Compile Data Set for Download or QSAR
Report error Found 185 of ph data with Target = 'Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1'
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 6878BDBM6878(5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphen...)
Affinity DataIC50: 0.600nMpH: 8.0 T: 2°CAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 6872BDBM6872(4-[[5-Amino-1-[(3-fluoro-2-thienyl)carbonyl]-1H-1,...)
Affinity DataIC50: 2.10nMpH: 8.0 T: 2°CAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 6868BDBM6868(4-[[5-Amino-1-(2,3,6-trifluorobenzoyl)-1H-1,2,4-tr...)
Affinity DataIC50: 3.20nMpH: 8.0 T: 2°CAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 6871BDBM6871(4-({5-amino-1-[(3,5-dimethylthiophen-2-yl)carbonyl...)
Affinity DataIC50: 3.20nMpH: 8.0 T: 2°CAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 6880BDBM6880(3-amino-N-(2,6-difluorophenyl)-5-[(4-sulfamoylphen...)
Affinity DataIC50: 3.20nMpH: 8.0 T: 2°CAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 6877BDBM6877(5-Amino-3-[[4-(aminosulfonyl)phenyl]amino]-N-(2,6-...)
Affinity DataIC50: 3.70nMpH: 8.0 T: 2°CAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 27216BDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)
Affinity DataIC50: 4nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 6869BDBM6869(4-[[5-Amino-1-(2-thienylcarbonyl)-1H-1,2,4-triazol...)
Affinity DataIC50: 4.5nMpH: 8.0 T: 2°CAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 6870BDBM6870(4-({5-amino-1-[(3-methylthiophen-2-yl)carbonyl]-1H...)
Affinity DataIC50: 4.80nMpH: 8.0 T: 2°CAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 5776BDBM5776(4-butoxy-5-[(2,6-difluoro-4-methylphenyl)carbonyl]...)
Affinity DataIC50: 6nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 6866BDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataIC50: 6.40nMpH: 8.0 T: 2°CAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 5779BDBM5779(pyrazolo[3,4-b]pyridine deriv. | 4-butoxy-5-[(2,6...)
Affinity DataIC50: 7nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 7688BDBM7688(4-[1-(5-Oxazol-5-yl-2-oxo-1,2-dihydro-indol-3-ylid...)
Affinity DataIC50: 7.10nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 6867BDBM6867(4-({5-amino-1-[(2,6-difluoro-3-methylphenyl)carbon...)
Affinity DataIC50: 8nMpH: 8.0 T: 2°CAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 7686BDBM7686(4-{2-[(3Z)-5-(1,3-oxazol-5-yl)-2-oxo-2,3-dihydro-1...)
Affinity DataIC50: 10nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 5666BDBM5666(N-(2,6-Difluorophenyl)-N-[5-[[[5-tert-butyl-2-oxaz...)
Affinity DataIC50: 10nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 5777BDBM5777(4-butoxy-5-[(4-chloro-2,6-difluorophenyl)carbonyl]...)
Affinity DataIC50: 13nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 7693BDBM7693(4-{2-[(3Z)-4-(2-methylprop-1-en-1-yl)-2-oxo-2,3-di...)
Affinity DataIC50: 15nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 5778BDBM5778(5-[(4-bromo-2,6-difluorophenyl)carbonyl]-4-butoxy-...)
Affinity DataIC50: 17nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 7687BDBM7687(4-({[(3Z)-5-(1,3-oxazol-5-yl)-2-oxo-2,3-dihydro-1H...)
Affinity DataIC50: 17nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 5664BDBM5664(propan-2-yl N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)m...)
Affinity DataIC50: 18nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 5665BDBM5665(N-[5-[[[5-tert-Butyl-2-oxazolyl]methyl]thio]-2-thi...)
Affinity DataIC50: 19nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 7692BDBM7692(4-{2-[(3Z)-4-(2-methylpropyl)-2-oxo-2,3-dihydro-1H...)
Affinity DataIC50: 19nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 5668BDBM5668(N-[5-[[[5-tert-Butyl-2-oxazolyl]methyl]thio]-2-thi...)
Affinity DataIC50: 30nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 5655BDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50: 30nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 5655BDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50: 30nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 5661BDBM5661(N-[5-[[[5-(Cyclohexylmethyl)-2-oxazolyl]methyl]thi...)
Affinity DataIC50: 30nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 5662BDBM5662(N-[5-[[[5-tert-Butyl-2-oxazolyl]methyl]thio]-2-thi...)
Affinity DataIC50: 30nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 5667BDBM5667(3-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfan...)
Affinity DataIC50: 30nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 5774BDBM5774(4-butoxy-5-[(2,6-difluorophenyl)carbonyl]-1H-pyraz...)
Affinity DataIC50: 32nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 7691BDBM7691(4-[N'-(4-Isopropyl-2-oxo-1,2-dihydro-indol-3-ylide...)
Affinity DataIC50: 37nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 5660BDBM5660(N-[5-[[(5-tert-Butyl-2-oxazolyl)methyl]thio]-2-thi...)
Affinity DataIC50: 40nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 16589BDBM16589(4-[3-(1H-1,3-benzodiazol-2-yl)-1H-indazol-6-yl]-2-...)
Affinity DataIC50: 40nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2007
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 7695BDBM7695(4-{2-[(3Z)-2-oxo-4-(propan-2-yloxy)-2,3-dihydro-1H...)
Affinity DataIC50: 41nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 6865BDBM6865(4-[(5-Amino-1-benzoyl-1H-1,2,4-triazol-3-yl)amino]...)
Affinity DataIC50: 45nMpH: 8.0 T: 2°CAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 7690BDBM7690(4-[2-(4-Ethyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene...)
Affinity DataIC50: 46nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 11460BDBM11460(2-N-(4-aminocyclohexyl)-6-N-benzyl-9-cyclopentyl-9...)
Affinity DataIC50: 52nMpH: 8.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 0.5 uM ATP/ [gamma-33P] ATP. Af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 5669BDBM5669(N-[5-[[(5-Ethyl-2-oxazolyl)methyl]thio]-2-thiazoly...)
Affinity DataIC50: 60nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 5659BDBM5659(N-[5-[[[5-Isopropyl-2-oxazolyl]methyl]thio]-2-thia...)
Affinity DataIC50: 60nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 11459BDBM11459(2,6,9-trisubstituted adenine derivative | 2-N-(4-a...)
Affinity DataIC50: 70nMpH: 8.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 0.5 uM ATP/ [gamma-33P] ATP. Af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 27217BDBM27217(GP0210 | (2R)-2-{[4-(benzylamino)-8-(propan-2-yl)p...)
Affinity DataIC50: 73nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 27218BDBM27218((2R)-2-({4-[(3-chlorophenyl)amino]-8-(propan-2-yl)...)
Affinity DataIC50: 80nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 5670BDBM5670(N-[5-[[(5-Ethyl-2-oxazolyl)methyl]thio]-2-thiazoly...)
Affinity DataIC50: 80nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 5714BDBM5714((+/-)-(3SR,4RS)-2-(tert-Butylthio)-5,7-dihydroxy-8...)
Affinity DataIC50: 80nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 8061BDBM8061(4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-(3-nitroph...)
Affinity DataKi:  80nM ΔG°:  -41.2kJ/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 5663BDBM5663(N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfan...)
Affinity DataIC50: 90nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 5775BDBM5775(4-butoxy-5-[(2,4,6-trifluorophenyl)carbonyl]-1H-py...)
Affinity DataIC50: 92nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 5710BDBM5710(2-[(2-chlorophenyl)sulfanyl]-5,7-dihydroxy-8-[(3S,...)
Affinity DataIC50: 110nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 7689BDBM7689(4-[N'-(4-Iodo-2-oxo-1,2-dihydro-indol-3-ylidene)-h...)
Affinity DataIC50: 110nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 8397BDBM8397(4-{[3-(4-bromophenyl)-1H-pyrazol-5-yl]amino}benzen...)
Affinity DataIC50: 126nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2006
Entry Details Article
PubMed
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