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Report error Found 31 of ph data with Target = 'Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial'
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 101762BDBM101762(US8530490, 22)
Affinity DataIC50: 30nMpH: 7.4 T: 2°CAssay Description:The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details
US Patent

TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 101764BDBM101764(US8530490, 24)
Affinity DataIC50: 40nMpH: 7.4 T: 2°CAssay Description:The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details
US Patent

TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 101763BDBM101763(CHEMBL2057909 | US8530490, 23)
Affinity DataIC50: 50nMpH: 7.4 T: 2°CAssay Description:The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details
US Patent

TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 101745BDBM101745(US8530490, 5)
Affinity DataIC50: 60nMpH: 7.4 T: 2°CAssay Description:The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 101748BDBM101748(CHEMBL2057911 | US8530490, 8)
Affinity DataIC50: 90nMpH: 7.4 T: 2°CAssay Description:The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details
US Patent

TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 101808BDBM101808(US8530490, 68)
Affinity DataIC50: 110nMpH: 7.4 T: 2°CAssay Description:The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details
US Patent

TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 101897BDBM101897(US8530490, 167)
Affinity DataIC50: 130nMpH: 7.4 T: 2°CAssay Description:The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details
US Patent

TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 101801BDBM101801(US8530490, 61)
Affinity DataIC50: 140nMpH: 7.4 T: 2°CAssay Description:The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details
US Patent

TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 101787BDBM101787(US8530490, 47)
Affinity DataIC50: 210nMpH: 7.4 T: 2°CAssay Description:The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details
US Patent

TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 101793BDBM101793(US8530490, 53)
Affinity DataIC50: 230nMpH: 7.4 T: 2°CAssay Description:The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details
US Patent

TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 101794BDBM101794(US8530490, 54)
Affinity DataIC50: 230nMpH: 7.4 T: 2°CAssay Description:The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details
US Patent

TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 101761BDBM101761(US8530490, 21)
Affinity DataIC50: 270nMpH: 7.4 T: 2°CAssay Description:The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details
US Patent

TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 101798BDBM101798(US8530490, 58)
Affinity DataIC50: 310nMpH: 7.4 T: 2°CAssay Description:The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details
US Patent

TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 101909BDBM101909(US8530490, 1)
Affinity DataIC50: 330nMpH: 7.4 T: 2°CAssay Description:The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details
US Patent

TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 5118BDBM5118(US8530490, 6 | US8530490, 49 | US8530490, 397)
Affinity DataIC50: 460nMpH: 7.4 T: 2°CAssay Description:The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details
US Patent

TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 101751BDBM101751(US8530490, 11)
Affinity DataIC50: 490nMpH: 7.4 T: 2°CAssay Description:The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details
US Patent

TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 139105BDBM139105(US8883759, 19)
Affinity DataIC50: 610nMpH: 7.4 T: 2°CAssay Description:The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details
US Patent

TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 101747BDBM101747(US8530490, 7)
Affinity DataIC50: 640nMpH: 7.4 T: 2°CAssay Description:The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details
US Patent

TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 101799BDBM101799(US8530490, 59)
Affinity DataIC50: 720nMpH: 7.4 T: 2°CAssay Description:The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details
US Patent

TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 101809BDBM101809(US8530490, 69)
Affinity DataIC50: 740nMpH: 7.4 T: 2°CAssay Description:The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details
US Patent

TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 50173548BDBM50173548(dUTPase inhibitor, 1 | CHEMBL373232 | Phosphoric a...)
Affinity DataKi:  1.35E+5nM ΔG°:  -22.1kJ/molepH: 8.0 T: 2°CAssay Description:Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2012
Entry Details Article
PubMed
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 50173546BDBM50173546(dUTPase inhibitor, 2 | CHEMBL369937 | 1-(5-Tritylo...)
Affinity DataKi:  1.56E+5nM ΔG°:  -21.7kJ/molepH: 8.0 T: 2°CAssay Description:Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2012
Entry Details Article
PubMed
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 91592BDBM91592(dUTPase inhibitor, 3)
Affinity DataKi:  2.98E+5nM ΔG°:  -20.1kJ/molepH: 8.0 T: 2°CAssay Description:Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2012
Entry Details Article
PubMed
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 50173554BDBM50173554(CHEMBL194480 | dUTPase inhibitor, 4 | Hexadecanoic...)
Affinity DataKi:  3.50E+5nM ΔG°:  -19.7kJ/molepH: 8.0 T: 2°CAssay Description:Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2012
Entry Details Article
PubMed
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 50173530BDBM50173530(CHEMBL370768 | dUTPase inhibitor, 9 | 1-[5-(tert-B...)
Affinity DataKi:  8.05E+5nM ΔG°:  -17.7kJ/molepH: 8.0 T: 2°CAssay Description:Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2012
Entry Details Article
PubMed
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 50173532BDBM50173532(dUTPase inhibitor, 7 | CHEMBL370908 | 1-[5-(tert-B...)
Affinity DataKi:  8.07E+5nM ΔG°:  -17.7kJ/molepH: 8.0 T: 2°CAssay Description:Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2012
Entry Details Article
PubMed
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 50173531BDBM50173531(CHEMBL197290 | dUTPase inhibitor, 8 | 1-(4-Hydroxy...)
Affinity DataKi:  9.08E+5nM ΔG°:  -17.4kJ/molepH: 8.0 T: 2°CAssay Description:Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2012
Entry Details Article
PubMed
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 50173567BDBM50173567(dUTPase inhibitor, 6 | CHEMBL195997 | 1-[5-(tert-B...)
Affinity DataKi: >1.00E+6nM ΔG°: >-17.1kJ/molepH: 8.0 T: 2°CAssay Description:Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2012
Entry Details Article
PubMed
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 50173540BDBM50173540(dUTPase inhibitor, 5 | CHEMBL371690 | 1-[5-(tert-B...)
Affinity DataKi: >1.00E+6nM ΔG°: >-17.1kJ/molepH: 8.0 T: 2°CAssay Description:Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2012
Entry Details Article
PubMed
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 50173576BDBM50173576(CHEMBL364710 | dUTPase inhibitor, 11 | 1-[5-(Benzy...)
Affinity DataKi:  1.00E+6nM ΔG°:  -17.1kJ/molepH: 8.0 T: 2°CAssay Description:Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2012
Entry Details Article
PubMed
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 50173566BDBM50173566(CHEMBL199038 | dUTPase inhibitor, 10 | 1-(4-Hydrox...)
Affinity DataKi:  1.00E+6nM ΔG°:  -17.1kJ/molepH: 8.0 T: 2°CAssay Description:Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2012
Entry Details Article
PubMed