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Found 59 of ph data with Target = 'Cytochrome P450 2A6'
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM12341(CHEMBL178681 | CHEMBL359657 | US8609708, 1 | US860...)
Affinity DataKi:  80nM ΔG°:  -42.1kJ/molepH: 7.5 T: 2°CAssay Description:To measure CYP2A6 activity, coumarin 7-hydroxylation was determined. The formation of the coumarin metabolite, 7-hydroxycoumarin, was determined fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM12345(CHEMBL178090 | US8609708, 2 | US8609708, 47 | [5-(...)
Affinity DataKi:  100nM ΔG°:  -41.6kJ/molepH: 7.5 T: 2°CAssay Description:To measure CYP2A6 activity, coumarin 7-hydroxylation was determined. The formation of the coumarin metabolite, 7-hydroxycoumarin, was determined fluo...More data for this Ligand-Target Pair
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM12351(3-(3-methylthiophen-2-yl)pyridine | CHEMBL179669 |...)
Affinity DataKi:  300nM ΔG°:  -38.7kJ/molepH: 7.5 T: 2°CAssay Description:To measure CYP2A6 activity, coumarin 7-hydroxylation was determined. The formation of the coumarin metabolite, 7-hydroxycoumarin, was determined fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM12348(3-(pyridin-3-yl)prop-2-yn-1-amine | CHEMBL360541 |...)
Affinity DataKi:  300nM ΔG°:  -38.7kJ/molepH: 7.5 T: 2°CAssay Description:To measure CYP2A6 activity, coumarin 7-hydroxylation was determined. The formation of the coumarin metabolite, 7-hydroxycoumarin, was determined fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM12352(3-(1-methyl-1H-imidazol-4-yl)pyridine | CHEMBL3609...)
Affinity DataKi:  400nM ΔG°:  -38.0kJ/molepH: 7.5 T: 2°CAssay Description:To measure CYP2A6 activity, coumarin 7-hydroxylation was determined. The formation of the coumarin metabolite, 7-hydroxycoumarin, was determined fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM12353(3-(5-methyl-1H-imidazol-1-yl)pyridine | nicotine 3...)
Affinity DataKi:  500nM ΔG°:  -37.4kJ/molepH: 7.5 T: 2°CAssay Description:To measure CYP2A6 activity, coumarin 7-hydroxylation was determined. The formation of the coumarin metabolite, 7-hydroxycoumarin, was determined fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM12343(CHEMBL369285 | US8609708, 9 | methyl({[5-(pyridin-...)
Affinity DataKi:  600nM ΔG°:  -36.9kJ/molepH: 7.5 T: 2°CAssay Description:To measure CYP2A6 activity, coumarin 7-hydroxylation was determined. The formation of the coumarin metabolite, 7-hydroxycoumarin, was determined fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM12354(2-fluoro-5-(3-methylthiophen-2-yl)pyridine | CHEMB...)
Affinity DataKi:  600nM ΔG°:  -36.9kJ/molepH: 7.5 T: 2°CAssay Description:To measure CYP2A6 activity, coumarin 7-hydroxylation was determined. The formation of the coumarin metabolite, 7-hydroxycoumarin, was determined fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM12356(3-(2-methyl-1H-imidazol-1-yl)pyridine | CHEMBL3688...)
Affinity DataKi:  700nM ΔG°:  -36.5kJ/molepH: 7.5 T: 2°CAssay Description:To measure CYP2A6 activity, coumarin 7-hydroxylation was determined. The formation of the coumarin metabolite, 7-hydroxycoumarin, was determined fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM12355(3-(thiophen-3-yl)pyridine | CHEMBL361153 | US86097...)
Affinity DataKi:  700nM ΔG°:  -36.5kJ/molepH: 7.5 T: 2°CAssay Description:To measure CYP2A6 activity, coumarin 7-hydroxylation was determined. The formation of the coumarin metabolite, 7-hydroxycoumarin, was determined fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM12346(CHEMBL178938 | US8609708,16 | methyl({[5-(pyridin-...)
Affinity DataKi:  800nM ΔG°:  -36.2kJ/molepH: 7.5 T: 2°CAssay Description:To measure CYP2A6 activity, coumarin 7-hydroxylation was determined. The formation of the coumarin metabolite, 7-hydroxycoumarin, was determined fluo...More data for this Ligand-Target Pair
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM12349(CHEMBL149808 | US8609708, 26 | methyl[3-(pyridin-3...)
Affinity DataKi:  2.70E+3nM ΔG°:  -33.1kJ/molepH: 7.5 T: 2°CAssay Description:To measure CYP2A6 activity, coumarin 7-hydroxylation was determined. The formation of the coumarin metabolite, 7-hydroxycoumarin, was determined fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM12347(CHEMBL360998 | US8609708, 56 | dimethyl({[5-(pyrid...)
Affinity DataKi:  1.42E+4nM ΔG°:  -28.8kJ/molepH: 7.5 T: 2°CAssay Description:To measure CYP2A6 activity, coumarin 7-hydroxylation was determined. The formation of the coumarin metabolite, 7-hydroxycoumarin, was determined fluo...More data for this Ligand-Target Pair
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM12344(CHEMBL361969 | US8609708, 75 | dimethyl({[5-(pyrid...)
Affinity DataKi:  6.65E+4nM ΔG°:  -24.8kJ/molepH: 7.5 T: 2°CAssay Description:To measure CYP2A6 activity, coumarin 7-hydroxylation was determined. The formation of the coumarin metabolite, 7-hydroxycoumarin, was determined fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM12350(CHEMBL180270 | US8609708, 76 | dimethyl[3-(pyridin...)
Affinity DataKi:  6.75E+4nM ΔG°:  -24.8kJ/molepH: 7.5 T: 2°CAssay Description:To measure CYP2A6 activity, coumarin 7-hydroxylation was determined. The formation of the coumarin metabolite, 7-hydroxycoumarin, was determined fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM12341(CHEMBL178681 | CHEMBL359657 | US8609708, 1 | US860...)
Affinity DataIC50:  160nMpH: 7.5Assay Description:To gain insight into the selectivity of the synthetic compounds for inhibition of other CYPs, we examined the major CYPs present in human liver. Prio...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM50188097(1-(4-Chlorobenzyl)-1H-imidazole | CHEMBL441367)
Affinity DataIC50:  160nMpH: 7.5Assay Description:To gain insight into the selectivity of the synthetic compounds for inhibition of other CYPs, we examined the major CYPs present in human liver. Prio...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM12351(3-(3-methylthiophen-2-yl)pyridine | CHEMBL179669 |...)
Affinity DataIC50:  200nMpH: 7.5Assay Description:To gain insight into the selectivity of the synthetic compounds for inhibition of other CYPs, we examined the major CYPs present in human liver. Prio...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM12345(CHEMBL178090 | US8609708, 2 | US8609708, 47 | [5-(...)
Affinity DataIC50:  200nMpH: 7.5Assay Description:To gain insight into the selectivity of the synthetic compounds for inhibition of other CYPs, we examined the major CYPs present in human liver. Prio...More data for this Ligand-Target Pair
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM12370((3-(Pyridin-3-yl)-1H-pyrazol-5-yl)methanamine | [3...)
Affinity DataIC50:  600nMpH: 7.5Assay Description:To gain insight into the selectivity of the synthetic compounds for inhibition of other CYPs, we examined the major CYPs present in human liver. Prio...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM12371((3-(Pyridin-3-yl)isoxazol-5-yl)methanamine Dihydro...)
Affinity DataIC50:  800nMpH: 7.5Assay Description:To gain insight into the selectivity of the synthetic compounds for inhibition of other CYPs, we examined the major CYPs present in human liver. Prio...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM84668(1-Subsituted 1H-imidazole, 3)
Affinity DataIC50:  2.10E+3nMpH: 7.6 T: 2°CAssay Description:Inhibition assay using cytochrome P450 enzyme CYP2A6 and CYP2A13.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM84669(1-Subsituted 1H-imidazole, 4)
Affinity DataIC50:  2.70E+3nMpH: 7.6 T: 2°CAssay Description:Inhibition assay using cytochrome P450 enzyme CYP2A6 and CYP2A13.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM84671(1-Subsituted 1H-imidazole, 7)
Affinity DataIC50:  3.10E+3nMpH: 7.6 T: 2°CAssay Description:Inhibition assay using cytochrome P450 enzyme CYP2A6 and CYP2A13.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM84677(1-Subsituted 1H-imidazole, 14)
Affinity DataIC50:  5.70E+3nMpH: 7.6 T: 2°CAssay Description:Inhibition assay using cytochrome P450 enzyme CYP2A6 and CYP2A13.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM84673(1-Subsituted 1H-imidazole, 10)
Affinity DataIC50:  6.70E+3nMpH: 7.6 T: 2°CAssay Description:Inhibition assay using cytochrome P450 enzyme CYP2A6 and CYP2A13.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM84674(1-Subsituted 1H-imidazole, 11 | 1-Subsituted 1H-im...)
Affinity DataIC50:  7.10E+3nMpH: 7.6 T: 2°CAssay Description:Inhibition assay using cytochrome P450 enzyme CYP2A6 and CYP2A13.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM84672(1-Subsituted 1H-imidazole, 9)
Affinity DataIC50:  7.70E+3nMpH: 7.6 T: 2°CAssay Description:Inhibition assay using cytochrome P450 enzyme CYP2A6 and CYP2A13.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM84695(2-Subsituted pyrazine, 35)
Affinity DataIC50:  1.03E+4nMpH: 7.6 T: 2°CAssay Description:Inhibition assay using cytochrome P450 enzyme CYP2A6 and CYP2A13.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM84670(1-Subsituted 1H-imidazole, 5)
Affinity DataIC50:  1.10E+4nMpH: 7.6 T: 2°CAssay Description:Inhibition assay using cytochrome P450 enzyme CYP2A6 and CYP2A13.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM84693(2-Subsituted pyrazine, 33)
Affinity DataIC50:  1.12E+4nMpH: 7.6 T: 2°CAssay Description:Inhibition assay using cytochrome P450 enzyme CYP2A6 and CYP2A13.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM84674(1-Subsituted 1H-imidazole, 11 | 1-Subsituted 1H-im...)
Affinity DataIC50:  1.15E+4nMpH: 7.6 T: 2°CAssay Description:Inhibition assay using cytochrome P450 enzyme CYP2A6 and CYP2A13.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM84676(1-Subsituted 1H-imidazole, 13)
Affinity DataIC50:  1.40E+4nMpH: 7.6 T: 2°CAssay Description:Inhibition assay using cytochrome P450 enzyme CYP2A6 and CYP2A13.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM84685(1-Subsituted 1H-imidazole, 22)
Affinity DataIC50:  2.24E+4nMpH: 7.6 T: 2°CAssay Description:Inhibition assay using cytochrome P450 enzyme CYP2A6 and CYP2A13.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM84694(2-Subsituted pyrazine, 34)
Affinity DataIC50:  2.38E+4nMpH: 7.6 T: 2°CAssay Description:Inhibition assay using cytochrome P450 enzyme CYP2A6 and CYP2A13.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM21358(2-[1-({6-chloroimidazo[2,1-b][1,3]thiazole-5-}sulf...)
Affinity DataIC50:  4.10E+4nMpH: 7.4 T: 2°CAssay Description:The effect of compound on cytochrome P450 (CYP) enzyme catalytic activity was determined in human liver microsomes, using a cocktail of probe substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM50149347(1-Cyclopropylmethyl-1H-imidazole | 1-Subsituted 1H...)
Affinity DataIC50:  5.40E+4nMpH: 7.6 T: 2°CAssay Description:Inhibition assay using cytochrome P450 enzyme CYP2A6 and CYP2A13.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM84678(1-Subsituted 1H-imidazole, 15)
Affinity DataIC50:  6.40E+4nMpH: 7.6 T: 2°CAssay Description:Inhibition assay using cytochrome P450 enzyme CYP2A6 and CYP2A13.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM36010(1-Subsituted 1H-imidazole, 2 | 1-butylimidazole)
Affinity DataIC50:  8.60E+4nMpH: 7.6 T: 2°CAssay Description:Inhibition assay using cytochrome P450 enzyme CYP2A6 and CYP2A13.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM84667(1-Subsituted 1H-imidazole, 1)
Affinity DataIC50:  1.10E+5nMpH: 7.6 T: 2°CAssay Description:Inhibition assay using cytochrome P450 enzyme CYP2A6 and CYP2A13.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM84696(2-Subsituted pyrazine, 36)
Affinity DataIC50:  1.15E+5nMpH: 7.6 T: 2°CAssay Description:Inhibition assay using cytochrome P450 enzyme CYP2A6 and CYP2A13.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM84683(1-Subsituted 1H-imidazole, 20)
Affinity DataIC50:  1.22E+5nMpH: 7.6 T: 2°CAssay Description:Inhibition assay using cytochrome P450 enzyme CYP2A6 and CYP2A13.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM84679(1-Subsituted 1H-imidazole, 16)
Affinity DataIC50:  1.36E+5nMpH: 7.6 T: 2°CAssay Description:Inhibition assay using cytochrome P450 enzyme CYP2A6 and CYP2A13.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM50149352(1-Cyclohexylmethyl-1H-imidazole | CHEMBL120057)
Affinity DataIC50:  1.70E+5nMpH: 7.5Assay Description:To gain insight into the selectivity of the synthetic compounds for inhibition of other CYPs, we examined the major CYPs present in human liver. Prio...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM84684(1-Subsituted 1H-imidazole, 21 | CHEMBL543494)
Affinity DataIC50:  1.78E+5nMpH: 7.6 T: 2°CAssay Description:Inhibition assay using cytochrome P450 enzyme CYP2A6 and CYP2A13.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM45885(3-(1-imidazolylmethyl)pyridine | 3-(imidazol-1-ylm...)
Affinity DataIC50: >2.00E+5nMpH: 7.5Assay Description:To gain insight into the selectivity of the synthetic compounds for inhibition of other CYPs, we examined the major CYPs present in human liver. Prio...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM84689(2-Subsituted 1H-imidazole, 28)
Affinity DataIC50: >3.00E+5nMpH: 7.6 T: 2°CAssay Description:Inhibition assay using cytochrome P450 enzyme CYP2A6 and CYP2A13.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM84688(2-Subsituted 1H-imidazole, 27)
Affinity DataIC50: >3.00E+5nMpH: 7.6 T: 2°CAssay Description:Inhibition assay using cytochrome P450 enzyme CYP2A6 and CYP2A13.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM84687(2-Subsituted 1H-imidazole, 26)
Affinity DataIC50: >3.00E+5nMpH: 7.6 T: 2°CAssay Description:Inhibition assay using cytochrome P450 enzyme CYP2A6 and CYP2A13.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM84686(2-Subsituted 1H-imidazole, 23)
Affinity DataIC50: >3.00E+5nMpH: 7.6 T: 2°CAssay Description:Inhibition assay using cytochrome P450 enzyme CYP2A6 and CYP2A13.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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