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Found 15 of ph data with Target = 'Myeloperoxidase'
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM119872(3‐(2‐ethoxypropyl)‐2‐sulfa...)
Affinity DataKi:  413nMpH: 7.4Assay Description:Assay mixtures (100 µL) contained 50 mM NaPi (pH 7.4), 150 mM NaCl, 1 mM DTPA, 2% DMSO, the indicated concentrations of H2O2, and Amplex Red. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM119874(3‐[(2S)‐2‐ethoxypropyl]‐2&...)
Affinity DataKi:  429nMpH: 7.4Assay Description:Assay mixtures (100 µL) contained 50 mM NaPi (pH 7.4), 150 mM NaCl, 1 mM DTPA, 2% DMSO, the indicated concentrations of H2O2, and Amplex Red. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM119873(3‐[(2R)‐2‐ethoxypropyl]‐2&...)
Affinity DataKi:  546nMpH: 7.4Assay Description:Assay mixtures (100 µL) contained 50 mM NaPi (pH 7.4), 150 mM NaCl, 1 mM DTPA, 2% DMSO, the indicated concentrations of H2O2, and Amplex Red. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM217354(2-(3,5-bistrifluoromethylbenzylamino)-6-oxo-1H-pyr...)
Affinity DataIC50:  5.01nMpH: 6.5Assay Description:Assays were performed at 22 °C with 2 nM MPO and 10 μM hydrogen peroxide (H2O2) in 20 mM NaH2PO4 buffer, pH 6.5 containing 140 mM NaCl, 10 mM ta...More data for this Ligand-Target Pair
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM217355(4-benzyl-2-hydroxybenzenecarbohydroxamic acid (HX2...)
Affinity DataIC50:  25.1nMpH: 6.5Assay Description:Assays were performed at 22 °C with 2 nM MPO and 10 μM hydrogen peroxide (H2O2) in 20 mM NaH2PO4 buffer, pH 6.5 containing 140 mM NaCl, 10 mM ta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM92469(2-Thioxanthine, TX4)
Affinity DataIC50:  200nMpH: 7.4 T: 2°CAssay Description:The chlorination activity of MPO was determined by measuring the production of hypocholorous acid. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM92467(2-Thioxanthine, TX2)
Affinity DataIC50:  200nMpH: 7.4 T: 2°CAssay Description:The chlorination activity of MPO was determined by measuring the production of hypocholorous acid. More data for this Ligand-Target Pair
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM92468(2-Thioxanthine, TX3)
Affinity DataIC50:  400nMpH: 7.4 T: 2°CAssay Description:The chlorination activity of MPO was determined by measuring the production of hypocholorous acid. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM92470(2-Thioxanthine, TX5)
Affinity DataIC50:  400nMpH: 7.4 T: 2°CAssay Description:The chlorination activity of MPO was determined by measuring the production of hypocholorous acid. More data for this Ligand-Target Pair
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM217356(2-(benzylamino)-6-oxo-3H-pyrimidine-5-carbohydroxa...)
Affinity DataIC50:  790nMpH: 6.5Assay Description:Assays were performed at 22 °C with 2 nM MPO and 10 μM hydrogen peroxide (H2O2) in 20 mM NaH2PO4 buffer, pH 6.5 containing 140 mM NaCl, 10 mM ta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM92466(2-Thioxanthine, TX1)
Affinity DataIC50:  1.00E+3nMpH: 7.4 T: 2°CAssay Description:The chlorination activity of MPO was determined by measuring the production of hypocholorous acid. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50015089(2,N-Dihydroxy-benzamide | CHEMBL309339 | N,2-dihyd...)
Affinity DataIC50:  2.50E+4nMpH: 6.5Assay Description:Assays were performed at 22 °C with 2 nM MPO and 10 μM hydrogen peroxide (H2O2) in 20 mM NaH2PO4 buffer, pH 6.5 containing 140 mM NaCl, 10 mM ta...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM217356(2-(benzylamino)-6-oxo-3H-pyrimidine-5-carbohydroxa...)
Affinity DataKd:  2.00E+3nMpH: 5.0Assay Description:Binding kinetics were determined by surface plasmon resonance (SPR) using a Biacore S51 (Biacore, Uppsala, Sweden). MPO (50 μg/ml dissolved in 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM217354(2-(3,5-bistrifluoromethylbenzylamino)-6-oxo-1H-pyr...)
Affinity DataKd:  15.8nMpH: 5.0Assay Description:Binding kinetics were determined by surface plasmon resonance (SPR) using a Biacore S51 (Biacore, Uppsala, Sweden). MPO (50 μg/ml dissolved in 1...More data for this Ligand-Target Pair
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM217355(4-benzyl-2-hydroxybenzenecarbohydroxamic acid (HX2...)
Affinity DataKd:  63nMpH: 5.0Assay Description:Binding kinetics were determined by surface plasmon resonance (SPR) using a Biacore S51 (Biacore, Uppsala, Sweden). MPO (50 μg/ml dissolved in 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed