Compile Data Set for Download or QSAR
Report error Found 25 of ph data with Target = 'Cytochrome P450 2C9'
TargetCytochrome P450 2C9(Human)
Brickell Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 50090677BDBM50090677(CHEMBL1109 | 4-Amino-N-(2-phenyl-2H-pyrazol-3-yl)-...)
Affinity DataIC50: 210nMpH: 7.4Assay Description:Specific aspects of the incubation conditions for each assay (e.g., protein concentration, incubation time, etc.) are defined in Walsky & Obach, 2004...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Brickell Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 26470BDBM26470(3-({4-[(2-benzyl-3-methyl-2H-indazol-6-yl)(methyl)...)
Affinity DataIC50: 500nMpH: 7.4 T: 2°CAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Brickell Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 26467BDBM26467(3-({4-[methyl(3-methyl-1H-indazol-6-yl)amino]pyrim...)
Affinity DataIC50: 700nMpH: 7.4 T: 2°CAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Brickell Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 26468BDBM26468(3-({4-[(1,3-dimethyl-1H-indazol-6-yl)(methyl)amino...)
Affinity DataIC50: 1.00E+3nMpH: 7.4 T: 2°CAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Brickell Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 26469BDBM26469(3-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino...)
Affinity DataIC50: 1.40E+3nMpH: 7.4 T: 2°CAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Brickell Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 26471BDBM26471(3-({4-[methyl(2-methyl-2H-indazol-6-yl)amino]pyrim...)
Affinity DataIC50: 2.90E+3nMpH: 7.4 T: 2°CAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Brickell Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 50305083BDBM50305083(Ko143 | Ko-143 | 3-((3S,6S)-6-Isobutyl-9-methoxy-1...)
Affinity DataIC50: 6.00E+3nMpH: 7.4 T: 2°CAssay Description:Human liver microsomes (HLMs) (0.3 mg/mL in 0.1-M potassium phosphate buffer, pH 7.4) are incubated with CYP (cytochromes P450) isozyme-selective sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2018
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Brickell Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 26473BDBM26473(3-({4-[(1,2-dimethyl-1H-1,3-benzodiazol-5-yl)(meth...)
Affinity DataIC50: 9.00E+3nMpH: 7.4 T: 2°CAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Brickell Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 191369BDBM191369(example 8A disclosed in WO 2005/082863 | WO2005082...)
Affinity DataIC50: 1.20E+4nMpH: 7.5 T: 2°CAssay Description:Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Brickell Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 26472BDBM26472(3-({4-[(1,2-dimethyl-1H-1,3-benzodiazol-6-yl)(meth...)
Affinity DataIC50: 1.50E+4nMpH: 7.4 T: 2°CAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Brickell Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 7841BDBM7841(BAY 59-7939 Analog 18 | US8822458, 45 | US9359341,...)
Affinity DataIC50: 1.67E+4nMpH: 7.4 T: 2°CAssay Description:Incubation of phenacetin, diclofenac, dextromethorphan, mephenotoin, albendazole and testosterone with human liver microsomes in the presence of in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Brickell Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 235143BDBM235143(US9359341, Formula B)
Affinity DataIC50: 2.24E+4nMpH: 7.4 T: 2°CAssay Description:Incubation of phenacetin, diclofenac, dextromethorphan, mephenotoin, albendazole and testosterone with human liver microsomes in the presence of in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Brickell Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 211750BDBM211750(US9290459, 7.2A | US9670166, 7.2A)
Affinity DataIC50: 5.00E+4nMpH: 7.5 T: 2°CAssay Description:Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Brickell Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 211754BDBM211754(US9290459, 9A | US9670166, 9A)
Affinity DataIC50: 5.00E+4nMpH: 7.5 T: 2°CAssay Description:Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Brickell Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 50120439BDBM50120439(US9290459, 47.1 | US9670166, 47.1 | CHEMBL3617975)
Affinity DataIC50: 5.00E+4nMpH: 7.5 T: 2°CAssay Description:Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Brickell Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 211836BDBM211836(US9290459, 41A | US9670166, 41A)
Affinity DataIC50: 5.00E+4nMpH: 7.5 T: 2°CAssay Description:Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Brickell Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 211757BDBM211757(US9290459, 47.21 | US9290459, 10A | US9670166, 10A)
Affinity DataIC50: 5.00E+4nMpH: 7.5 T: 2°CAssay Description:Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Brickell Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 164620BDBM164620(US9688624, Compound 2)
Affinity DataIC50: 5.00E+4nMpH: 7.4Assay Description:Specific aspects of the incubation conditions for each assay (e.g., protein concentration, incubation time, etc.) are defined in Walsky & Obach, 2004...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Brickell Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 50120423BDBM50120423(US9290459, 1A | US9670166, 1A | CHEMBL3617971)
Affinity DataIC50: 5.00E+4nMpH: 7.5 T: 2°CAssay Description:Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Brickell Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 211887BDBM211887(US9290459, 47.2 | US9670166, 47.2)
Affinity DataIC50: 5.00E+4nMpH: 7.5 T: 2°CAssay Description:Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Brickell Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 155255BDBM155255(US9006242, 105 | US10098888, Compound 105 | US1164...)
Affinity DataIC50: 7.57E+4nMpH: 7.4Assay Description:The potential inhibition of enzyme activities of human cytochromes P450 (CYP) of Compound 1, 2, or 105 was evaluated using pooled human liver microso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2015
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Brickell Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 155254BDBM155254(US9006242, 2 | US10098888, Compound 2)
Affinity DataIC50: 1.00E+5nMpH: 7.4Assay Description:The potential inhibition of enzyme activities of human cytochromes P450 (CYP) of Compound 1, 2, or 105 was evaluated using pooled human liver microso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2015
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Brickell Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 155253BDBM155253(US9006242, 1 | US10098888, Compound 1)
Affinity DataIC50: 1.00E+5nMpH: 7.4Assay Description:The potential inhibition of enzyme activities of human cytochromes P450 (CYP) of Compound 1, 2, or 105 was evaluated using pooled human liver microso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2015
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Brickell Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 21358BDBM21358(2-[1-({6-chloroimidazo[2,1-b][1,3]thiazole-5-}sulf...)
Affinity DataIC50: 5.00E+5nMpH: 7.4 T: 2°CAssay Description:The effect of compound on cytochrome P450 (CYP) enzyme catalytic activity was determined in human liver microsomes, using a cocktail of probe substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Brickell Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 106203BDBM106203(US9695174, I-1)
Affinity DatapH: 7.4 T: 2°CAssay Description:Human liver microsomes (HLMs) (0.3 mg/mL in 0.1-M potassium phosphate buffer, pH 7.4) are incubated with CYP (cytochromes P450) isozyme-selective sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2018
Entry Details
US Patent