...)
Affinity DataKi:  3nM ΔG°:  -48.2kJ/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM82123(Brinzolamide, BRZ)
Affinity DataKi:  3nM ΔG°:  -47.8kJ/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM10885((4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-...)
Affinity DataKi:  3nMpH: 7.5Assay Description:Inhibition of human carbonic anhydrase II by spectrophotometry at pH 7.5More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM150254(US8980932, 4d (DH302))
Affinity DataKi:  3.80nMpH: 7.5Assay Description:The inhibition constants (K) the compounds for four CA isozymes, CA I, II, IX and XII were determined. An Applied Photophysics (Oxford, UK) stopped-f...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM150256(US8980932, 4c (DH305))
Affinity DataKi:  4.80nMpH: 7.5Assay Description:The inhibition constants (K) the compounds for four CA isozymes, CA I, II, IX and XII were determined. An Applied Photophysics (Oxford, UK) stopped-f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM11635(4-sulfamoyl-N-[2-(4-sulfamoylphenyl)ethyl]benzamid...)
Affinity DataKi:  5nMpH: 7.5Assay Description:Inhibition of human carbonic anhydrase II by spectrophotometry at pH 7.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM11635(4-sulfamoyl-N-[2-(4-sulfamoylphenyl)ethyl]benzamid...)
Affinity DataKi:  5nMpH: 7.5Assay Description:Inhibition of human recombinant carbonic anhydrase 2 at pH 7.5 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Alcon Research

LigandPNGBDBM10887(Sulfamate 7 | Topiramate (TPM) | US11535599, Examp...)
Affinity DataKi:  5nM ΔG°:  -46.9kJ/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
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