Affinity DataIC50: 11nMpH: 8.0 T: 2°CAssay Description:Dilute 3 mL of assay buffer concentrate with 27 mL of HPLC - grade water. This final assay buffer (0.1 M Tris-HCl, pH 8) should be used for dilution ...More data for this Ligand-Target Pair
Affinity DataIC50: 14nMpH: 8.0 T: 2°CAssay Description:Dilute 3 mL of assay buffer concentrate with 27 mL of HPLC - grade water. This final assay buffer (0.1 M Tris-HCl, pH 8) should be used for dilution ...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMpH: 8.0 T: 2°CAssay Description:Dilute 3 mL of assay buffer concentrate with 27 mL of HPLC - grade water. This final assay buffer (0.1 M Tris-HCl, pH 8) should be used for dilution ...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMpH: 8.0 T: 2°CAssay Description:Dilute 3 mL of assay buffer concentrate with 27 mL of HPLC - grade water. This final assay buffer (0.1 M Tris-HCl, pH 8) should be used for dilution ...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMpH: 8.0 T: 2°CAssay Description:Dilute 3 mL of assay buffer concentrate with 27 mL of HPLC - grade water. This final assay buffer (0.1 M Tris-HCl, pH 8) should be used for dilution ...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMpH: 8.0 T: 2°CAssay Description:Dilute 3 mL of assay buffer concentrate with 27 mL of HPLC - grade water. This final assay buffer (0.1 M Tris-HCl, pH 8) should be used for dilution ...More data for this Ligand-Target Pair
Affinity DataIC50: 24nMpH: 8.0 T: 2°CAssay Description:Dilute 3 mL of assay buffer concentrate with 27 mL of HPLC - grade water. This final assay buffer (0.1 M Tris-HCl, pH 8) should be used for dilution ...More data for this Ligand-Target Pair
Affinity DataIC50: 34nMpH: 8.0 T: 2°CAssay Description:Dilute 3 mL of assay buffer concentrate with 27 mL of HPLC - grade water. This final assay buffer (0.1 M Tris-HCl, pH 8) should be used for dilution ...More data for this Ligand-Target Pair
Affinity DataIC50: 35nMpH: 8.0 T: 2°CAssay Description:Dilute 3 mL of assay buffer concentrate with 27 mL of HPLC - grade water. This final assay buffer (0.1 M Tris-HCl, pH 8) should be used for dilution ...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMpH: 8.0 T: 2°CAssay Description:Dilute 3 mL of assay buffer concentrate with 27 mL of HPLC - grade water. This final assay buffer (0.1 M Tris-HCl, pH 8) should be used for dilution ...More data for this Ligand-Target Pair
Affinity DataIC50: 59nMpH: 8.0 T: 2°CAssay Description:Dilute 3 mL of assay buffer concentrate with 27 mL of HPLC - grade water. This final assay buffer (0.1 M Tris-HCl, pH 8) should be used for dilution ...More data for this Ligand-Target Pair
Affinity DataIC50: 68nMpH: 8.0 T: 2°CAssay Description:Tested compounds (50 uM), DuP-597 (0.5 uM; positive control), 11f and 11eie(1 nM - 200 uM ) or vehicle were pre-incubated with COX-FIS assay buffer (...More data for this Ligand-Target Pair
Affinity DataIC50: 70nMpH: 8.0 T: 2°CAssay Description:The COX enzyme activities were measured using the COX Inhibitor Screening Assay kit provided by Cayman (Cayman, Chemical Co., Ann Arbor, MI). The as...More data for this Ligand-Target Pair
Affinity DataIC50: 70nMpH: 8.0 T: 2°CAssay Description:COX fluorescent inhibitor screening assay kit (catalog number 700100, Cayman chemical, Ann Arbour, MI, USA) has been employed to investigate the isoz...More data for this Ligand-Target Pair
Affinity DataIC50: 71nMpH: 8.0 T: 2°CAssay Description:Tested compounds (50 uM), DuP-597 (0.5 uM; positive control), 11f and 11eie(1 nM - 200 uM ) or vehicle were pre-incubated with COX-FIS assay buffer (...More data for this Ligand-Target Pair
Affinity DataIC50: 75nMpH: 8.0 T: 2°CAssay Description:Dilute 3 mL of assay buffer concentrate with 27 mL of HPLC - grade water. This final assay buffer (0.1 M Tris-HCl, pH 8) should be used for dilution ...More data for this Ligand-Target Pair
Affinity DataIC50: 77nMpH: 8.0 T: 2°CAssay Description:Dilute 3 mL of assay buffer concentrate with 27 mL of HPLC - grade water. This final assay buffer (0.1 M Tris-HCl, pH 8) should be used for dilution ...More data for this Ligand-Target Pair
Affinity DataIC50: 85nMpH: 8.0 T: 2°CAssay Description:Dilute 3 mL of assay buffer concentrate with 27 mL of HPLC - grade water. This final assay buffer (0.1 M Tris-HCl, pH 8) should be used for dilution ...More data for this Ligand-Target Pair
Affinity DataIC50: 85nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...More data for this Ligand-Target Pair
Affinity DataIC50: 90nMpH: 8.0 T: 2°CAssay Description:Selected 1,3,4-oxadiazole derivatives (4a, 4b, 4c, 4e, 6b, 6e, 8b) were tested for their ability to inhibit COX-1 and COX-2 using a COX-(ovine) inhib...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...More data for this Ligand-Target Pair
Affinity DataIC50: 106nMpH: 8.0 T: 2°CAssay Description:Dilute 3 mL of assay buffer concentrate with 27 mL of HPLC - grade water. This final assay buffer (0.1 M Tris-HCl, pH 8) should be used for dilution ...More data for this Ligand-Target Pair
Affinity DataIC50: 170nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...More data for this Ligand-Target Pair
Affinity DataIC50: 220nMpH: 8.0 T: 2°CAssay Description:The reaction mixture contained reaction buffer solution (950 uL, 0.1 M Tris-HCl, pH 8.0 containing 5 mM EDTA and 2 mM phenol), COX-1 or COX-2 (10 uL)...More data for this Ligand-Target Pair
Affinity DataIC50: 250nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...More data for this Ligand-Target Pair
Affinity DataIC50: 270nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...More data for this Ligand-Target Pair
Affinity DataIC50: 280nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...More data for this Ligand-Target Pair
Affinity DataIC50: 400nMpH: 8.0 T: 2°CAssay Description:Selected 1,3,4-oxadiazole derivatives (4a, 4b, 4c, 4e, 6b, 6e, 8b) were tested for their ability to inhibit COX-1 and COX-2 using a COX-(ovine) inhib...More data for this Ligand-Target Pair
Affinity DataIC50: 440nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...More data for this Ligand-Target Pair
Affinity DataIC50: 500nMpH: 8.0 T: 2°CAssay Description:The COX enzyme activities were measured using the COX Inhibitor Screening Assay kit provided by Cayman (Cayman, Chemical Co., Ann Arbor, MI). The as...More data for this Ligand-Target Pair
Affinity DataIC50: 750nMpH: 8.0 T: 2°CAssay Description:COX fluorescent inhibitor screening assay kit (catalog number 700100, Cayman chemical, Ann Arbour, MI, USA) has been employed to investigate the isoz...More data for this Ligand-Target Pair
Affinity DataIC50: 800nMpH: 8.0 T: 2°CAssay Description:Tested compounds (50 uM), DuP-597 (0.5 uM; positive control), 11f and 11eie(1 nM - 200 uM ) or vehicle were pre-incubated with COX-FIS assay buffer (...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...More data for this Ligand-Target Pair
Affinity DataIC50: 1.18E+3nMpH: 8.0 T: 2°CAssay Description:Selected 1,3,4-oxadiazole derivatives (4a, 4b, 4c, 4e, 6b, 6e, 8b) were tested for their ability to inhibit COX-1 and COX-2 using a COX-(ovine) inhib...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMpH: 8.0 T: 2°CAssay Description:Selected 1,3,4-oxadiazole derivatives (4a, 4b, 4c, 4e, 6b, 6e, 8b) were tested for their ability to inhibit COX-1 and COX-2 using a COX-(ovine) inhib...More data for this Ligand-Target Pair
Affinity DataIC50: 1.68E+3nMpH: 8.0 T: 2°CAssay Description:The reaction mixture contained reaction buffer solution (950 uL, 0.1 M Tris-HCl, pH 8.0 containing 5 mM EDTA and 2 mM phenol), COX-1 or COX-2 (10 uL)...More data for this Ligand-Target Pair
Affinity DataIC50: 1.73E+3nMpH: 8.0 T: 2°CAssay Description:The reaction mixture contained reaction buffer solution (950 uL, 0.1 M Tris-HCl, pH 8.0 containing 5 mM EDTA and 2 mM phenol), COX-1 or COX-2 (10 uL)...More data for this Ligand-Target Pair
Affinity DataIC50: 1.76E+3nMpH: 8.0 T: 2°CAssay Description:The reaction mixture contained reaction buffer solution (950 uL, 0.1 M Tris-HCl, pH 8.0 containing 5 mM EDTA and 2 mM phenol), COX-1 or COX-2 (10 uL)...More data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+3nMpH: 8.0 T: 2°CAssay Description:Reaction mixtures were prepared in 100 mM Tris¿HCl buffer, pH 8.0 containing 1 µM heme and COX-1 or COX-2 and preincubated for 10 min in a waterbath ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.12E+3nMpH: 8.0 T: 2°CAssay Description:The reaction mixture contained reaction buffer solution (950 uL, 0.1 M Tris-HCl, pH 8.0 containing 5 mM EDTA and 2 mM phenol), COX-1 or COX-2 (10 uL)...More data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+3nMpH: 8.0 T: 2°CAssay Description:Tested compounds (50 uM), DuP-597 (0.5 uM; positive control), 11f and 11eie(1 nM - 200 uM ) or vehicle were pre-incubated with COX-FIS assay buffer (...More data for this Ligand-Target Pair
Affinity DataIC50: 2.22E+3nMpH: 8.0 T: 2°CAssay Description:The reaction mixture contained reaction buffer solution (950 uL, 0.1 M Tris-HCl, pH 8.0 containing 5 mM EDTA and 2 mM phenol), COX-1 or COX-2 (10 uL)...More data for this Ligand-Target Pair
Affinity DataIC50: 2.26E+3nMpH: 8.0 T: 2°CAssay Description:The reaction mixture contained reaction buffer solution (950 uL, 0.1 M Tris-HCl, pH 8.0 containing 5 mM EDTA and 2 mM phenol), COX-1 or COX-2 (10 uL)...More data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+3nMpH: 8.0 T: 2°CAssay Description:The COX enzyme activities were measured using the COX Inhibitor Screening Assay kit provided by Cayman (Cayman, Chemical Co., Ann Arbor, MI). The as...More data for this Ligand-Target Pair
Affinity DataIC50: 2.46E+3nMpH: 8.0 T: 2°CAssay Description:The reaction mixture contained reaction buffer solution (950 uL, 0.1 M Tris-HCl, pH 8.0 containing 5 mM EDTA and 2 mM phenol), COX-1 or COX-2 (10 uL)...More data for this Ligand-Target Pair
Affinity DataIC50: 2.65E+3nMpH: 8.0 T: 2°CAssay Description:The reaction mixture contained reaction buffer solution (950 uL, 0.1 M Tris-HCl, pH 8.0 containing 5 mM EDTA and 2 mM phenol), COX-1 or COX-2 (10 uL)...More data for this Ligand-Target Pair
Affinity DataIC50: 3.24E+3nMpH: 8.0 T: 2°CAssay Description:Reaction mixture containing 100 mM Tris-HCl buffer (pH 8) and COX-1 (ovine) or COX-2 (human recombinant) was preincubated for 10 min in a water bath ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.30E+3nMpH: 8.0 T: 2°CAssay Description:COX fluorescent inhibitor screening assay kit (catalog number 700100, Cayman chemical, Ann Arbour, MI, USA) has been employed to investigate the isoz...More data for this Ligand-Target Pair
Affinity DataIC50: 3.44E+3nMpH: 8.0 T: 2°CAssay Description:100 mM Tris¿HCl buffer, pH 8.0 containing 1 µM heme and COX-1 (ovine) or COX-2(human recombinant), which was preincubated for 10 min in a water bath ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.51E+3nMpH: 8.0 T: 2°CAssay Description:The reaction mixture contained reaction buffer solution (950 uL, 0.1 M Tris-HCl, pH 8.0 containing 5 mM EDTA and 2 mM phenol), COX-1 or COX-2 (10 uL)...More data for this Ligand-Target Pair