Compile Data Set for Download or QSAR
Report error Found 190 of ph data with Target = 'Coagulation factor VII'
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 14714BDBM14714((2R)-N-[(3-aminobenzene)sulfonyl]-2-[(4-carbamimid...)
Affinity DataKi:  0.350nM ΔG°:  -53.4kJ/molepH: 7.8 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2007
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 13554BDBM13554(phenylglycine amide compound 10 | (2S)-2-{2-[2-(be...)
Affinity DataKi:  2nM ΔG°:  -49.2kJ/molepH: 7.8 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2007
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 13554BDBM13554(phenylglycine amide compound 10 | (2S)-2-{2-[2-(be...)
Affinity DataKi:  2nM ΔG°:  -49.2kJ/molepH: 7.8 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2007
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 13552BDBM13552((2S)-2-[(2R)-2-[4-(benzyloxy)-3-methoxyphenyl]-2-[...)
Affinity DataKi:  4nM ΔG°:  -47.5kJ/molepH: 7.8 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2007
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 13552BDBM13552((2S)-2-[(2R)-2-[4-(benzyloxy)-3-methoxyphenyl]-2-[...)
Affinity DataKi:  4nM ΔG°:  -47.5kJ/molepH: 7.8 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2007
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 13778BDBM13778(2-[3-(5-carbamimidoyl-1H-indol-2-yl)-4-hydroxy-5-(...)
Affinity DataKi:  4nM ΔG°:  -47.5kJ/molepH: 7.4 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2007
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 14898BDBM14898(CHEMBL377082 | 2-[3-(5-carbamimidoyl-1H-1,3-benzod...)
Affinity DataKi:  4nM ΔG°:  -47.5kJ/molepH: 7.4 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 14899BDBM14899(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-5-(...)
Affinity DataKi:  5.40nM ΔG°:  -46.7kJ/molepH: 7.4 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 14900BDBM14900(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-4-h...)
Affinity DataKi:  6nM ΔG°:  -46.5kJ/molepH: 7.4 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 13555BDBM13555((2S)-2-{2-[4-(benzyloxy)-5-methoxy-2-(2-phenylacet...)
Affinity DataKi:  7nM ΔG°:  -46.1kJ/molepH: 7.8 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2007
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 13555BDBM13555((2S)-2-{2-[4-(benzyloxy)-5-methoxy-2-(2-phenylacet...)
Affinity DataKi:  7nM ΔG°:  -46.1kJ/molepH: 7.8 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2007
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 31488BDBM31488(substituted biphenyl derivative, 36ab)
Affinity DataIC50: 9nMpH: 7.2 T: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2009
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 14904BDBM14904(2-[3-(3-bromo-5-chloro-2-hydroxyphenyl)-5-(5-carba...)
Affinity DataKi:  9nM ΔG°:  -45.5kJ/molepH: 7.4 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 31462BDBM31462(substituted biphenyl derivative, 36b)
Affinity DataIC50: 9nMpH: 7.2 T: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2009
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 31468BDBM31468(substituted biphenyl derivative, 36h)
Affinity DataIC50: 9nMpH: 7.2 T: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2009
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 31486BDBM31486(substituted biphenyl derivative, 36z)
Affinity DataIC50: 10nMpH: 7.2 T: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2009
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 31487BDBM31487(substituted biphenyl derivative, 36aa)
Affinity DataIC50: 10nMpH: 7.2 T: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2009
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 14901BDBM14901(2-[3-(5-amino-2-hydroxyphenyl)-5-(5-carbamimidoyl-...)
Affinity DataKi:  10nM ΔG°:  -45.2kJ/molepH: 7.4 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 13592BDBM13592(2-{2-[(4-carbamimidoylphenyl)carbamoyl]-6-methoxyp...)
Affinity DataKi:  10nM ΔG°:  -45.2kJ/molepH: 7.8 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2007
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 31470BDBM31470(substituted biphenyl derivative, 36j)
Affinity DataIC50: 11nMpH: 7.2 T: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2009
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 14902BDBM14902(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-5-(...)
Affinity DataKi:  12nM ΔG°:  -44.8kJ/molepH: 7.4 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 31474BDBM31474(substituted biphenyl derivative, 36n)
Affinity DataIC50: 12nMpH: 7.2 T: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2009
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 14903BDBM14903(CHEMBL444622 | 2-[3-(5-carbamimidoyl-1H-1,3-benzod...)
Affinity DataKi:  13nM ΔG°:  -44.6kJ/molepH: 7.4 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 14863BDBM14863(({3-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-2...)
Affinity DataKi:  13nM ΔG°:  -44.6kJ/molepH: 7.4 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 31467BDBM31467(substituted biphenyl derivative, 36g)
Affinity DataIC50: 13nMpH: 7.2 T: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2009
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 14905BDBM14905(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-5-(...)
Affinity DataKi:  14nM ΔG°:  -44.4kJ/molepH: 7.4 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 13776BDBM13776(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-4-h...)
Affinity DataKi:  15nM ΔG°:  -44.2kJ/molepH: 7.4 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2007
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 13786BDBM13786(2-(3-{5-amino-1H-pyrrolo[3,2-b]pyridin-2-yl}-4-hyd...)
Affinity DataKi:  20nM ΔG°:  -43.5kJ/molepH: 7.4 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2007
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 14907BDBM14907(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-4-h...)
Affinity DataKi:  21nM ΔG°:  -43.4kJ/molepH: 7.4 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 31483BDBM31483(substituted biphenyl derivative, 36w)
Affinity DataIC50: 21nMpH: 7.2 T: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2009
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 14908BDBM14908(CHEMBL382776 | 2-[3-(5-carbamimidoyl-1H-1,3-benzod...)
Affinity DataKi:  22nM ΔG°:  -43.3kJ/molepH: 7.4 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 14909BDBM14909(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-4-h...)
Affinity DataKi:  22nM ΔG°:  -43.3kJ/molepH: 7.4 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 14906BDBM14906(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-5-(...)
Affinity DataKi:  25nM ΔG°:  -43.0kJ/molepH: 7.4 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 31466BDBM31466(substituted biphenyl derivative, 36f)
Affinity DataIC50: 25nMpH: 7.2 T: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2009
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 14910BDBM14910(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-5-(...)
Affinity DataKi:  27nM ΔG°:  -42.8kJ/molepH: 7.4 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 13557BDBM13557(2-[4-(benzyloxy)-3-ethoxyphenyl]-2-[(4-carbamimido...)
Affinity DataKi:  28nM ΔG°:  -42.7kJ/molepH: 7.8 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2007
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 31475BDBM31475(substituted biphenyl derivative, 36o)
Affinity DataIC50: 29nMpH: 7.2 T: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2009
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 14911BDBM14911(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-5-(...)
Affinity DataKi:  29nM ΔG°:  -42.6kJ/molepH: 7.4 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 31461BDBM31461(substituted biphenyl derivative, 24)
Affinity DataIC50: 30nMpH: 7.2 T: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2009
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 14912BDBM14912(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-5-(...)
Affinity DataKi:  33nM ΔG°:  -42.3kJ/molepH: 7.4 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 14872BDBM14872(1-(2,6-difluorophenyl)-3-{[3-(2-hydroxy-3-{1H-pyrr...)
Affinity DataKi:  33nM ΔG°:  -42.3kJ/molepH: 7.4 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 31469BDBM31469(substituted biphenyl derivative, 36i)
Affinity DataIC50: 34nMpH: 7.2 T: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2009
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 13591BDBM13591((R)-(4-Carbamimidoyl-phenylamino)-{3-ethoxy-2-fluo...)
Affinity DataKi:  35nM ΔG°:  -42.1kJ/molepH: 7.8 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2007
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 14913BDBM14913(2-[3-(3-aminophenyl)-5-(5-carbamimidoyl-1H-1,3-ben...)
Affinity DataKi:  36nM ΔG°:  -42.1kJ/molepH: 7.4 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 13562BDBM13562(2-[(4-carbamimidoylphenyl)amino]-2-[3-ethynyl-5-(o...)
Affinity DataKi:  38nM ΔG°:  -41.9kJ/molepH: 7.8 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2007
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 13576BDBM13576(N-benzyl-2-[(4-carbamimidoylphenyl)amino]-2-(3,4-d...)
Affinity DataKi:  40nM ΔG°:  -41.8kJ/molepH: 7.8 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2007
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 189446BDBM189446(US9174974, Example 32)
Affinity DataKi:  41nMpH: 7.4Assay Description:Tissue kallikrein-1 (37° C) activity was determined in reactions containing 0.05 nM enzyme and 90 μM substrate (H-D-Val-Leu-Arg-AFC) in buffer (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 31464BDBM31464(substituted biphenyl derivative, 36d)
Affinity DataIC50: 42nMpH: 7.2 T: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2009
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 31471BDBM31471(substituted biphenyl derivative, 36k)
Affinity DataIC50: 45nMpH: 7.2 T: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2009
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 14877BDBM14877(3-{[3-(2-hydroxy-3-{1H-pyrrolo[3,2-c]pyridin-2-yl}...)
Affinity DataKi:  47nM ΔG°:  -41.4kJ/molepH: 7.4 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
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