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Found 466 of ph data with Target = 'Lysosomal acid glucosylceramidase'
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM85134(Isofagomine derivative, 7)
Affinity DataKi:  0.0700nMpH: 7.0Assay Description:Fluorescene-based assay using beta-glucocerebrosidase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM85134(Isofagomine derivative, 7)
Affinity DataKi:  0.200nMpH: 5.5Assay Description:Fluorescene-based assay using beta-glucocerebrosidase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50383315(CHEMBL2029773)
Affinity DataKi:  0.400nMpH: 5.0Assay Description:Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM108418(US8604206, 13 | US8604206, 14)
Affinity DataKi:  0.900nM IC50:  17.1nMpH: 7.0Assay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM162702(US9056847, Fluorophore 1-cyclophellitol)
Affinity DataKi:  0.950nM IC50:  2nMpH: 5.2Assay Description:Activity of GBA was measured at 37° C. with 4-methylumbelliferyl β-D-glucopyranoside as substrate as reported previously. To determine the IC50 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM108220(5-(hydroxymethyl)-2-[3-(4-methoxyphenyl)propyl]- 5...)
Affinity DataKi:  1.17nMpH: 5.2Assay Description:To determine inhibition constant (Ki), substrate (7.5µL, various concentrations in Mcllvaine buffer, pH 5.2) and enzyme (12.5µL, 0.1mg/mL) ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM108219(5-(hydroxymethyl)-2-[3-(4-methylphenyl)propyl]- 5H...)
Affinity DataKi:  1.46nMpH: 5.2Assay Description:To determine inhibition constant (Ki), substrate (7.5µL, various concentrations in Mcllvaine buffer, pH 5.2) and enzyme (12.5µL, 0.1mg/mL) ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM60418(US9056847, Fluorophore 2-cyclophellitol)
Affinity DataKi:  1.56nMpH: 5.2Assay Description:Activity of GBA was measured at 37° C. with 4-methylumbelliferyl β-D-glucopyranoside as substrate as reported previously. To determine the IC50 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50182801((3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8...)
Affinity DataKi:  1.70nMpH: 7.0Assay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50383327(CHEMBL2029772)
Affinity DataKi:  1.80nMpH: 5.0Assay Description:Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM108222(2-[3-(4-cyclohexylphenyl)propyl]-5-(hydroxymethyl)...)
Affinity DataKi:  1.93nMpH: 5.2Assay Description:To determine inhibition constant (Ki), substrate (7.5µL, various concentrations in Mcllvaine buffer, pH 5.2) and enzyme (12.5µL, 0.1mg/mL) ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM285821((6R,7R,8S)-8-(fluoromethyl)-4-azaspiro[2.5]octane-...)
Affinity DataKi:  2.10nMpH: 7.0Assay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM285819((6R,7R,8S)-8-methyl-4-azaspiro[2.5]octane-6,7-diol...)
Affinity DataKi:  2.60nMpH: 7.0Assay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50383321(CHEMBL2029780)
Affinity DataKi:  3nMpH: 5.0Assay Description:Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM108417(US8604206, 6)
Affinity DataKi:  3.06nM IC50:  5.80nMpH: 7.0Assay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM108216(5-(hydroxymethyl)-2-(2-phenylethyl)-5H,6H,7H,8H- i...)
Affinity DataKi:  3.19nMpH: 5.2Assay Description:To determine inhibition constant (Ki), substrate (7.5µL, various concentrations in Mcllvaine buffer, pH 5.2) and enzyme (12.5µL, 0.1mg/mL) ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM108223(2-[3-(4-fluorophenyl)propyl]-5-(hydroxymethyl)- 5H...)
Affinity DataKi:  3.48nMpH: 5.2Assay Description:To determine inhibition constant (Ki), substrate (7.5µL, various concentrations in Mcllvaine buffer, pH 5.2) and enzyme (12.5µL, 0.1mg/mL) ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM108221(5-(hydroxymethyl)-2-[3-(4-phenylphenyl)propyl]- 5H...)
Affinity DataKi:  3.62nMpH: 5.2Assay Description:To determine inhibition constant (Ki), substrate (7.5µL, various concentrations in Mcllvaine buffer, pH 5.2) and enzyme (12.5µL, 0.1mg/mL) ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM108418(US8604206, 13 | US8604206, 14)
Affinity DataKi:  4nM IC50:  7nMpH: 7.0Assay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50383323(CHEMBL2029778)
Affinity DataKi:  4nMpH: 5.0Assay Description:Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM108224(N-phenyl-4-[6,7,8-trihydroxy-5-(hydroxymethyl)- 5H...)
Affinity DataKi:  4.18nMpH: 5.2Assay Description:To determine inhibition constant (Ki), substrate (7.5µL, various concentrations in Mcllvaine buffer, pH 5.2) and enzyme (12.5µL, 0.1mg/mL) ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50383325(CHEMBL2029776)
Affinity DataKi:  4.40nMpH: 5.0Assay Description:Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50075408(5-(hydroxymethyl)piperidine-3,4-diol | CHEMBL34512...)
Affinity DataKi:  5nMpH: 7.0Assay Description:Fluorescene-based assay using beta-glucocerebrosidase.More data for this Ligand-Target Pair
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM108217(2-(3,3-dimethylbutyl)-5-(hydroxymethyl)- 5H,6H,7H,...)
Affinity DataKi:  5.34nMpH: 5.2Assay Description:To determine inhibition constant (Ki), substrate (7.5µL, various concentrations in Mcllvaine buffer, pH 5.2) and enzyme (12.5µL, 0.1mg/mL) ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM108218(5-(hydroxymethyl)-2-octyl-5H,6H,7H,8H-imidazo[1,2-...)
Affinity DataKi:  5.38nMpH: 5.2Assay Description:To determine inhibition constant (Ki), substrate (7.5µL, various concentrations in Mcllvaine buffer, pH 5.2) and enzyme (12.5µL, 0.1mg/mL) ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50383324(CHEMBL2029777)
Affinity DataKi:  6nMpH: 5.0Assay Description:Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM285839((6R,7R,8S)-8-(prop-1-yn-1-yl)-4-azaspiro[2.5]octan...)
Affinity DataKi:  6.70nMpH: 7.0Assay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM36514(CID46912122 | MDW933, 5)
Affinity DataKi:  7nM ΔG°:  -48.4kJ/mole IC50:  1.24nMpH: 5.2 T: 2°CAssay Description:Enzymatic activity assay using fluorescent activity-based labeling method.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM285820((6R,7R,8R)-8-(hydroxymethyl)-4-azaspiro[2.5]octane...)
Affinity DataKi:  7nMpH: 7.0Assay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM285834((6R,7R,8S)-8-vinyl-4-azaspiro[2.5]octane-6,7-diol ...)
Affinity DataKi:  7.60nMpH: 7.0Assay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM285838((6R,7R,8S)-8-ethynyl-4-azaspiro[2.5]octane-6,7-dio...)
Affinity DataKi:  7.90nMpH: 7.0Assay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM36515(CID46912120 | MDW941, 6)
Affinity DataKi:  8nM ΔG°:  -48.1kJ/mole IC50:  1.94nMpH: 5.2 T: 2°CAssay Description:Enzymatic activity assay using fluorescent activity-based labeling method.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM285822((6R,7R,8S)-8-(difluoromethyl)-4-azaspiro[2.5]octan...)
Affinity DataKi:  8nMpH: 7.0Assay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM108423(US8604206, (3R,4R,5R)-5((S)-hydroxy(phenyl)methyl)...)
Affinity DataKi:  8.90nM IC50:  17nMpH: 7.0Assay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM108419(US8604206, 10 | US8604206, 9)
Affinity DataKi:  10nM IC50:  20nMpH: 7.0Assay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50383319(CHEMBL2029782)
Affinity DataKi:  12nMpH: 5.0Assay Description:Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM108417(US8604206, 6)
Affinity DataKi:  13.6nM IC50:  25.9nMpH: 5.2Assay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM108424(US8604206, (3R,4R,5S)-5(2-hydroxypropan-2-yl)piper...)
Affinity DataKi:  15nM IC50:  29nMpH: 7.0Assay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM285843((6R,7R,8S)-8-(3-fluoroprop-1-yn-1-yl)-4-azaspiro[2...)
Affinity DataKi:  15nMpH: 7.0Assay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM108418(US8604206, 13 | US8604206, 14)
Affinity DataKi:  16nM IC50:  38nMpH: 5.2Assay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM285844((6R,7R,8S)-8-(3,3-difluoroprop-1-yn-1-yl)-4-azaspi...)
Affinity DataKi:  17nMpH: 7.0Assay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50383328(CHEMBL2029771)
Affinity DataKi:  18nMpH: 5.0Assay Description:Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM108225(2,2-dimethyl-N-phenyl-5-[6,7,8-trihydroxy-5- (hydr...)
Affinity DataKi:  18.9nMpH: 5.2Assay Description:To determine inhibition constant (Ki), substrate (7.5µL, various concentrations in Mcllvaine buffer, pH 5.2) and enzyme (12.5µL, 0.1mg/mL) ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50383322(CHEMBL2029779)
Affinity DataKi:  19nMpH: 5.0Assay Description:Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM18428(Aminoquinoline compound, 1 | N-[4-methyl-2-(morpho...)
Affinity DataKi:  21nM ΔG°:  -43.2kJ/mole IC50:  31nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50075408(5-(hydroxymethyl)piperidine-3,4-diol | CHEMBL34512...)
Affinity DataKi:  23nMpH: 5.5Assay Description:Fluorescene-based assay using beta-glucocerebrosidase.More data for this Ligand-Target Pair
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50379102(CHEMBL2012655)
Affinity DataKi:  26nMpH: 5.2Assay Description:Competitive inhibition of human recombinant beta-glucocerebrosidase assessed as 4-methyumbelliferone formation after 30 mins by Lineweaver-Burk plot ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50383326(CHEMBL2029775)
Affinity DataKi:  29nMpH: 5.0Assay Description:Competitive inhibition of wild type human glucocerebrosidase using 2,4-dinitrophenyl beta-D-glucopyranoside as substrate after 3 mins by Dixon and Li...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50383318(CHEMBL2029783)
Affinity DataKi:  30nMpH: 5.0Assay Description:Competitive inhibition of wild type human glucocerebrosidase using 2,4-dinitrophenyl beta-D-glucopyranoside as substrate after 3 mins by Dixon and Li...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM108215(5-(hydroxymethyl)-5H,6H,7H,8H-imidazo[1,2- a]pyrid...)
Affinity DataKi:  33.1nMpH: 5.2Assay Description:To determine inhibition constant (Ki), substrate (7.5µL, various concentrations in Mcllvaine buffer, pH 5.2) and enzyme (12.5µL, 0.1mg/mL) ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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