Compile Data Set for Download or QSAR
Report error Found 177 of ph data with Target = 'Collagenase 3'
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 30369BDBM30369(piperidinyl glycine derivative, 24f)
Affinity DataKi:  0.190nM ΔG°:  -54.9kJ/mole IC50: 0.5nMpH: 7.5 T: 2°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 50062351BDBM50062351((R)-N*4*-Hydroxy-N*1*-[2-(1H-indol-3-yl)-1-methylc...)
Affinity DataIC50: 0.200nMpH: 7.5 T: 2°CAssay Description:Stock solution of substrate (Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) was prepared in DMSO at a concentration of 6 mM. Assays were performed in an as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 11863BDBM11863(CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...)
Affinity DataKi:  0.280nM ΔG°:  -54.0kJ/mole IC50: 0.300nMpH: 7.5 T: 2°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 30356BDBM30356(BOC-piperidinyl glycine derivative, 31)
Affinity DataIC50: 0.300nMpH: 7.5 T: 2°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 30345BDBM30345(BOC-piperidinyl glycine derivative, 9)
Affinity DataIC50: 0.300nMpH: 7.5 T: 2°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 30359BDBM30359(BOC-piperidinyl glycine derivative, 34)
Affinity DataIC50: 0.5nMpH: 7.5 T: 2°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 30360BDBM30360(BOC-piperidinyl glycine derivative, 35)
Affinity DataIC50: 0.5nMpH: 7.5 T: 2°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 30344BDBM30344(Trocade | Cipemastat)
Affinity DataKi:  0.530nM ΔG°:  -52.4kJ/mole IC50: 3.5nMpH: 7.5 T: 2°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 30367BDBM30367(piperidinyl glycine derivative, 24d)
Affinity DataIC50: 0.600nMpH: 7.5 T: 2°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 50265079BDBM50265079(CHEMBL496942 | 4-{[1-METHYL-2,4-DIOXO-6-(3-PHENYLP...)
Affinity DataIC50: 0.670nMpH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 16596BDBM16596(N,N -bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-di...)
Affinity DataIC50: 0.670nMpH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 30357BDBM30357(BOC-piperidinyl glycine derivative, 32)
Affinity DataIC50: 0.700nMpH: 7.5 T: 2°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 30347BDBM30347(BOC-piperidinyl glycine derivative, 22a)
Affinity DataIC50: 0.75nMpH: 7.5 T: 2°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 30370BDBM30370(piperidinyl glycine derivative, 24g)
Affinity DataIC50: 0.800nMpH: 7.5 T: 2°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 8465BDBM8465(CGS 27023 | CHEMBL514138 | hydroxamate analogue 1 ...)
Affinity DataKi:  1.27nM ΔG°:  -50.3kJ/mole IC50: 1.90nMpH: 7.5 T: 2°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 30364BDBM30364(piperidinyl glycine derivative, 24a)
Affinity DataIC50: 1.30nMpH: 7.5 T: 2°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 32416BDBM32416(furan-2-carboxamide deriv., 28)
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:MMP-13 was assessed by using the EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.). This kit uses a 5-FAM/QXL 520 fluorescence resonance 10 energy tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 30368BDBM30368(piperidinyl glycine derivative, 24e)
Affinity DataIC50: 2.20nMpH: 7.5 T: 2°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 30358BDBM30358(BOC-piperidinyl glycine derivative, 33)
Affinity DataIC50: 2.40nMpH: 7.5 T: 2°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 23498BDBM23498((3S)-4-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}-N-h...)
Affinity DataIC50: 3nMpH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2008
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 30366BDBM30366(piperidinyl glycine derivative, 24c)
Affinity DataIC50: 3.30nMpH: 7.5 T: 2°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 32417BDBM32417(furan-2-carboxamide deriv., 29)
Affinity DataIC50: 4nMpH: 7.5 T: 2°CAssay Description:MMP-13 was assessed by using the EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.). This kit uses a 5-FAM/QXL 520 fluorescence resonance 10 energy tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 24047BDBM24047((2R)-3-methyl-2-[(4-{4-[(3-methyl-1-benzofuran-2-y...)
Affinity DataIC50: 4.40nMpH: 7.5 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2008
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 32412BDBM32412(furan-2-carboxamide deriv., 24)
Affinity DataIC50: 6nMpH: 7.5 T: 2°CAssay Description:MMP-13 was assessed by using the EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.). This kit uses a 5-FAM/QXL 520 fluorescence resonance 10 energy tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 32414BDBM32414(furan-2-carboxamide deriv., 26)
Affinity DataIC50: 6nMpH: 7.5 T: 2°CAssay Description:MMP-13 was assessed by using the EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.). This kit uses a 5-FAM/QXL 520 fluorescence resonance 10 energy tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 30348BDBM30348(BOC-piperidinyl glycine derivative, 22b)
Affinity DataIC50: 6.80nMpH: 7.5 T: 2°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 16596BDBM16596(N,N -bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-di...)
Affinity DataIC50: 8nMpH: 7.5 T: 2°CAssay Description:MMP-13 was assayed its proteolytic activity using a quenched fluorogenic substrate. The substrate hydrolysis was monitored by recording the increase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 30346BDBM30346(piperidinyl glycine derivative, 23)
Affinity DataIC50: 11nMpH: 7.5 T: 2°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 30365BDBM30365(piperidinyl glycine derivative, 24b)
Affinity DataIC50: 12.1nMpH: 7.5 T: 2°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 50098287BDBM50098287(3-Benzyloxy-2-(4'-methoxy-biphenyl-4-sulfonylamino...)
Affinity DataIC50: 14nMpH: 7.4Assay Description:Inhibitory activity against human matrix metalloprotease-13 in quenched fluorescence assay at pH 7.4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 50098275BDBM50098275(2-(4'-Methylsulfanyl-biphenyl-4-sulfonylamino)-5-p...)
Affinity DataIC50: 16nMpH: 7.4Assay Description:Inhibitory activity against human matrix metalloprotease-13 in quenched fluorescence assay at pH 7.4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 26550BDBM26550(2-{[4-(but-2-yn-1-yloxy)benzene](methyl)sulfonamid...)
Affinity DataKi:  17nM ΔG°:  -43.9kJ/molepH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 26550BDBM26550(2-{[4-(but-2-yn-1-yloxy)benzene](methyl)sulfonamid...)
Affinity DataKi:  17nM ΔG°:  -43.9kJ/molepH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 32402BDBM32402(furan-2-carboxamide deriv., 10)
Affinity DataIC50: 17nMpH: 7.5 T: 2°CAssay Description:MMP-13 was assessed by using the EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.). This kit uses a 5-FAM/QXL 520 fluorescence resonance 10 energy tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 92448BDBM92448(Inhibitor, 18)
Affinity DataKi:  18nM ΔG°:  -44.2kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 30352BDBM30352(BOC-piperidinyl glycine derivative, 22f)
Affinity DataIC50: 18nMpH: 7.5 T: 2°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 50098263BDBM50098263(2-(4'-Methoxy-biphenyl-4-sulfonylamino)-5-phenyl-p...)
Affinity DataIC50: 21nMpH: 7.4Assay Description:Inhibitory activity against human matrix metalloprotease-13 in quenched fluorescence assay at pH 7.4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 50098289BDBM50098289(2-(4'-Methoxy-biphenyl-4-sulfonylamino)-6-phenyl-h...)
Affinity DataIC50: 22nMpH: 7.4Assay Description:Inhibitory activity against human matrix metalloprotease-13 in quenched fluorescence assay at pH 7.4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 50098279BDBM50098279(2-(4'-Methoxy-biphenyl-4-sulfonylamino)-5-(3-morph...)
Affinity DataIC50: 24nMpH: 7.4Assay Description:Inhibitory activity against human matrix metalloprotease-13 in quenched fluorescence assay at pH 7.4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 27877BDBM27877(N-{[2-(2-amino-3,4-dioxocyclobut-1-en-1-yl)-1,2,3,...)
Affinity DataIC50: 25nMpH: 7.5 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMPs has been determined by continuously monitoring the hydrolysis of the fluorescent substrate. The hydr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 27878BDBM27878(MMP Inhibitor, 7 | 13-(carbamoylmethyl)-3-oxo-N-[(...)
Affinity DataIC50: 25nMpH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 27878BDBM27878(MMP Inhibitor, 7 | 13-(carbamoylmethyl)-3-oxo-N-[(...)
Affinity DataIC50: 25nMpH: 7.5 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMPs has been determined by continuously monitoring the hydrolysis of the fluorescent substrate. The hydr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 32415BDBM32415(furan-2-carboxamide deriv., 27)
Affinity DataIC50: 25nMpH: 7.5 T: 2°CAssay Description:MMP-13 was assessed by using the EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.). This kit uses a 5-FAM/QXL 520 fluorescence resonance 10 energy tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 32399BDBM32399(furan-2-carboxamide deriv., 7)
Affinity DataIC50: 31nMpH: 7.5 T: 2°CAssay Description:MMP-13 was assessed by using the EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.). This kit uses a 5-FAM/QXL 520 fluorescence resonance 10 energy tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 32411BDBM32411(furan-2-carboxamide deriv., 20)
Affinity DataIC50: 32nMpH: 7.5 T: 2°CAssay Description:MMP-13 was assessed by using the EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.). This kit uses a 5-FAM/QXL 520 fluorescence resonance 10 energy tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 50098280BDBM50098280(2-[5-(4-Methoxy-phenyl)-thiophene-2-sulfonylamino]...)
Affinity DataIC50: 33nMpH: 7.4Assay Description:Inhibitory activity against human matrix metalloprotease-13 in quenched fluorescence assay at pH 7.4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 50098295BDBM50098295(3-Methoxy-2-(4'-methylsulfanyl-biphenyl-4-sulfonyl...)
Affinity DataIC50: 33nMpH: 7.4Assay Description:Inhibitory activity against human matrix metalloprotease-13 in quenched fluorescence assay at pH 7.4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 92444BDBM92444(MMP Inhibitor, 6)
Affinity DataIC50: 33.4nMpH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 50098261BDBM50098261(2-[4-(4-Methoxy-phenylethynyl)-benzenesulfonylamin...)
Affinity DataIC50: 35nMpH: 7.4Assay Description:Inhibitory activity against human matrix metalloprotease-13 in quenched fluorescence assay at pH 7.4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis

LigandChemical structure of BindingDB Monomer ID 24529BDBM24529(2-(benzo[d]isothiazol-3-ylimino)-5-benzylidenethia...)
Affinity DataIC50: 36nMpH: 7.0 T: 2°CAssay Description:The MMP assay were performed evaluating the ability of compounds 1a-6a and 1b-6b to prevent the hydrolysis of the fluorescence-quenched peptide subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2012
Entry Details Article
PubMed
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