Compile Data Set for Download or QSAR
maximum 50k data
Found 158 of ph data with Target = 'Lethal factor'
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM8525(4-{[(1S,2R,4S,5R)-2,4-bis(carbamimidamidomethyl)-5...)
Affinity DataKi:  65nM ΔG°:  -40.6kJ/molepH: 7.4 T: 2°CAssay Description:The enzymatic reaction started by the addition fluorogenic peptide substrate, MAPKKide to the buffer containing LF and inhibitor compound. Cleavage o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM19((2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-{[(2R,3...)
Affinity DataKi:  500nM ΔG°:  -35.6kJ/molepH: 7.4 T: 2°CAssay Description:The enzymatic reaction started by the addition fluorogenic peptide substrate, MAPKKide to the buffer containing LF and inhibitor compound. Cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM8524((1R,2S,4R,5S)-2,4-bis(carbamimidamidomethyl)-5-(2,...)
Affinity DataKi:  500nM ΔG°:  -35.6kJ/molepH: 7.4 T: 2°CAssay Description:The enzymatic reaction started by the addition fluorogenic peptide substrate, MAPKKide to the buffer containing LF and inhibitor compound. Cleavage o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM12008((1R,3S,4R,5R,6S)-4-{[(2R,3R,4R,5S,6R)-6-(aminometh...)
Affinity DataKi:  500nM ΔG°:  -35.6kJ/molepH: 7.4 T: 2°CAssay Description:The enzymatic reaction started by the addition fluorogenic peptide substrate, MAPKKide to the buffer containing LF and inhibitor compound. Cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM8517(4-[(1S,2S,4S,5R)-2,4-bis(carbamimidamidomethyl)-5-...)
Affinity DataKi:  600nM ΔG°:  -35.2kJ/molepH: 7.4 T: 2°CAssay Description:The enzymatic reaction started by the addition fluorogenic peptide substrate, MAPKKide to the buffer containing LF and inhibitor compound. Cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM11997((1R,3S,4R,5R,6S)-4-{[(2R,3R,4R,5S,6R)-3-carbamimid...)
Affinity DataKi:  700nM ΔG°:  -34.8kJ/molepH: 7.4 T: 2°CAssay Description:The enzymatic reaction started by the addition fluorogenic peptide substrate, MAPKKide to the buffer containing LF and inhibitor compound. Cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM12005((2R,3R,4R,5S,6R)-2-{[(1R,2R,3S,4R,6S)-4-amino-6-ca...)
Affinity DataKi:  700nM ΔG°:  -34.8kJ/molepH: 7.4 T: 2°CAssay Description:The enzymatic reaction started by the addition fluorogenic peptide substrate, MAPKKide to the buffer containing LF and inhibitor compound. Cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM11976(5-chloro-2-(5-{[(4E)-3,8-dioxo-5,16-dithia-2,7-dia...)
Affinity DataKi:  800nM ΔG°:  -35.0kJ/mole IC50:  1.10E+3nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM11983(3-(4-chlorophenyl)-1-{4-[(5-ethyl-1,3,4-thiadiazol...)
Affinity DataKi:  900nM ΔG°:  -34.7kJ/mole IC50:  4.80E+3nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM11996(2-[4-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl]acetic ac...)
Affinity DataKi:  900nM ΔG°:  -34.7kJ/mole IC50:  7.60E+3nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, the concentrations of inhibitor that caused 50% inhibition of enzymati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM11989(2-chloro-5-[(4Z)-3-methyl-5-oxo-4-{[4-(propan-2-yl...)
Affinity DataKi:  900nM ΔG°:  -34.7kJ/mole IC50:  8.20E+3nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM11980((5Z)-5-[(2,4-dihydroxyphenyl)methylidene]-2-sulfan...)
Affinity DataKi:  1.10E+3nM ΔG°:  -34.2kJ/mole IC50:  3.70E+3nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM11985(4-(2,5-dimethyl-1H-pyrrol-1-yl)-2-hydroxybenzoic a...)
Affinity DataKi:  1.50E+3nM ΔG°:  -33.5kJ/mole IC50:  3.80E+3nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM12012((1R,3S,4R,5R,6S)-4-{[(2R,3R,4R,5R,6R)-3-carbamimid...)
Affinity DataKi:  1.50E+3nM ΔG°:  -32.9kJ/molepH: 7.4 T: 2°CAssay Description:The enzymatic reaction started by the addition fluorogenic peptide substrate, MAPKKide to the buffer containing LF and inhibitor compound. Cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM11977(5-bromo-2-(5-{[(4Z)-1-(3-carboxyphenyl)-5-oxo-3-(t...)
Affinity DataKi:  1.60E+3nM ΔG°:  -33.3kJ/mole IC50:  1.80E+3nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM11994(2-{[4-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl]sulfanyl...)
Affinity DataKi:  1.60E+3nM ΔG°:  -33.3kJ/mole IC50:  2.90E+3nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, the concentrations of inhibitor that caused 50% inhibition of enzymati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM11991(8-{N-[4-(2,3-dihydro-1,3-thiazol-2-ylsulfamoyl)phe...)
Affinity DataKi:  1.80E+3nM ΔG°:  -33.0kJ/mole IC50:  8.70E+3nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM11993(2-chloro-5-[(4Z)-4-{[5-(4-chlorophenyl)furan-2-yl]...)
Affinity DataKi:  2.10E+3nM ΔG°:  -32.6kJ/mole IC50:  1.00E+4nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM11979(5-[(3-carboxy-4-hydroxyphenyl)methyl]-2-hydroxyben...)
Affinity DataKi:  2.40E+3nM ΔG°:  -32.3kJ/mole IC50:  2.90E+3nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM11984(2-chloro-4-{5-[N-(3-cyano-4,5,6,7-tetrahydro-1-ben...)
Affinity DataKi:  2.40E+3nM ΔG°:  -32.3kJ/mole IC50:  5.20E+3nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM11981(2-chloro-5-{[(4Z)-4-{[4-(methylsulfanyl)phenyl]met...)
Affinity DataKi:  2.50E+3nM ΔG°:  -32.2kJ/mole IC50:  3.30E+3nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM11978((1E,6E)-4-(1,3-dithian-2-ylidene)-1,7-bis(furan-2-...)
Affinity DataKi:  2.70E+3nM ΔG°:  -32.0kJ/mole IC50:  3.20E+3nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM11982(2-{[(2-amino-2-carboxyethyl)sulfanyl]methyl}-5-phe...)
Affinity DataKi:  2.90E+3nM ΔG°:  -31.8kJ/mole IC50:  4.10E+3nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM11987(2-hydroxy-5-(5-{[(5Z)-2-imino-4-oxo-3-(1,3-thiazol...)
Affinity DataKi:  3.10E+3nM ΔG°:  -31.7kJ/mole IC50:  4.20E+3nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM12010((2R,3R,4R,5S,6R)-2-{[(1R,2R,3S,4R,6S)-6-amino-4-ca...)
Affinity DataKi:  3.10E+3nM ΔG°:  -31.1kJ/molepH: 7.4 T: 2°CAssay Description:The enzymatic reaction started by the addition fluorogenic peptide substrate, MAPKKide to the buffer containing LF and inhibitor compound. Cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM11986(3-[(5E)-5-[(3-bromo-4-methoxyphenyl)methylidene]-4...)
Affinity DataKi:  3.30E+3nM ΔG°:  -31.5kJ/mole IC50:  4.70E+3nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM8519(2-[(1S,2S,4S,5R)-2,4-bis(carbamimidamidomethyl)-5-...)
Affinity DataKi:  4.10E+3nM ΔG°:  -30.4kJ/molepH: 7.4 T: 2°CAssay Description:The enzymatic reaction started by the addition fluorogenic peptide substrate, MAPKKide to the buffer containing LF and inhibitor compound. Cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM11988((5Z)-5-(1,3-benzothiazol-2-ylimino)-1-(4-sulfophen...)
Affinity DataKi:  4.20E+3nM ΔG°:  -30.9kJ/mole IC50:  9.20E+3nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM11998((1R,2S,3R,4R,5S)-5-amino-4-{[(2R,3R,4R,5S,6R)-3-am...)
Affinity DataKi:  5.00E+3nM ΔG°:  -30.0kJ/molepH: 7.4 T: 2°CAssay Description:The enzymatic reaction started by the addition fluorogenic peptide substrate, MAPKKide to the buffer containing LF and inhibitor compound. Cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM11999((1S,2R,3R,4S,5R)-5-amino-2-{[(2R,3R,4R,5S,6R)-3-am...)
Affinity DataKi:  5.20E+3nM ΔG°:  -29.9kJ/molepH: 7.4 T: 2°CAssay Description:The enzymatic reaction started by the addition fluorogenic peptide substrate, MAPKKide to the buffer containing LF and inhibitor compound. Cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM12003((2R,3R,4R,5S,6R)-2-{[(1R,2R,3S,4R,6S)-6-amino-4-ca...)
Affinity DataKi:  5.30E+3nM ΔG°:  -29.8kJ/molepH: 7.4 T: 2°CAssay Description:The enzymatic reaction started by the addition fluorogenic peptide substrate, MAPKKide to the buffer containing LF and inhibitor compound. Cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM11990(4-(5-{[(3E)-5-cyano-2-hydroxy-4-methyl-6-oxo-3,6-d...)
Affinity DataKi:  5.40E+3nM ΔG°:  -30.3kJ/mole IC50:  1.08E+4nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM11995(2-chloro-5-(2,5-dimethyl-1H-pyrrol-1-yl)benzoic ac...)
Affinity DataKi:  5.60E+3nM ΔG°:  -30.2kJ/mole IC50:  6.80E+3nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, the concentrations of inhibitor that caused 50% inhibition of enzymati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM12002((1R,3S,4R,5R,6S)-4-{[(2R,3R,4R,5S,6R)-3-amino-6-(a...)
Affinity DataKi:  5.60E+3nM ΔG°:  -29.7kJ/molepH: 7.4 T: 2°CAssay Description:The enzymatic reaction started by the addition fluorogenic peptide substrate, MAPKKide to the buffer containing LF and inhibitor compound. Cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM8518(6-[(1S,2S,4S,5R)-2,4-bis(carbamimidamidomethyl)-5-...)
Affinity DataKi:  6.60E+3nM ΔG°:  -29.3kJ/molepH: 7.4 T: 2°CAssay Description:The enzymatic reaction started by the addition fluorogenic peptide substrate, MAPKKide to the buffer containing LF and inhibitor compound. Cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM11992(3-(5-{[(4Z)-1-(3-chlorophenyl)-3,5-dioxopyrazolidi...)
Affinity DataKi:  7.20E+3nM ΔG°:  -29.5kJ/mole IC50:  1.39E+4nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM12007((2R,3R,4R,5S,6R)-6-(carbamimidamidomethyl)-2-{[(1R...)
Affinity DataKi:  7.70E+3nM ΔG°:  -28.9kJ/molepH: 7.4 T: 2°CAssay Description:The enzymatic reaction started by the addition fluorogenic peptide substrate, MAPKKide to the buffer containing LF and inhibitor compound. Cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM12009((1R,3S,4R,5R,6S)-4-{[(2R,3R,4R,5S,6R)-3-amino-6-(c...)
Affinity DataKi:  8.70E+3nM ΔG°:  -28.6kJ/molepH: 7.4 T: 2°CAssay Description:The enzymatic reaction started by the addition fluorogenic peptide substrate, MAPKKide to the buffer containing LF and inhibitor compound. Cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM12006((1S,2R,3R,4S,5R)-5-amino-2-{[(2R,3R,4R,5S,6R)-3-am...)
Affinity DataKi:  8.80E+3nM ΔG°:  -28.6kJ/molepH: 7.4 T: 2°CAssay Description:The enzymatic reaction started by the addition fluorogenic peptide substrate, MAPKKide to the buffer containing LF and inhibitor compound. Cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM12011((2R,3R,4R,5S,6R)-2-{[(1R,2R,3S,4R,6S)-4-amino-6-ca...)
Affinity DataKi:  9.20E+3nM ΔG°:  -28.5kJ/molepH: 7.4 T: 2°CAssay Description:The enzymatic reaction started by the addition fluorogenic peptide substrate, MAPKKide to the buffer containing LF and inhibitor compound. Cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM12004((1R,2S,3R,4R,5S)-5-amino-4-{[(2R,3R,4R,5S,6R)-3-am...)
Affinity DataKi:  1.02E+4nM ΔG°:  -28.2kJ/molepH: 7.4 T: 2°CAssay Description:The enzymatic reaction started by the addition fluorogenic peptide substrate, MAPKKide to the buffer containing LF and inhibitor compound. Cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM8521(4-[(1S,2S,4S,5R)-2,4-bis(carbamimidamidomethyl)-5-...)
Affinity DataKi:  1.07E+4nM ΔG°:  -28.1kJ/molepH: 7.4 T: 2°CAssay Description:The enzymatic reaction started by the addition fluorogenic peptide substrate, MAPKKide to the buffer containing LF and inhibitor compound. Cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM12000((2R,3R,4R,5S,6R)-6-(aminomethyl)-2-{[(1R,2R,3S,4R,...)
Affinity DataKi:  1.09E+4nM ΔG°:  -28.0kJ/molepH: 7.4 T: 2°CAssay Description:The enzymatic reaction started by the addition fluorogenic peptide substrate, MAPKKide to the buffer containing LF and inhibitor compound. Cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM8515(4-[(1S,2S,4S,5R)-2,4-bis(carbamimidamidomethyl)-5-...)
Affinity DataKi:  1.49E+4nM ΔG°:  -27.3kJ/molepH: 7.4 T: 2°CAssay Description:The enzymatic reaction started by the addition fluorogenic peptide substrate, MAPKKide to the buffer containing LF and inhibitor compound. Cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM12001(3-{[(2R,3S,4R,5R,6R)-5-amino-6-{[(1R,2R,3S,4R,6S)-...)
Affinity DataKi:  2.43E+4nM ΔG°:  -26.1kJ/molepH: 7.4 T: 2°CAssay Description:The enzymatic reaction started by the addition fluorogenic peptide substrate, MAPKKide to the buffer containing LF and inhibitor compound. Cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM8523((1S,2R,4S,5R)-2,4-bis(carbamimidamidomethyl)-5-hyd...)
Affinity DataKi:  2.48E+4nM ΔG°:  -26.0kJ/molepH: 7.4 T: 2°CAssay Description:The enzymatic reaction started by the addition fluorogenic peptide substrate, MAPKKide to the buffer containing LF and inhibitor compound. Cleavage o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM8516(2-[(1S,2S,4S,5R)-2,4-bis(carbamimidamidomethyl)-5-...)
Affinity DataKi:  3.06E+4nM ΔG°:  -25.5kJ/molepH: 7.4 T: 2°CAssay Description:The enzymatic reaction started by the addition fluorogenic peptide substrate, MAPKKide to the buffer containing LF and inhibitor compound. Cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM8520(4-[(1S,2S,4S,5R)-2,4-bis(carbamimidamidomethyl)-5-...)
Affinity DataKi:  3.14E+4nM ΔG°:  -25.4kJ/molepH: 7.4 T: 2°CAssay Description:The enzymatic reaction started by the addition fluorogenic peptide substrate, MAPKKide to the buffer containing LF and inhibitor compound. Cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM8580((2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-{[(1R,2...)
Affinity DataKi:  4.29E+4nM ΔG°:  -24.7kJ/molepH: 7.4 T: 2°CAssay Description:The enzymatic reaction started by the addition fluorogenic peptide substrate, MAPKKide to the buffer containing LF and inhibitor compound. Cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech

LigandPNGBDBM8522(3-{[(1S,2S,4R,5S)-2-(2-amino-1H-1,3-benzodiazol-6-...)
Affinity DataKi:  1.54E+5nM ΔG°:  -21.5kJ/molepH: 7.4 T: 2°CAssay Description:The enzymatic reaction started by the addition fluorogenic peptide substrate, MAPKKide to the buffer containing LF and inhibitor compound. Cleavage o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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