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Found 1382 of ph data with Target = 'Neutrophil elastase'
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23698(4-chloro-1-[(4-fluorophenyl)carbonyl]-1H-pyrazole ...)
Affinity DataKi:  6nM ΔG°:  -46.9kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23700(N-Benzoylpyrazole deriv., 2 | methyl 1-[(4-chlorop...)
Affinity DataKi:  15nM ΔG°:  -44.7kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23709(3-methyl-1-[(3,4,5-trimethoxyphenyl)carbonyl]-1H-p...)
Affinity DataKi:  21nM ΔG°:  -43.8kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23701(4-chloro-1-[(3-nitrophenyl)carbonyl]-1H-pyrazole |...)
Affinity DataKi:  24nM ΔG°:  -43.5kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23702(3-[(2,4-dimethylphenyl)carbonyl]-1-[(4-fluoropheny...)
Affinity DataKi:  24nM ΔG°:  -43.5kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23710(1-[(4-methylphenyl)carbonyl]-3-nitro-1H-pyrazole |...)
Affinity DataKi:  28nM ΔG°:  -43.1kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23703(1-benzoyl-4-nitro-1H-pyrazole | N-Benzoylpyrazole ...)
Affinity DataKi:  34nM ΔG°:  -42.6kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23704(1-benzoyl-N-phenyl-1H-pyrazole-3-carboxamide | N-B...)
Affinity DataKi:  39nM ΔG°:  -42.3kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23705(4-bromo-1-[(4-methylphenyl)carbonyl]-1H-pyrazole |...)
Affinity DataKi:  45nM ΔG°:  -41.9kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23711(1-benzoyl-3-nitro-1H-pyrazole | N-Benzoylpyrazole ...)
Affinity DataKi:  46nM ΔG°:  -41.9kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23712(1-[(2-methylphenyl)carbonyl]-4-nitro-1H-pyrazole |...)
Affinity DataKi:  65nM ΔG°:  -41.0kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23706(1-[(3,4-dichlorophenyl)carbonyl]-1H-pyrazole | N-B...)
Affinity DataKi:  104nM ΔG°:  -39.9kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23707(1-[(2-fluorophenyl)carbonyl]-5-methyl-3-nitro-1H-p...)
Affinity DataKi:  107nM ΔG°:  -39.8kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23726(1,1-dimethylprop-2-yn-1-yl 4-methoxybenzoate, 10 |...)
Affinity DataKi:  110nM ΔG°:  -39.7kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23713(4-chloro-1-[(2-methylphenyl)carbonyl]-1H-pyrazole ...)
Affinity DataKi:  230nM ΔG°:  -37.9kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23714(4-bromo-1-[(3-methylphenyl)carbonyl]-1H-pyrazole |...)
Affinity DataKi:  250nM ΔG°:  -37.7kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23727(N,N-bis(cyanomethyl)-3,4-dimethoxybenzamide | N,N-...)
Affinity DataKi:  290nM ΔG°:  -37.3kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23716(N-Benzoylpyrazole deriv., 24 | N-{4-[(3-methyl-1H-...)
Affinity DataKi:  300nM ΔG°:  -37.2kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23715(4-bromo-1-[(2-methylphenyl)carbonyl]-1H-pyrazole |...)
Affinity DataKi:  300nM ΔG°:  -37.2kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23728(2-(2-methoxyphenoxy)-N'-(thiophen-2-ylcarbonyl)ace...)
Affinity DataKi:  820nM ΔG°:  -34.7kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23717(4-chloro-1-[(2-chlorophenyl)carbonyl]-1H-pyrazole ...)
Affinity DataKi:  1.00E+3nM ΔG°:  -34.2kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23708(4-bromo-1-[(2,6-difluorophenyl)carbonyl]-1H-pyrazo...)
Affinity DataKi:  1.10E+3nM ΔG°:  -34.0kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23718(1-[(2-methylphenyl)carbonyl]-1H-pyrazole | N-Benzo...)
Affinity DataKi:  3.40E+3nM ΔG°:  -31.2kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23719(4-bromo-1-[(2-chloro-4,5-difluorophenyl)carbonyl]-...)
Affinity DataKi:  7.20E+3nM ΔG°:  -29.4kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23721(4-chloro-1-[(2-fluorophenyl)carbonyl]-3,5-dimethyl...)
Affinity DataKi:  9.00E+3nM ΔG°:  -28.8kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23720(1-[(4-tert-butylphenyl)carbonyl]-4-chloro-1H-pyraz...)
Affinity DataKi:  9.00E+3nM ΔG°:  -28.8kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23722(4-chloro-1-[(4-chlorophenyl)carbonyl]-3,5-dimethyl...)
Affinity DataKi:  1.07E+4nM ΔG°:  -28.4kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23723(4-bromo-1-[(4-methoxyphenyl)carbonyl]-3,5-dimethyl...)
Affinity DataKi:  2.45E+4nM ΔG°:  -26.3kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23724(1-[(2-bromophenyl)carbonyl]-1H-pyrazole | N-Benzoy...)
Affinity DataKi:  2.99E+4nM ΔG°:  -25.8kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23725(3,4,5-trimethyl-1-[(3,4,5-trimethoxyphenyl)carbony...)
Affinity DataKi:  5.09E+4nM ΔG°:  -24.5kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM50068279(CHEMBL359047 | {(S)-1-[(S)-1-((R)-2-{(S)-1-[(S)-1-...)
Affinity DataKi:  6.50E+4nMpH: 8.0Assay Description:Inhibition constant of compound measured toward human leukocyte elastase (HLE) at pH 8 and 25 degree C.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM50068278(((S)-1-{(S)-2-[(R)-2-(N'-{(S)-1-[(S)-1-((S)-1-Isop...)
Affinity DataKi:  5.95E+5nMpH: 8.0Assay Description:Inhibition constant of compound measured toward human leukocyte elastase (HLE) at pH 8 and 25 degree C.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM189813(US9174997, 12)
Affinity DataIC50: <0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM211514(US9290457, Example 1.56)
Affinity DataIC50:  0.300nMpH: 7.5 T: 2°CAssay Description:Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM189815(US9174997, 18)
Affinity DataIC50: <0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM189814(US9174997, 14)
Affinity DataIC50: <0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM189818(US9174997, 27)
Affinity DataIC50: <0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM189819(US9174997, 32)
Affinity DataIC50: <0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM189820(US9174997, 33)
Affinity DataIC50: <0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM189821(US9174997, 36)
Affinity DataIC50: <0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM189822(US9174997, 41)
Affinity DataIC50: <0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM189823(US9174997, 43 (Diastereomer 1))
Affinity DataIC50:  0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM189831(US9174997, 51)
Affinity DataIC50: <0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM189835(US9174997, 55)
Affinity DataIC50: <0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM189812(US9174997, 10)
Affinity DataIC50: <0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM189860(US9174997, 80)
Affinity DataIC50: <0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM189865(US9174997, 85)
Affinity DataIC50: <0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM189871(US9174997, 91)
Affinity DataIC50: <0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM189876(US9174997, 96)
Affinity DataIC50: <0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM189883(US9174997, 103)
Affinity DataIC50: <0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In DepthDetails US Patent
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