Compile Data Set for Download or QSAR
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Found 83 of ph data with Target = 'Replicase polyprotein 1ab'
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM59242(Benzotriazole ester, 8 | acs.jmedchem.1c00409_ST.6...)
Affinity DataKi:  7.5nMpH: 7.5Assay Description:Inhibition assay against SARS-CoV 3CL protease, a fluorometric assay was utilized to determine the inhibition constants of the samples.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM59240(Benzotriazole ester, 6 | acs.jmedchem.1c00409_ST.8)
Affinity DataKi:  11.1nMpH: 7.5Assay Description:Inhibition assay against SARS-CoV 3CL protease, a fluorometric assay was utilized to determine the inhibition constants of the samples.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM59239(Benzotriazole ester, 5 | acs.jmedchem.1c00409_ST.9)
Affinity DataKi:  12.1nMpH: 7.5Assay Description:Inhibition assay against SARS-CoV 3CL protease, a fluorometric assay was utilized to determine the inhibition constants of the samples.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM59243(Benzotriazole ester, 9 | acs.jmedchem.1c00409_ST.1...)
Affinity DataKi:  12.3nMpH: 7.5Assay Description:Inhibition assay against SARS-CoV 3CL protease, a fluorometric assay was utilized to determine the inhibition constants of the samples.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM59244(Benzotriazole ester, 10 | acs.jmedchem.1c00409_ST....)
Affinity DataKi:  13.8nMpH: 7.5Assay Description:Inhibition assay against SARS-CoV 3CL protease, a fluorometric assay was utilized to determine the inhibition constants of the samples.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM59238(Benzotriazole ester, 4 | acs.jmedchem.1c00409_ST.1...)
Affinity DataKi:  17.4nMpH: 7.5Assay Description:Inhibition assay against SARS-CoV 3CL protease, a fluorometric assay was utilized to determine the inhibition constants of the samples.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM59237(Benzotriazole ester, 3 | acs.jmedchem.1c00409_ST.1...)
Affinity DataKi:  19.5nMpH: 7.5Assay Description:Inhibition assay against SARS-CoV 3CL protease, a fluorometric assay was utilized to determine the inhibition constants of the samples.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM59241(Benzotriazole ester, 7)
Affinity DataKi:  22.9nMpH: 7.5Assay Description:Inhibition assay against SARS-CoV 3CL protease, a fluorometric assay was utilized to determine the inhibition constants of the samples.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM11234((2S)-N-(2-chloro-4-nitrophenyl)-2-{[4-(dimethylami...)
Affinity DataKi:  30nM ΔG°:  -42.9kJ/mole IC50:  60nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM92520(TG-0204998)
Affinity DataKi:  38nM ΔG°:  -42.4kJ/molepH: 6.5 T: 2°CAssay Description:Peptidomimetic inhibitors against CVB3 3Cpro and SARS-CoV 3CLpro. The inhibition constant of SARS 3CLpro was analyzed with reverse-phase HPLC using a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM11233(N-[(benzyloxy)carbonyl]-O-(tert-butyl)-L-threonyl-...)
Affinity DataKi:  53nM ΔG°:  -41.5kJ/molepH: 7.5 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using peptide cleavage assay. Cleavage products were resolved and analyzed with a reverse...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM11233(N-[(benzyloxy)carbonyl]-O-(tert-butyl)-L-threonyl-...)
Affinity DataKi:  54nM ΔG°:  -41.5kJ/molepH: 6.5 T: 2°CAssay Description:Peptidomimetic inhibitors against CVB3 3Cpro and SARS-CoV 3CLpro. The inhibition constant of SARS 3CLpro was analyzed with reverse-phase HPLC using a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM11232(N-[(benzyloxy)carbonyl]-O-(tert-butyl)-L-threonyl-...)
Affinity DataKi:  58nM ΔG°:  -41.3kJ/molepH: 7.5 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using peptide cleavage assay. Cleavage products were resolved and analyzed with a reverse...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM11232(N-[(benzyloxy)carbonyl]-O-(tert-butyl)-L-threonyl-...)
Affinity DataKi:  58nM ΔG°:  -41.3kJ/molepH: 6.5 T: 2°CAssay Description:Peptidomimetic inhibitors against CVB3 3Cpro and SARS-CoV 3CLpro. The inhibition constant of SARS 3CLpro was analyzed with reverse-phase HPLC using a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM92521(TG-0205486)
Affinity DataKi:  99nM ΔG°:  -40.0kJ/molepH: 6.5 T: 2°CAssay Description:Peptidomimetic inhibitors against CVB3 3Cpro and SARS-CoV 3CLpro. The inhibition constant of SARS 3CLpro was analyzed with reverse-phase HPLC using a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM11261(dipeptidomimetic unsaturated ester 18c | ethyl (2E...)
Affinity DataKi:  520nM ΔG°:  -35.9kJ/mole IC50:  1.00E+3nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM11231(N-[(benzyloxy)carbonyl]-L-valyl-N1-((1S,2E)-4-etho...)
Affinity DataKi:  660nM ΔG°:  -35.3kJ/molepH: 7.5 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using peptide cleavage assay. Cleavage products were resolved and analyzed with a reverse...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM59246(Benzotriazole ester, 14)
Affinity DataKi:  1.00E+3nMpH: 7.5Assay Description:Inhibition assay against SARS-CoV 3CL protease, a fluorometric assay was utilized to determine the inhibition constants of the samples.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM11240(Anilide Inhibitor 4k | N-[(benzyloxy)carbonyl]-L-v...)
Affinity DataKi:  1.51E+3nM ΔG°:  -33.2kJ/mole IC50:  6.00E+3nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM11239((2S)-N-[(1S)-1-{[(1S,2S)-1-{[(1S)-1-[(2-chloro-4-n...)
Affinity DataKi:  1.61E+3nM ΔG°:  -33.1kJ/mole IC50:  5.00E+3nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM11230(AG7088 analogue 2d | CHEMBL277716 | N-[(benzyloxy)...)
Affinity DataKi:  2.26E+3nM ΔG°:  -32.2kJ/molepH: 7.5 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using peptide cleavage assay. Cleavage products were resolved and analyzed with a reverse...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM11236((2S)-N-[(1S)-1-[(2-chloro-4-nitrophenyl)carbamoyl]...)
Affinity DataKi:  2.29E+3nM ΔG°:  -32.2kJ/mole IC50:  5.00E+3nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM11260(dipeptidomimetic unsaturated ester 18b | ethyl (2E...)
Affinity DataKi:  2.48E+3nM ΔG°:  -32.0kJ/mole IC50:  5.00E+3nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM11237((2S)-N-[(1S)-1-{[(1S)-1-[(2-chloro-4-nitrophenyl)c...)
Affinity DataKi:  2.90E+3nM ΔG°:  -31.6kJ/mole IC50:  7.00E+3nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM11263(dipeptidomimetic unsaturated ester 18e | ethyl (2E...)
Affinity DataKi:  3.05E+3nM ΔG°:  -31.5kJ/mole IC50:  7.00E+3nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM11241((2S)-N,N'-bis[(1S)-1-[(2-chloro-4-nitrophenyl)carb...)
Affinity DataKi:  3.10E+3nM ΔG°:  -31.4kJ/mole IC50:  4.00E+3nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM11238((2S)-N-[(1S)-1-{[(1S)-1-[(2-chloro-4-nitrophenyl)c...)
Affinity DataKi:  4.30E+3nM ΔG°:  -30.6kJ/mole IC50:  5.00E+3nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM59249(Benzotriazole ester, 17 | acs.jmedchem.1c00409_ST....)
Affinity DataKi:  4.50E+3nMpH: 7.5Assay Description:Inhibition assay against SARS-CoV 3CL protease, a fluorometric assay was utilized to determine the inhibition constants of the samples.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM11259(dipeptidomimetic unsaturated ester 18a | ethyl (2E...)
Affinity DataKi:  6.44E+3nM ΔG°:  -29.6kJ/mole IC50:  1.00E+4nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM59250(Benzotriazole ester, 18 | acs.jmedchem.1c00409_ST....)
Affinity DataKi:  6.70E+3nMpH: 7.5Assay Description:Inhibition assay against SARS-CoV 3CL protease, a fluorometric assay was utilized to determine the inhibition constants of the samples.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM11262(dipeptidomimetic unsaturated ester 18d | ethyl (2E...)
Affinity DataKi:  9.05E+3nM ΔG°:  -28.8kJ/mole IC50:  1.00E+4nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM11229(AG7088 analogue 2a | CHEMBL20636 | N-[(5-methyliso...)
Affinity DataKi: >1.00E+4nM ΔG°: >-28.5kJ/molepH: 7.5 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using peptide cleavage assay. Cleavage products were resolved and analyzed with a reverse...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM59251(Benzotriazole ester, 19)
Affinity DataKi: >5.00E+4nMpH: 7.5Assay Description:Inhibition assay against SARS-CoV 3CL protease, a fluorometric assay was utilized to determine the inhibition constants of the samples.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM59252(Benzotriazole ester, 20)
Affinity DataKi: >5.00E+4nMpH: 7.5Assay Description:Inhibition assay against SARS-CoV 3CL protease, a fluorometric assay was utilized to determine the inhibition constants of the samples.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM11292(1,5-dichloro-2-{[2,6-dinitro-4-(trifluoromethyl)be...)
Affinity DataIC50:  300nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM11293(4-({4-[(2,3,3-trichloroprop-2-enoyl)oxy]benzene}su...)
Affinity DataIC50:  900nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM11264(N-(3,5-dichlorophenyl)-2-{[4-(2-phenyl-1,3-thiazol...)
Affinity DataIC50:  3.00E+3nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM11294(5-[(4-chlorobenzene)sulfonyl]pyrimidine-2,4-diamin...)
Affinity DataIC50:  6.00E+3nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM11265(N-(4-chlorophenyl)-2-[(4-{5-[1-methyl-5-(trifluoro...)
Affinity DataIC50:  1.00E+4nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM11235(Anilide Inhibitor 3d | tert-butyl N-[(1S)-1-{[(1S)...)
Affinity DataIC50: >1.00E+4nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM11256(AG7088 analogue 4b | ethyl (2E,4S)-4-[(2S)-2-[(2S)...)
Affinity DataIC50:  1.10E+4nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM11258(AG7088 analogue 4d | ethyl (2E,4S)-4-[(2S)-2-[(2S)...)
Affinity DataIC50:  1.10E+4nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM11266(N-(4-chlorophenyl)-2-({4-[4-methyl-5-(4-methyl-1,3...)
Affinity DataIC50:  1.10E+4nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM11267(N-(2-chlorophenyl)-2-({4-[4-methyl-5-(4-methyl-1,3...)
Affinity DataIC50:  1.20E+4nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM11295(1-[(4-chlorobenzene)sulfonyl]-2-nitro-4-(trifluoro...)
Affinity DataIC50:  1.20E+4nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM11253(AG7088 analogue 3c | ethyl (2E,4S)-4-[(2R,5S)-2-be...)
Affinity DataIC50:  1.30E+4nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM11297(4,6-dimethyl-2-[(4-methylbenzene)sulfonyl]-5-nitro...)
Affinity DataIC50:  1.30E+4nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM11296(2-(benzenesulfonyl)-4,6-dimethyl-5-nitropyridine-3...)
Affinity DataIC50:  1.30E+4nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM11268(N-(4-chlorophenyl)-2-({4-[2-(2-methyl-1,3-thiazol-...)
Affinity DataIC50:  1.40E+4nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Academia Sinica

LigandPNGBDBM11271(N-(4-chlorophenyl)-2-({4-[3-(2-chlorophenyl)-1,2-o...)
Affinity DataIC50:  1.50E+4nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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