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Found 25 of ph data with Target = 'Epidermal growth factor receptor [T790M]'
TargetEpidermal growth factor receptor [T790M](Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228125((e)-n-(4-((3,4-dichloro-2-fluorophenyl)amino)-7-et...)
Affinity DataIC50:  4nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
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TargetEpidermal growth factor receptor [T790M](Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228117((e)-n-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)...)
Affinity DataIC50:  4.20nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
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TargetEpidermal growth factor receptor [T790M](Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228126((e)-n-(4-((3,4-dichloro-2-fluorophenyl)amino)-7-(2...)
Affinity DataIC50:  5nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
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TargetEpidermal growth factor receptor [T790M](Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228118((e)-n-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)...)
Affinity DataIC50:  5.90nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
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TargetEpidermal growth factor receptor [T790M](Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228109((e)-n-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxy...)
Affinity DataIC50:  6.20nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
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TargetEpidermal growth factor receptor [T790M](Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228124((e)-n-(4-((3,4-dichloro-2-fluorophenyl)amino)-7-me...)
Affinity DataIC50:  6.40nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
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TargetEpidermal growth factor receptor [T790M](Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228110((e)-n-(4-((3-chloro-4-fluorophenyl)amino)-7-(((s)-...)
Affinity DataIC50:  6.80nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
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TargetEpidermal growth factor receptor [T790M](Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228127((e)-n-(4-((3,4-dichloro-2-fluorophenyl)amino)-7-((...)
Affinity DataIC50:  7nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
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TargetEpidermal growth factor receptor [T790M](Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228107( (E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-metho...)
Affinity DataIC50:  8.30nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
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TargetEpidermal growth factor receptor [T790M](Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228116((e)-n-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)...)
Affinity DataIC50:  8.5nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
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TargetEpidermal growth factor receptor [T790M](Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228111((e)-n-(4-((3-chloro-4-fluorophenyl)amino)-7-(2-met...)
Affinity DataIC50:  8.70nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
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TargetEpidermal growth factor receptor [T790M](Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228113((e)-n-(4-((3-chloro-4-fluorophenyl)amino)-7-(metho...)
Affinity DataIC50:  12.5nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
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TargetEpidermal growth factor receptor [T790M](Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228121((e)-n-(7-ethoxy-4-((1-(3-fluorobenzyl)-1h-indazol-...)
Affinity DataIC50:  14.5nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
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TargetEpidermal growth factor receptor [T790M](Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228108((e)-n-(4-((3-chloro-4-fluorophenyl)amino)-7-methox...)
Affinity DataIC50:  16nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
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TargetEpidermal growth factor receptor [T790M](Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228128((e)-n-(4-((3-chloro-2,4-difluorophenyl)amino)-7-me...)
Affinity DataIC50:  20nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
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TargetEpidermal growth factor receptor [T790M](Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228112((e)-n-(4-((3-chloro-4-fluorophenyl)amino)-7-(2,2,2...)
Affinity DataIC50:  22.6nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
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TargetEpidermal growth factor receptor [T790M](Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228120((e)-n-(4-((1-(3-fluorobenzyl)-1h-indazol-5-yl)amin...)
Affinity DataIC50:  22.9nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
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TargetEpidermal growth factor receptor [T790M](Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228115((e)-n-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)...)
Affinity DataIC50:  47.3nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
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TargetEpidermal growth factor receptor [T790M](Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228122((e)-n-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)...)
Affinity DataIC50:  87.3nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
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TargetEpidermal growth factor receptor [T790M](Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228119((e)-n-(4-((1-(3-fluorobenzyl)-1h-indazol-5-yl)amin...)
Affinity DataIC50:  89.3nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
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TargetEpidermal growth factor receptor [T790M](Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228123((e)-n-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)...)
Affinity DataIC50:  133nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
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TargetEpidermal growth factor receptor [T790M](Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Affinity DataIC50:  280nMpH: 7.5 T: 2°CAssay Description:FlashPlates from Perkin Elmer (Boston, Mass., USA) with a 50 μl reaction volume are used. The reaction cocktail was pipetted in 4 steps in the fol...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [T790M](Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM228114((e)-n-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)...)
Affinity DataIC50:  317nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
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TargetEpidermal growth factor receptor [T790M](Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM50379214(CHEMBL2011291 | US9416123, 6)
Affinity DataIC50:  2.00E+3nMpH: 7.5 T: 2°CAssay Description:FlashPlates from Perkin Elmer (Boston, Mass., USA) with a 50 μl reaction volume are used. The reaction cocktail was pipetted in 4 steps in the fol...More data for this Ligand-Target Pair
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TargetEpidermal growth factor receptor [T790M](Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM50379214(CHEMBL2011291 | US9416123, 6)
Affinity DataIC50:  3.30E+3nMpH: 7.5 T: 2°CAssay Description:FlashPlates from Perkin Elmer (Boston, Mass., USA) with a 50 μl reaction volume are used. The reaction cocktail was pipetted in 4 steps in the fol...More data for this Ligand-Target Pair
In DepthDetails US Patent