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Report error Found 201 of ph data with Target = 'Coagulation factor XII'
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22741BDBM22741(1-(3,4-dimethylphenyl)-2-phenylethane-1,2-dione | ...)
Affinity DataKi:  4.10nM ΔG°:  -47.9kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22850BDBM22850(1,2-dicyclohexylethane-1,2-dione | 1,2-Dione-Based...)
Affinity DataKi:  5nM ΔG°:  -47.4kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22759BDBM22759(JMC505727 Compound 18 | 1-[4-(2-oxo-2-phenylacetyl...)
Affinity DataKi:  5.60nM ΔG°:  -47.1kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22859BDBM22859(1,2-dihydroaceanthrylene-1,2-dione | 1,2-Dione-Bas...)
Affinity DataKi:  7.70nM ΔG°:  -46.3kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22748BDBM22748(1-(4-methyl-3-nitrophenyl)-2-phenylethane-1,2-dion...)
Affinity DataKi:  7.90nM ΔG°:  -46.2kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22745BDBM22745(1-(2-chlorophenyl)-2-(3,4-dimethoxyphenyl)ethane-1...)
Affinity DataKi:  8.90nM ΔG°:  -46.0kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22742BDBM22742(1-(4-methoxyphenyl)-2-phenylethane-1,2-dione | Ben...)
Affinity DataKi:  10.3nM ΔG°:  -45.6kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22722BDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataKi:  14.7nM ΔG°:  -44.7kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22722BDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataKi:  14.7nM ΔG°:  -44.7kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22737BDBM22737(1-(4-chlorophenyl)-2-phenylethane-1,2-dione | Benz...)
Affinity DataKi:  18.2nM ΔG°:  -44.2kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22746BDBM22746(1-[4-(bromomethyl)phenyl]-2-phenylethane-1,2-dione...)
Affinity DataKi:  21.3nM ΔG°:  -43.8kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22738BDBM22738(1-(4-chlorophenyl)-2-(4-methylphenyl)ethane-1,2-di...)
Affinity DataKi:  22.8nM ΔG°:  -43.6kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22734BDBM22734(CHEMBL193229 | 1,2-bis(3,5-difluorophenyl)ethane-1...)
Affinity DataKi:  23.4nM ΔG°:  -43.6kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 218840BDBM218840(TATA-FXII618 (14))
Affinity DataKi:  25nMpH: 7.4Assay Description:The inhibition of plasma kallikrein and coagulation factor FXII was assessed by incubating the proteases with bicyclic peptide (twofold dilutions) an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2017
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22749BDBM22749(1-(4-nitrophenyl)-2-phenylethane-1,2-dione | Benzi...)
Affinity DataKi:  30.6nM ΔG°:  -42.9kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22795BDBM22795(1-[(4-chlorophenyl)methyl]-2,3-dihydro-1H-indole-2...)
Affinity DataKi:  32nM ΔG°:  -42.8kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22739BDBM22739(1-(4-methylphenyl)-2-phenylethane-1,2-dione | Benz...)
Affinity DataKi:  33.3nM ΔG°:  -42.7kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22804BDBM22804(1-{[(2-bromophenyl)amino]methyl}-2,3-dihydro-1H-in...)
Affinity DataKi:  47nM ΔG°:  -41.8kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22857BDBM22857(cid_6763 | 9,10-dihydrophenanthrene-9,10-dione | P...)
Affinity DataKi:  52nM ΔG°:  -41.6kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22740BDBM22740(1,2-bis(4-methylphenyl)ethane-1,2-dione | Benzil-b...)
Affinity DataKi:  60.4nM ΔG°:  -41.2kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22796BDBM22796(cid_1901244 | 1-[(3,4-dichlorophenyl)methyl]-2,3-d...)
Affinity DataKi:  67nM ΔG°:  -40.9kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22743BDBM22743(JMC505727 Compound 2 | 1,2-bis(4-methoxyphenyl)eth...)
Affinity DataKi:  70.2nM ΔG°:  -40.8kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22743BDBM22743(JMC505727 Compound 2 | 1,2-bis(4-methoxyphenyl)eth...)
Affinity DataKi:  70.2nM ΔG°:  -40.8kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22736BDBM22736(4-(2-oxo-2-phenylacetyl)benzoic acid | Benzil-base...)
Affinity DataKi:  71.5nM ΔG°:  -40.8kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 33481BDBM33481(cid_2314281 | MLS000564054 | SMR000151640 | methyl...)
Affinity DataIC50: 92.4nMpH: 7.4 T: 2°CAssay Description:HTS was performed on a total of 33,068 compounds of the MLSCN library, 23,017 of which were not in the mixture HTS plates used previously. These comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2009
Entry Details
PCBioAssay
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22731BDBM22731(1,2-bis(4-chlorophenyl)ethane-1,2-dione | Benzil-b...)
Affinity DataKi:  106nM ΔG°:  -39.8kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22858BDBM22858(2-nitro-9,10-dihydrophenanthrene-9,10-dione | NSC2...)
Affinity DataKi:  107nM ΔG°:  -39.8kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22802BDBM22802(1-[(naphthalen-2-ylamino)methyl]-2,3-dihydro-1H-in...)
Affinity DataKi:  110nM ΔG°:  -39.7kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22744BDBM22744(1,2-bis(3-methoxyphenyl)ethane-1,2-dione | Benzil-...)
Affinity DataKi:  139nM ΔG°:  -39.1kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22730BDBM22730(CHEMBL192410 | 1,2-bis(4-fluorophenyl)ethane-1,2-d...)
Affinity DataKi:  167nM ΔG°:  -38.7kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22805BDBM22805(1-{[(4-bromophenyl)amino]methyl}-2,3-dihydro-1H-in...)
Affinity DataKi:  170nM ΔG°:  -38.6kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22853BDBM22853(1,2-dihydroacenaphthylenedione | 1,2-Dione-Based C...)
Affinity DataKi:  170nM ΔG°:  -38.6kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22803BDBM22803(1-{[(4-chlorophenyl)amino]methyl}-2,3-dihydro-1H-i...)
Affinity DataKi:  200nM ΔG°:  -38.2kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22750BDBM22750(1-(2,4-dinitrophenyl)-2-phenylethane-1,2-dione | B...)
Affinity DataKi:  209nM ΔG°:  -38.1kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 32813BDBM32813(2-(2-chlorophenyl)-4-thieno[3,2-d][1,3]oxazinone |...)
Affinity DataIC50: 241nMpH: 7.4 T: 2°CAssay Description:HTS was performed on a total of 33,068 compounds of the MLSCN library, 23,017 of which were not in the mixture HTS plates used previously. These comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2009
Entry Details
PCBioAssay
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22735BDBM22735(1,2-bis(3,4,5-trifluorophenyl)ethane-1,2-dione | C...)
Affinity DataKi:  259nM ΔG°:  -37.6kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 218838BDBM218838(TATB-FXII618 (15) | TATB-PK15 (11))
Affinity DataKi:  340nMpH: 7.4Assay Description:The inhibition of plasma kallikrein and coagulation factor FXII was assessed by incubating the proteases with bicyclic peptide (twofold dilutions) an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2017
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22732BDBM22732(1,2-bis(2-chlorophenyl)ethane-1,2-dione | Benzil-b...)
Affinity DataKi:  353nM ΔG°:  -36.8kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 32824BDBM32824(SMR000148302 | cid_936917 | (3-Amino-[1,2,4]triazo...)
Affinity DataIC50: 376nMpH: 7.4 T: 2°CAssay Description:HTS was performed on a total of 33,068 compounds of the MLSCN library, 23,017 of which were not in the mixture HTS plates used previously. These comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2009
Entry Details
PCBioAssay
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22751BDBM22751(1,2-bis(3-nitrophenyl)ethane-1,2-dione | Benzil-ba...)
Affinity DataKi:  397nM ΔG°:  -36.5kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22799BDBM22799(1-{[(4-ethylphenyl)amino]methyl}-2,3-dihydro-1H-in...)
Affinity DataKi:  410nM ΔG°:  -36.5kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22848BDBM22848(1,2-bis(4-nitrophenyl)ethane-1,2-dione | 1,2-Dione...)
Affinity DataKi:  470nM ΔG°:  -36.1kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22800BDBM22800(1-{[(4-tert-butylphenyl)amino]methyl}-2,3-dihydro-...)
Affinity DataKi:  610nM ΔG°:  -35.5kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22854BDBM22854(5,6-dinitro-1,2-dihydroacenaphthylenedione | 1,2-D...)
Affinity DataKi:  620nM ΔG°:  -35.4kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 33448BDBM33448(MLS000527906 | [5-amino-3-(furan-2-yl)-1,2,4-triaz...)
Affinity DataIC50: 643nMpH: 7.4 T: 2°CAssay Description:HTS was performed on a total of 33,068 compounds of the MLSCN library, 23,017 of which were not in the mixture HTS plates used previously. These comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2009
Entry Details
PCBioAssay
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22786BDBM22786(1-(2-iodoethyl)-2,3-dihydro-1H-indole-2,3-dione | ...)
Affinity DataKi:  740nM ΔG°:  -35.0kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 32669BDBM32669((3,4-dimethoxyphenyl)-[3-(2-furanyl)-5-(methylthio...)
Affinity DataIC50: 769nMpH: 7.4 T: 2°CAssay Description:HTS was performed on a total of 33,068 compounds of the MLSCN library, 23,017 of which were not in the mixture HTS plates used previously. These comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2009
Entry Details
PCBioAssay
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 32709BDBM32709(1-(4-methylbenzoyl)-3-(3-pyridinyl)-1H-1,2,4-triaz...)
Affinity DataIC50: 796nMpH: 7.4 T: 2°CAssay Description:HTS was performed on a total of 33,068 compounds of the MLSCN library, 23,017 of which were not in the mixture HTS plates used previously. These comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2009
Entry Details
PCBioAssay
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22794BDBM22794(1-benzyl-2,3-dihydro-1H-indole-2,3-dione | Isatin-...)
Affinity DataKi:  870nM ΔG°:  -34.6kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Mississippi

LigandChemical structure of BindingDB Monomer ID 22793BDBM22793(1-phenyl-2,3-dihydro-1H-indole-2,3-dione | 1‐...)
Affinity DataKi:  950nM ΔG°:  -34.4kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
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