Compile Data Set for Download or QSAR
Report error Found 19 of ph data with Target = 'Caspase-8'
TargetCaspase-8(Human)
Sunesis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 225BDBM225(Thiophene Scaffold 66a | (S)-5-5-(1-Carboxymethyl-...)
Affinity DataKi:  50nM ΔG°:  -41.7kJ/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-8(Human)
Sunesis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 220BDBM220(5-{[(4-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl...)
Affinity DataKi:  150nM ΔG°:  -38.9kJ/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-8(Human)
Sunesis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 226BDBM226(Thiophene Scaffold 66b | (S)-5-({5-[1-Carboxymethy...)
Affinity DataKi:  330nM ΔG°:  -37.0kJ/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-8(Human)
Sunesis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 227BDBM227(Heterocyclic deriv. 69b | (S)-5-({5-[1-Carboxymeth...)
Affinity DataKi:  710nM ΔG°:  -35.1kJ/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-8(Human)
Sunesis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 222BDBM222((S)-5-({5-[1-Carboxymethyl-3-(2-chloro-benzylsulfa...)
Affinity DataKi:  810nM ΔG°:  -34.8kJ/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-8(Human)
Sunesis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 221BDBM221(Pyridine Scaffold 4 | 5-{[(5-{[(2S)-1-carboxy-3-ox...)
Affinity DataKi:  880nM ΔG°:  -34.6kJ/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-8(Human)
Sunesis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 219BDBM219(5-({[(5-{[(2S)-1-carboxy-4-{[(2-chlorophenyl)methy...)
Affinity DataKi:  4.00E+3nM ΔG°:  -30.8kJ/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-8(Human)
Sunesis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 224BDBM224((S)-5-({5-[1-Carboxymethyl-3-(2-chloro-benzylsulfa...)
Affinity DataKi:  1.90E+4nM ΔG°:  -26.9kJ/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-8(Human)
Sunesis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 223BDBM223(5-{[(5-{[(2S)-1-carboxy-4-{[(2-chlorophenyl)methyl...)
Affinity DataKi:  2.80E+4nM ΔG°:  -26.0kJ/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-8(Human)
Sunesis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 29574BDBM29574(isatin Michael acceptor (IMA) analogue, 11c)
Affinity DataIC50: 5.00E+4nMpH: 7.4 T: 2°CAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCaspase-8(Human)
Sunesis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 29575BDBM29575(isatin Michael acceptor (IMA) analogue, 12a)
Affinity DataIC50: 5.00E+4nMpH: 7.4 T: 2°CAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCaspase-8(Human)
Sunesis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 29576BDBM29576(isatin Michael acceptor (IMA) analogue, 12b)
Affinity DataIC50: 5.00E+4nMpH: 7.4 T: 2°CAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCaspase-8(Human)
Sunesis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 29577BDBM29577(isatin Michael acceptor (IMA) analogue, 12c)
Affinity DataIC50: 5.00E+4nMpH: 7.4 T: 2°CAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCaspase-8(Human)
Sunesis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 29578BDBM29578(isatin Michael acceptor (IMA) analogue, 13a)
Affinity DataIC50: 5.00E+4nMpH: 7.4 T: 2°CAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCaspase-8(Human)
Sunesis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 29569BDBM29569(isatin sulfonamide, 6 | acs.jmedchem.1c00409_ST.54...)
Affinity DataIC50: 5.00E+4nMpH: 7.4 T: 2°CAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCaspase-8(Human)
Sunesis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 29570BDBM29570(isatin sulfonamide, 9c)
Affinity DataIC50: 5.00E+4nMpH: 7.4 T: 2°CAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCaspase-8(Human)
Sunesis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 29571BDBM29571(isatin sulfonamide, 10a)
Affinity DataIC50: 5.00E+4nMpH: 7.4 T: 2°CAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCaspase-8(Human)
Sunesis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 29572BDBM29572(isatin Michael acceptor (IMA) analogue, 11a)
Affinity DataIC50: 5.00E+4nMpH: 7.4 T: 2°CAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCaspase-8(Human)
Sunesis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 29573BDBM29573(isatin Michael acceptor (IMA) analogue, 11b)
Affinity DataIC50: 5.00E+4nMpH: 7.4 T: 2°CAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed