Compile Data Set for Download or QSAR
maximum 50k data
Found 89 of ph data with Target = 'Inhibitor of nuclear factor kappa-B kinase subunit alpha'
LigandPNGBDBM27476(2-amino-5-(pyridin-4-yl)-3-(4-sulfamoylphenyl)benz...)
Affinity DataIC50:  79nMpH: 7.4 T: 2°CAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25920(N,12-dimethyl-11,14,17-triazatetracyclo[8.7.0.0^{3...)
Affinity DataIC50:  230nMpH: 8.0 T: 2°CAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25921(benzimidazoquinoxaline analogue, 7b | methyl[2-({1...)
Affinity DataIC50:  390nMpH: 8.0 T: 2°CAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM27467(2-amino-5-(4-chlorophenyl)-3-(4-sulfamoylphenyl)be...)
Affinity DataIC50:  398nMpH: 7.4 T: 2°CAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25942((3-{8-[(2-aminoethyl)amino]-12-methyl-3-thia-1,7,1...)
Affinity DataIC50:  450nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM27466(2-amino-5-(4-fluorophenyl)-3-(4-sulfamoylphenyl)be...)
Affinity DataIC50:  501nMpH: 7.4 T: 2°CAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25924(N,12-dimethyl-14,15,17-triazatetracyclo[8.7.0.0^{3...)
Affinity DataIC50:  670nMpH: 8.0 T: 2°CAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25939(N-(2-aminoethyl)-4-(3-methoxyphenyl)-12-methyl-3-t...)
Affinity DataIC50:  690nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25922(2-({12-methyl-11,14,17-triazatetracyclo[8.7.0.0^{3...)
Affinity DataIC50:  870nMpH: 8.0 T: 2°CAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25944(2-(3-{8-[(2-aminoethyl)amino]-12-methyl-3-thia-1,7...)
Affinity DataIC50:  910nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25929(N-(2-aminoethyl)-12-methyl-4-phenyl-3-thia-1,7,10-...)
Affinity DataIC50:  910nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25931(N-(2-aminoethyl)-4-(furan-3-yl)-12-methyl-3-thia-1...)
Affinity DataIC50:  940nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25925(N,12-dimethyl-12,14,17-triazatetracyclo[8.7.0.0^{3...)
Affinity DataIC50:  990nMpH: 8.0 T: 2°CAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM27471(2-amino-5-phenyl-3-(4-sulfamoylphenyl)benzamide | ...)
Affinity DataIC50:  1.00E+3nMpH: 7.4 T: 2°CAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
LigandPNGBDBM25946(N,12-dimethyl-4-phenyl-3-thia-1,7,10-triazatricycl...)
Affinity DataIC50:  1.09E+3nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25930(N-(2-aminoethyl)-12-methyl-4-(1,3-thiazol-2-yl)-3-...)
Affinity DataIC50:  1.11E+3nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25949(dimethyl[2-({12-methyl-4-phenyl-3-thia-1,7,10-tria...)
Affinity DataIC50:  1.17E+3nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25935(N-(2-aminoethyl)-12-methyl-4-(pyridin-2-yl)-3-thia...)
Affinity DataIC50:  1.24E+3nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25933(N-(2-aminoethyl)-12-methyl-4-(1H-pyrrol-2-yl)-3-th...)
Affinity DataIC50:  1.26E+3nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25934(N-(2-aminoethyl)-12-methyl-4-(1H-pyrazol-4-yl)-3-t...)
Affinity DataIC50:  1.45E+3nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25926(N-(2-aminoethyl)-12-methyl-12,14,17-triazatetracyc...)
Affinity DataIC50:  1.60E+3nMpH: 8.0 T: 2°CAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25923(12-methyl-N-[2-(piperidin-1-yl)ethyl]-11,14,17-tri...)
Affinity DataIC50:  1.70E+3nMpH: 8.0 T: 2°CAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25948(N-ethyl-12-methyl-4-phenyl-3-thia-1,7,10-triazatri...)
Affinity DataIC50:  1.99E+3nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM27484(5-(4-chlorophenyl)-2-hydroxy-3-(4-sulfamoylphenyl)...)
Affinity DataIC50:  2.00E+3nMpH: 7.4 T: 2°CAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM27477(2-amino-5-(4-methanesulfonylphenyl)-3-(4-sulfamoyl...)
Affinity DataIC50:  2.00E+3nMpH: 7.4 T: 2°CAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM27485(2-hydroxy-3-(4-methanesulfonamidophenyl)-5-phenylb...)
Affinity DataIC50:  2.00E+3nMpH: 7.4 T: 2°CAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM25943((4-{8-[(2-aminoethyl)amino]-12-methyl-3-thia-1,7,1...)
Affinity DataIC50:  2.33E+3nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM27465(2-amino-5-(4-fluorophenyl)-3-[4-(pyrrolidine-1-sul...)
Affinity DataIC50:  2.51E+3nMpH: 7.4 T: 2°CAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM29411(7-alkoxyisoquinoline, 21)
Affinity DataIC50:  2.51E+3nMpH: 7.4 T: 2°CAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25936(N-(2-aminoethyl)-12-methyl-4-(pyridin-3-yl)-3-thia...)
Affinity DataIC50:  2.57E+3nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25940(N-(2-aminoethyl)-4-(4-methoxyphenyl)-12-methyl-3-t...)
Affinity DataIC50:  2.80E+3nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25937(N-(2-aminoethyl)-12-methyl-4-(pyridin-4-yl)-3-thia...)
Affinity DataIC50:  2.93E+3nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25953(12-methyl-4-phenyl-N-[2-(piperidin-1-yl)ethyl]-3-t...)
Affinity DataIC50:  3.13E+3nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM29421(7-alkoxyisoquinoline, 31)
Affinity DataIC50:  3.16E+3nMpH: 7.4 T: 2°CAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM27475(2-amino-3-phenyl-5-(pyridin-4-yl)benzamide | Amino...)
Affinity DataIC50:  3.16E+3nMpH: 7.4 T: 2°CAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25954(2-({12-methyl-4-phenyl-3-thia-1,7,10-triazatricycl...)
Affinity DataIC50:  3.48E+3nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25932(N-(2-aminoethyl)-4-(1H-imidazol-4-yl)-12-methyl-3-...)
Affinity DataIC50:  3.86E+3nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM29408(7-alkoxyisoquinoline, 18)
Affinity DataIC50:  3.98E+3nMpH: 7.4 T: 2°CAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM29420(7-alkoxyisoquinoline, 30)
Affinity DataIC50:  3.98E+3nMpH: 7.4 T: 2°CAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25919(BMS-345541 | BMS345541 | CHEMBL471496 | N-(2-amino...)
Affinity DataIC50:  4.00E+3nMpH: 8.0 T: 2°CAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25941((2-{8-[(2-aminoethyl)amino]-12-methyl-3-thia-1,7,1...)
Affinity DataIC50:  4.40E+3nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM27478(2-amino-5-(4-methanesulfonylphenyl)-3-[4-(pyrrolid...)
Affinity DataIC50:  5.01E+3nMpH: 7.4 T: 2°CAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM27486(3-[4-(dimethylsulfamoyl)phenyl]-2-hydroxy-5-(pyrid...)
Affinity DataIC50:  5.01E+3nMpH: 7.4 T: 2°CAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM29423(7-alkoxyisoquinoline, 33)
Affinity DataIC50:  5.01E+3nMpH: 7.4 T: 2°CAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM27464(2-amino-5-(4-fluorophenyl)-3-(pyridin-4-yl)benzami...)
Affinity DataIC50:  5.01E+3nMpH: 7.4 T: 2°CAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM29410(7-alkoxyisoquinoline, 20)
Affinity DataIC50:  6.31E+3nMpH: 7.4 T: 2°CAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM27468(2-amino-5-(4-chlorophenyl)-3-(4-methanesulfonamido...)
Affinity DataIC50:  6.31E+3nMpH: 7.4 T: 2°CAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25947(12-methyl-4-phenyl-3-thia-1,7,10-triazatricyclo[7....)
Affinity DataIC50:  6.50E+3nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25952(N-[2-({12-methyl-4-phenyl-3-thia-1,7,10-triazatric...)
Affinity DataIC50:  7.03E+3nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM29407(7-alkoxyisoquinoline, 17)
Affinity DataIC50:  7.94E+3nMpH: 7.4 T: 2°CAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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