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Found 101 of ph data with Target = 'Dual specificity mitogen-activated protein kinase kinase 1/Mitogen-activated protein kinase 1/Serine/threonine-protein kinase B-raf'
LigandPNGBDBM200424(US10011599, Example 51 | US9227969, 51 | US9629836...)
Affinity DataIC50:  1nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM200427(US10011599, Example 54 | US9227969, 54 | US9629836...)
Affinity DataIC50:  1.5nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM200420(US10011599, Example 47 | US9227969, 47 | US9629836...)
Affinity DataIC50:  1.70nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM200417(US9227969, 44 | US9629836, 44)
Affinity DataIC50:  2nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM200436(US10011599, Example 65 | US9227969, 65 | US9629836...)
Affinity DataIC50:  2.40nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM200461(US10011599, Example 90 | US9227969, 90 | US9629836...)
Affinity DataIC50:  2.60nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM200460(US10011599, Example 89 | US9227969, 89 | US9629836...)
Affinity DataIC50:  2.60nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM200465(US10011599, Example 94 | US9227969, 94 | US9629836...)
Affinity DataIC50:  2.70nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM200409(US10011599, Example 37 | US9227969, 37 | US9629836...)
Affinity DataIC50:  2.70nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM200403(US10011599, Example 31 | US9227969, 31 | US9629836...)
Affinity DataIC50:  3nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM200430(US9227969, 58)
Affinity DataIC50:  3nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM200444(US10011599, Example 73 | US9227969, 73 | US9629836...)
Affinity DataIC50:  3.60nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM200400(US10011599, Example 28 | US9227969, 28 | US9629836...)
Affinity DataIC50:  3.70nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
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LigandPNGBDBM200433(US9227969, 62)
Affinity DataIC50:  3.70nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
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LigandPNGBDBM200446(US10011599, Example 75 | US9227969, 75 | US9629836...)
Affinity DataIC50:  3.80nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM200398(US10011599, Example 26 | US9227969, 26 | US9629836...)
Affinity DataIC50:  4.30nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM200441(US10011599, Example 70 | US9227969, 70 | US9629836...)
Affinity DataIC50:  4.30nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM200453(US10011599, Example 82 | US9227969, 82)
Affinity DataIC50:  4.5nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM200410(US10011599, Example 38 | US9227969, 38 | US9629836...)
Affinity DataIC50:  4.60nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
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LigandPNGBDBM200439(US10011599, Example 68 | US9227969, 68 | US9629836...)
Affinity DataIC50:  4.70nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
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LigandPNGBDBM200372(US10011599, Example 1A | US9227969, 1A | US9629836...)
Affinity DataIC50:  5nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM200435(US10011599, Example 64 | US9227969, 64 | US9629836...)
Affinity DataIC50:  5.30nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM200459(US9227969, 88)
Affinity DataIC50:  5.70nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM200426(US10011599, Example 87 | US9227969, 53 | US9227969...)
Affinity DataIC50:  6.20nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM200426(US10011599, Example 87 | US9227969, 53 | US9227969...)
Affinity DataIC50:  6.20nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM200452(US10011599, Example 81 | US9227969, 81)
Affinity DataIC50:  7nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM200386(US10011599, Example 14 | US9227969, 14 | US9629836...)
Affinity DataIC50:  7.10nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM200466(US10011599, Example 95 | US9227969, 95 | US9629836...)
Affinity DataIC50:  7.30nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM200434(US10011599, Example 63 | US9227969, 63 | US9629836...)
Affinity DataIC50:  8.5nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM200470(US10011599, Example 99 | US9227969, 99 | US9629836...)
Affinity DataIC50:  8.5nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM200425(US10011599, Example 52 | US9227969, 52)
Affinity DataIC50:  9nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM200450(US10011599, Example 79 | US9227969, 79 | US9629836...)
Affinity DataIC50:  9.20nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM200445(US10011599, Example 74 | US9227969, 74 | US9629836...)
Affinity DataIC50:  10nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM200437(US10011599, Example 66 | US9227969, 66 | US9629836...)
Affinity DataIC50:  10nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM200419(US10011599, Example 46 | US9227969, 46 | US9629836...)
Affinity DataIC50:  10nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM200468(US10011599, Example 97 | US9227969, 97 | US9629836...)
Affinity DataIC50:  11nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM200457(US10011599, Example 86 | US9227969, 86 | US9629836...)
Affinity DataIC50:  11nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
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LigandPNGBDBM200456(US10011599, Example 85 | US9227969, 85 | US9629836...)
Affinity DataIC50:  11nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM200421(US10011599, Example 48 | US9227969, 48 | US9629836...)
Affinity DataIC50:  11nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM200402(US10011599, Example 30 | US9227969, 30 | US9629836...)
Affinity DataIC50:  11nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM200423(US10011599, Example 50 | US9227969, 50)
Affinity DataIC50:  12nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM200451(US10011599, Example 80 | US9227969, 80 | US9629836...)
Affinity DataIC50:  13nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM200390(US10011599, Example 18 | US9227969, 18 | US9629836...)
Affinity DataIC50:  13nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM200380(US10011599, Example 8 | US9227969, 8 | US9629836, ...)
Affinity DataIC50:  15nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM200387(US10011599, Example 15 | US9227969, 15 | US9629836...)
Affinity DataIC50:  16nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM200462(US10011599, Example 91 | US9227969, 91 | US9629836...)
Affinity DataIC50:  18nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
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LigandPNGBDBM200431(US10011599, Example 59 | US9227969, 59 | US9629836...)
Affinity DataIC50:  18nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM200407(US10011599, Example 35 | US9227969, 35 | US9629836...)
Affinity DataIC50:  19nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM200401(US10011599, Example 29 | US9227969, 29 | US9629836...)
Affinity DataIC50:  19nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
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LigandPNGBDBM200471(US9227969, 57)
Affinity DataIC50:  19nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
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