Compile Data Set for Download or QSAR
maximum 50k data
Found 71 of ph data with Target = 'Disintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q]'
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26526((2R)-N-hydroxy-2-[(3S)-3-methyl-3-{4-[(2-methylqui...)
Affinity DataKi:  0.0600nM ΔG°:  -57.8kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26524((1R,2S)-1-({3-fluoro-4-[(2-phenylquinolin-4-yl)met...)
Affinity DataKi:  0.140nM ΔG°:  -55.7kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26525((1S,2R)-1-N-hydroxy-2-({4-[(2-phenylquinolin-4-yl)...)
Affinity DataKi:  0.180nM ΔG°:  -55.1kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26555(2-{[4-(but-2-yn-1-ylamino)benzene]sulfonyl}ethane-...)
Affinity DataKi:  2nM ΔG°:  -49.2kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM23487((1S,2R)-1-N-hydroxy-2-({4-[(2-methylquinolin-4-yl)...)
Affinity DataKi:  3nM ΔG°:  -48.2kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26556(3-{[4-(but-2-yn-1-ylamino)benzene]sulfonyl}propane...)
Affinity DataKi:  4.5nM ΔG°:  -47.2kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26549((3R)-1-{[4-(but-2-yn-1-ylamino)benzene]sulfonyl}py...)
Affinity DataKi:  5nM ΔG°:  -46.9kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM23477((1R,2R)-2-N-hydroxy-1-{3-[(2-methylquinolin-4-yl)m...)
Affinity DataKi:  5nM ΔG°:  -46.9kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26527((1S,3R)-6-{3-fluoro-4-[(2-phenylquinolin-4-yl)meth...)
Affinity DataKi:  6.70nM ΔG°:  -46.2kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26553(2-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}ethane-1-...)
Affinity DataKi:  8nM ΔG°:  -45.7kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM23458(hydroxamate deriv., 48 | propan-2-yl (1R,2R)-2-(hy...)
Affinity DataKi:  8nM ΔG°:  -45.7kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM23482((1R,2R)-1-N-cyclohexyl-2-N-hydroxy-1-{3-[(2-methyl...)
Affinity DataKi:  9nM ΔG°:  -45.5kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26550(2-{[4-(but-2-yn-1-yloxy)benzene](methyl)sulfonamid...)
Affinity DataKi:  10nM ΔG°:  -45.2kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26550(2-{[4-(but-2-yn-1-yloxy)benzene](methyl)sulfonamid...)
Affinity DataKi:  10nM ΔG°:  -45.2kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26554(3-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}propane-1...)
Affinity DataKi:  10nM ΔG°:  -45.2kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM23456(hydroxamate deriv., 44 | methyl (1R,2R)-1-{3-[(3,4...)
Affinity DataKi:  11nM ΔG°:  -45.0kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26548(1-{[4-(but-2-yn-1-ylamino)benzene]sulfonyl}azetidi...)
Affinity DataKi:  11nM ΔG°:  -45.0kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM23480((1R,2R)-2-N-hydroxy-1-{3-[(2-methylquinolin-4-yl)m...)
Affinity DataKi:  11nM ΔG°:  -45.0kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM23454(CHEMBL270558 | hydroxamate deriv., 26 | methyl (1R...)
Affinity DataKi:  12nM ΔG°:  -44.8kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26542(1-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}azetidine...)
Affinity DataKi:  13nM ΔG°:  -44.6kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM23476(ethyl (1R,2R)-2-(hydroxycarbamoyl)-1-{3-[(2-methyl...)
Affinity DataKi:  16nM ΔG°:  -44.0kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26559(3-{[4-(but-2-yn-1-ylamino)benzene]sulfonyl}cyclohe...)
Affinity DataKi:  17nM ΔG°:  -43.9kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM23464(hydroxamate deriv., 56 | methyl (1R,2R)-2-(hydroxy...)
Affinity DataKi:  18nM ΔG°:  -43.8kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26552(4-(but-2-yn-1-yloxy)-N-methyl-N-[(2S)-2-sulfanylpr...)
Affinity DataKi:  27nM ΔG°:  -42.8kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26543((3R)-1-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}pyrr...)
Affinity DataKi:  28nM ΔG°:  -42.7kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26543((3R)-1-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}pyrr...)
Affinity DataKi:  28nM ΔG°:  -42.7kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26528((1S,3R)-N-hydroxy-4-oxo-6-{4-[(2-phenylquinolin-4-...)
Affinity DataKi:  30nM ΔG°:  -42.5kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26558(3-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}cyclohexa...)
Affinity DataKi:  30nM ΔG°:  -42.5kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26530((1S,3R)-N-hydroxy-6-{4-[(2-methylquinolin-4-yl)met...)
Affinity DataKi:  32nM ΔG°:  -42.3kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26529((1S,3R)-N-hydroxy-4-oxo-6-(4-{[2-(pyridin-3-yl)qui...)
Affinity DataKi:  32nM ΔG°:  -42.3kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26544((3S)-1-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}pyrr...)
Affinity DataKi:  33nM ΔG°:  -42.3kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26531((1S,3R)-N-hydroxy-4-oxo-6-(4-{[2-(pyridin-4-yl)qui...)
Affinity DataKi:  33nM ΔG°:  -42.3kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26534((1S,3R)-6-{3-fluoro-4-[(2-phenylquinolin-4-yl)meth...)
Affinity DataKi:  40nM ΔG°:  -41.8kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM23465(hydroxamate deriv., 57 | methyl (1R,2R)-1-{3-[(4-c...)
Affinity DataKi:  50nM ΔG°:  -41.3kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM23470(hydroxamate deriv., 62 | methyl (1R,2R)-1-[3-(2-{3...)
Affinity DataKi:  50nM ΔG°:  -41.3kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26557(3-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}cyclopent...)
Affinity DataKi:  50nM ΔG°:  -41.3kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26532((1S,3R)-N-hydroxy-4-oxo-6-(4-{[2-(trifluoromethyl)...)
Affinity DataKi:  53nM ΔG°:  -41.1kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26545(1-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}piperidin...)
Affinity DataKi:  55nM ΔG°:  -41.0kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26551(4-(but-2-yn-1-yloxy)-N-methyl-N-(2-sulfanylethyl)b...)
Affinity DataKi:  56nM ΔG°:  -41.0kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM23469(hydroxamate deriv., 61 | methyl (1R,2R)-2-(hydroxy...)
Affinity DataKi:  60nM ΔG°:  -40.8kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM23471(hydroxamate deriv., 63 | methyl (1R,2R)-2-(hydroxy...)
Affinity DataKi:  70nM ΔG°:  -40.4kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM23463(hydroxamate deriv., 55 | methyl (1R,2R)-2-(hydroxy...)
Affinity DataKi:  70nM ΔG°:  -40.4kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM23466(hydroxamate deriv., 58 | methyl (1R,2R)-1-{3-[(3-f...)
Affinity DataKi:  80nM ΔG°:  -40.1kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26535((1S,3R)-6-{3-fluoro-4-[(2-phenylquinolin-4-yl)meth...)
Affinity DataKi:  94nM ΔG°:  -39.7kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM23478((1R,2R)-2-N-hydroxy-1-N-methyl-1-{3-[(2-methylquin...)
Affinity DataKi:  100nM ΔG°:  -39.6kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM23462(hydroxamate deriv., 54 | methyl (1R,2R)-2-(hydroxy...)
Affinity DataKi:  110nM ΔG°:  -39.3kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26533((1S,3R)-6-{3-fluoro-4-[(2-phenylquinolin-4-yl)meth...)
Affinity DataKi:  137nM ΔG°:  -38.8kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM23473(hydroxamate deriv., 65 | methyl (1R,2R)-2-(hydroxy...)
Affinity DataKi:  140nM ΔG°:  -38.7kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM23459((1R,2R)-1-N-benzyl-2-N-hydroxy-1-{3-[(2-methylquin...)
Affinity DataKi:  140nM ΔG°:  -38.7kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26536((1S,3R)-4-oxo-6-{4-[(2-phenylquinolin-4-yl)methoxy...)
Affinity DataKi:  143nM ΔG°:  -38.7kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
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