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Found 472 of ph data with Target = 'Cytochrome P450 3A4'
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM144637(US8952036, Ex. 5)
Affinity DataIC50:  0.0503nMpH: 7.4 T: 2°CAssay Description:The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50448963(CHEMBL3125537 | US9296736, 351 | US9593129, Exampl...)
Affinity DataIC50:  0.0962nMpH: 7.4 T: 2°CAssay Description:The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM144636(US8952036, Ex. 4)
Affinity DataIC50:  0.102nMpH: 7.4 T: 2°CAssay Description:The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM144638(US8952036, Ex. 3)
Affinity DataIC50:  0.330nMpH: 7.4 T: 2°CAssay Description:The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50008760(CHEMBL3236364)
Affinity DataIC50:  1.83nMpH: 7.4 T: 2°CAssay Description:The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50220136(3-[2-{1-[3,5-di(trifluoromethyl)phenyl]ethoxy}-3-(...)
Affinity DataIC50:  20nMpH: 7.4 T: 2°CAssay Description:A dimethyl sulfoxide (DMSO) solution of a test compound with a concentration 1000 times higher than the evaluation concentration was prepared, and a ...More data for this Ligand-Target Pair
In DepthDetails US PatentDrugBank

TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM151585(US11739089, Compound Ketoconazole | US8987315, Ket...)
Affinity DataIC50:  20nMpH: 7.4Assay Description:Specific aspects of the incubation conditions for each assay (e.g., protein concentration, incubation time, etc.) are defined in Walsky & Obach, 2004...More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM151585(US11739089, Compound Ketoconazole | US8987315, Ket...)
Affinity DataIC50:  20nMpH: 7.4Assay Description:Specific aspects of the incubation conditions for each assay (e.g., protein concentration, incubation time, etc.) are defined in Walsky & Obach, 2004...More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50220136(3-[2-{1-[3,5-di(trifluoromethyl)phenyl]ethoxy}-3-(...)
Affinity DataIC50:  20nMpH: 7.4 T: 2°CAssay Description:A dimethyl sulfoxide (DMSO) solution of a test compound with a concentration 1000 times higher than the evaluation concentration was prepared, and a ...More data for this Ligand-Target Pair
In DepthDetails US PatentDrugBank

TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM21164(1-[2-(4-methoxyphenyl)-2-[3-(4-methoxyphenyl)propo...)
Affinity DataIC50:  45nMpH: 7.4 T: 2°CAssay Description:The inhibition of recombinant human CYP3A4 was measured as the ability to perform a debenzylation of 7-benzyloxy-4-trifluoromethylcoumarin (BFC). Bef...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM27879(4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-...)
Affinity DataIC50:  50nMpH: 7.4 T: 2°CAssay Description:The inhibition of recombinant human CYP3A4 was measured as the ability to perform a dealkylation of 7-benzyloxy-4-trifluoromethylcoumarin (BFC). Befo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM21170(1-[2-(2,4-dichlorophenoxy)-2-(2,4-dichlorophenyl)e...)
Affinity DataIC50:  60nMpH: 7.4 T: 2°CAssay Description:The inhibition of recombinant human CYP3A4 was measured as the ability to perform a debenzylation of 7-benzyloxy-4-trifluoromethylcoumarin (BFC). Bef...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM21160(N-[(5-methylpyrimidin-2-yl)methyl]-6-phenyl-2-(pyr...)
Affinity DataIC50:  71nMpH: 7.4 T: 2°CAssay Description:The inhibition of recombinant human CYP3A4 was measured as the ability to perform a debenzylation of 7-benzyloxy-4-trifluoromethylcoumarin (BFC). Bef...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM21165(1-{[4-bromo-2-(2,4-dichlorophenyl)oxolan-2-yl]meth...)
Affinity DataIC50:  130nMpH: 7.4 T: 2°CAssay Description:The inhibition of recombinant human CYP3A4 was measured as the ability to perform a debenzylation of 7-benzyloxy-4-trifluoromethylcoumarin (BFC). Bef...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM21166(1-{[2-(2,4-dichlorophenyl)-4-ethyl-1,3-dioxolan-2-...)
Affinity DataIC50:  210nMpH: 7.4 T: 2°CAssay Description:The inhibition of recombinant human CYP3A4 was measured as the ability to perform a debenzylation of 7-benzyloxy-4-trifluoromethylcoumarin (BFC). Bef...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM21162(4-{1-[(2,4-dichlorophenyl)methyl]-1H-pyrazol-4-yl}...)
Affinity DataIC50:  230nMpH: 7.4 T: 2°CAssay Description:The inhibition of recombinant human CYP3A4 was measured as the ability to perform a debenzylation of 7-benzyloxy-4-trifluoromethylcoumarin (BFC). Bef...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50381698(CHEMBL1969102 | US8722890, 6)
Affinity DataIC50:  300nMpH: 7.4 T: 2°CAssay Description:Assays (200 μL final volume) were carried out in NUNC polypropylene deep well plates in 50 mM potassium phosphate buffer, pH 7.4, using a microt...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM183991(US9150566, 28)
Affinity DataIC50:  300nMpH: 7.4 T: 2°CAssay Description:The CYP3A4 inhibition assay was performed using human liver microsomes and testosterone 6'-hydroxylation as a P450 isoform-specific marker. In a tota...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM184155(US9150566, 193)
Affinity DataIC50:  600nMpH: 7.4 T: 2°CAssay Description:The CYP3A4 inhibition assay was performed using human liver microsomes and testosterone 6'-hydroxylation as a P450 isoform-specific marker. In a tota...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50381698(CHEMBL1969102 | US8722890, 6)
Affinity DataIC50:  760nMpH: 7.4 T: 2°CAssay Description:Assays (200 μL final volume) were carried out in NUNC polypropylene deep well plates in 50 mM potassium phosphate buffer, pH 7.4, using a microt...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM143070(US8940739, F-29)
Affinity DataIC50:  1.10E+3nMpH: 7.4Assay Description:This assay was performed in a 200 l volume in 96-well microtiter plates using cDNA-expressed human hepatic CYP3A4 (supersome, BD Gentest #456202). As...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM184006(US9150566, 43)
Affinity DataIC50:  1.20E+3nMpH: 7.4 T: 2°CAssay Description:The CYP3A4 inhibition assay was performed using human liver microsomes and testosterone 6'-hydroxylation as a P450 isoform-specific marker. In a tota...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM183967(US9150566, 4)
Affinity DataIC50:  1.20E+3nMpH: 7.4 T: 2°CAssay Description:The CYP3A4 inhibition assay was performed using human liver microsomes and testosterone 6'-hydroxylation as a P450 isoform-specific marker. In a tota...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM21157(4-(methanesulfonylmethyl)-2-(pyridin-4-yl)-6-(pyrr...)
Affinity DataIC50:  1.30E+3nMpH: 7.4 T: 2°CAssay Description:The inhibition of recombinant human CYP3A4 was measured as the ability to perform a debenzylation of 7-benzyloxy-4-trifluoromethylcoumarin (BFC). Bef...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM21149(4-[5-(benzylsulfanyl)-4-(4-bromophenyl)-4H-1,2,4-t...)
Affinity DataIC50:  1.30E+3nMpH: 7.4 T: 2°CAssay Description:The inhibition of recombinant human CYP3A4 was measured as the ability to perform a debenzylation of 7-benzyloxy-4-trifluoromethylcoumarin (BFC). Bef...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM292013(US10100030, Example 8)
Affinity DataIC50:  1.40E+3nMpH: 7.4 T: 2°CAssay Description:A dimethyl sulfoxide (DMSO) solution of a test compound with a concentration 1000 times higher than the evaluation concentration was prepared, and a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM21168(Imidazole-based ligand, 19 | methyl (2S)-2-(benzyl...)
Affinity DataIC50:  1.50E+3nMpH: 7.4 T: 2°CAssay Description:The inhibition of recombinant human CYP3A4 was measured as the ability to perform a debenzylation of 7-benzyloxy-4-trifluoromethylcoumarin (BFC). Bef...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM142935(US8940739, D-5)
Affinity DataIC50:  1.76E+3nMpH: 7.4Assay Description:This assay was performed in a 200 l volume in 96-well microtiter plates using cDNA-expressed human hepatic CYP3A4 (supersome, BD Gentest #456202). As...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM184007(US9150566, 44)
Affinity DataIC50:  2.00E+3nMpH: 7.4 T: 2°CAssay Description:The CYP3A4 inhibition assay was performed using human liver microsomes and testosterone 6'-hydroxylation as a P450 isoform-specific marker. In a tota...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM143053(US8940739, F-10)
Affinity DataIC50:  2.01E+3nMpH: 7.4Assay Description:This assay was performed in a 200 l volume in 96-well microtiter plates using cDNA-expressed human hepatic CYP3A4 (supersome, BD Gentest #456202). As...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM143079(US8940739, F-47)
Affinity DataIC50:  2.05E+3nMpH: 7.4Assay Description:This assay was performed in a 200 l volume in 96-well microtiter plates using cDNA-expressed human hepatic CYP3A4 (supersome, BD Gentest #456202). As...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM143173(US8940739, H-6)
Affinity DataIC50:  2.09E+3nMpH: 7.4Assay Description:This assay was performed in a 200 l volume in 96-well microtiter plates using cDNA-expressed human hepatic CYP3A4 (supersome, BD Gentest #456202). As...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM143035(US8940739, E-65)
Affinity DataIC50:  2.11E+3nMpH: 7.4Assay Description:This assay was performed in a 200 l volume in 96-well microtiter plates using cDNA-expressed human hepatic CYP3A4 (supersome, BD Gentest #456202). As...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM142939(US8940739, D-14)
Affinity DataIC50:  2.13E+3nMpH: 7.4Assay Description:This assay was performed in a 200 l volume in 96-well microtiter plates using cDNA-expressed human hepatic CYP3A4 (supersome, BD Gentest #456202). As...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM143102(US8940739, G-5)
Affinity DataIC50:  2.16E+3nMpH: 7.4Assay Description:This assay was performed in a 200 l volume in 96-well microtiter plates using cDNA-expressed human hepatic CYP3A4 (supersome, BD Gentest #456202). As...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM143080(US8940739, F-48)
Affinity DataIC50:  2.18E+3nMpH: 7.4Assay Description:This assay was performed in a 200 l volume in 96-well microtiter plates using cDNA-expressed human hepatic CYP3A4 (supersome, BD Gentest #456202). As...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM142964(US8940739, D-59)
Affinity DataIC50:  2.19E+3nMpH: 7.4Assay Description:This assay was performed in a 200 l volume in 96-well microtiter plates using cDNA-expressed human hepatic CYP3A4 (supersome, BD Gentest #456202). As...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM142982(US8940739, D-96)
Affinity DataIC50:  2.19E+3nMpH: 7.4Assay Description:This assay was performed in a 200 l volume in 96-well microtiter plates using cDNA-expressed human hepatic CYP3A4 (supersome, BD Gentest #456202). As...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM261489(US10011568, Ex. No. 12 | US9708266, 12)
Affinity DataIC50:  2.20E+3nMpH: 7.4 T: 2°CAssay Description:A dimethyl sulfoxide (DMSO) solution of a test compound with a concentration 1000 times higher than the evaluation concentration was prepared, and a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM143019(US8940739, E-47)
Affinity DataIC50:  2.20E+3nMpH: 7.4Assay Description:This assay was performed in a 200 l volume in 96-well microtiter plates using cDNA-expressed human hepatic CYP3A4 (supersome, BD Gentest #456202). As...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM143135(US8940739, G-38)
Affinity DataIC50:  2.21E+3nMpH: 7.4Assay Description:This assay was performed in a 200 l volume in 96-well microtiter plates using cDNA-expressed human hepatic CYP3A4 (supersome, BD Gentest #456202). As...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM143031(US8940739, E-61)
Affinity DataIC50:  2.23E+3nMpH: 7.4Assay Description:This assay was performed in a 200 l volume in 96-well microtiter plates using cDNA-expressed human hepatic CYP3A4 (supersome, BD Gentest #456202). As...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM142993(US8940739, E-7)
Affinity DataIC50:  2.24E+3nMpH: 7.4Assay Description:This assay was performed in a 200 l volume in 96-well microtiter plates using cDNA-expressed human hepatic CYP3A4 (supersome, BD Gentest #456202). As...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM142960(US8940739, D-55)
Affinity DataIC50:  2.26E+3nMpH: 7.4Assay Description:This assay was performed in a 200 l volume in 96-well microtiter plates using cDNA-expressed human hepatic CYP3A4 (supersome, BD Gentest #456202). As...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM143125(US8940739, G-28)
Affinity DataIC50:  2.32E+3nMpH: 7.4Assay Description:This assay was performed in a 200 l volume in 96-well microtiter plates using cDNA-expressed human hepatic CYP3A4 (supersome, BD Gentest #456202). As...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM143082(US8940739, F-53)
Affinity DataIC50:  2.33E+3nMpH: 7.4Assay Description:This assay was performed in a 200 l volume in 96-well microtiter plates using cDNA-expressed human hepatic CYP3A4 (supersome, BD Gentest #456202). As...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM143152(US8940739, G-55)
Affinity DataIC50:  2.37E+3nMpH: 7.4Assay Description:This assay was performed in a 200 l volume in 96-well microtiter plates using cDNA-expressed human hepatic CYP3A4 (supersome, BD Gentest #456202). As...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM143119(US8940739, G-22)
Affinity DataIC50:  2.38E+3nMpH: 7.4Assay Description:This assay was performed in a 200 l volume in 96-well microtiter plates using cDNA-expressed human hepatic CYP3A4 (supersome, BD Gentest #456202). As...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM143088(US8940739, F-59)
Affinity DataIC50:  2.39E+3nMpH: 7.4Assay Description:This assay was performed in a 200 l volume in 96-well microtiter plates using cDNA-expressed human hepatic CYP3A4 (supersome, BD Gentest #456202). As...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM142943(US8940739, D-18)
Affinity DataIC50:  2.42E+3nMpH: 7.4Assay Description:This assay was performed in a 200 l volume in 96-well microtiter plates using cDNA-expressed human hepatic CYP3A4 (supersome, BD Gentest #456202). As...More data for this Ligand-Target Pair
In DepthDetails US Patent
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