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Report error Found 13 of ph data with Target = 'Cytochrome P450 2C8'
TargetCytochrome P450 2C8(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM191369(example 8A disclosed in WO 2005/082863 | WO2005082...)
Affinity DataIC50: 1.09E+4nMpH: 7.5 T: 2°CAssay Description:Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach...More data for this Ligand-Target Pair
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Date in BDB:
5/19/2018
Entry Details
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TargetCytochrome P450 2C8(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM50305083(Ko143 | Ko-143 | 3-((3S,6S)-6-Isobutyl-9-methoxy-1...)
Affinity DataIC50: 3.00E+4nMpH: 7.4 T: 2°CAssay Description:Human liver microsomes (HLMs) (0.3 mg/mL in 0.1-M potassium phosphate buffer, pH 7.4) are incubated with CYP (cytochromes P450) isozyme-selective sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2018
Entry Details
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TargetCytochrome P450 2C8(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM106203(US9695174, I-1)
Affinity DataIC50: 3.00E+4nMpH: 7.4 T: 2°CAssay Description:Human liver microsomes (HLMs) (0.3 mg/mL in 0.1-M potassium phosphate buffer, pH 7.4) are incubated with CYP (cytochromes P450) isozyme-selective sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2018
Entry Details
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TargetCytochrome P450 2C8(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM155255(US9006242, 105 | US10098888, Compound 105 | US1164...)
Affinity DataIC50: 4.74E+4nMpH: 7.4Assay Description:The potential inhibition of enzyme activities of human cytochromes P450 (CYP) of Compound 1, 2, or 105 was evaluated using pooled human liver microso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2015
Entry Details
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TargetCytochrome P450 2C8(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM50120423(US9290459, 1A | US9670166, 1A | CHEMBL3617971)
Affinity DataIC50: 5.00E+4nMpH: 7.5 T: 2°CAssay Description:Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
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TargetCytochrome P450 2C8(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM211757(US9290459, 47.21 | US9290459, 10A | US9670166, 10A)
Affinity DataIC50: 5.00E+4nMpH: 7.5 T: 2°CAssay Description:Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
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TargetCytochrome P450 2C8(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM211754(US9290459, 9A | US9670166, 9A)
Affinity DataIC50: 5.00E+4nMpH: 7.5 T: 2°CAssay Description:Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
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TargetCytochrome P450 2C8(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM211750(US9290459, 7.2A | US9670166, 7.2A)
Affinity DataIC50: 5.00E+4nMpH: 7.5 T: 2°CAssay Description:Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
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TargetCytochrome P450 2C8(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM211836(US9290459, 41A | US9670166, 41A)
Affinity DataIC50: 5.00E+4nMpH: 7.5 T: 2°CAssay Description:Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
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TargetCytochrome P450 2C8(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM50120439(US9290459, 47.1 | US9670166, 47.1 | CHEMBL3617975)
Affinity DataIC50: 5.00E+4nMpH: 7.5 T: 2°CAssay Description:Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
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TargetCytochrome P450 2C8(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM211887(US9290459, 47.2 | US9670166, 47.2)
Affinity DataIC50: 5.00E+4nMpH: 7.5 T: 2°CAssay Description:Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
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TargetCytochrome P450 2C8(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM155253(US9006242, 1 | US10098888, Compound 1)
Affinity DataIC50: 1.00E+5nMpH: 7.4Assay Description:The potential inhibition of enzyme activities of human cytochromes P450 (CYP) of Compound 1, 2, or 105 was evaluated using pooled human liver microso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2015
Entry Details
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TargetCytochrome P450 2C8(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM155254(US9006242, 2 | US10098888, Compound 2)
Affinity DataIC50: 1.00E+5nMpH: 7.4Assay Description:The potential inhibition of enzyme activities of human cytochromes P450 (CYP) of Compound 1, 2, or 105 was evaluated using pooled human liver microso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2015
Entry Details
Go to US Patent