Compile Data Set for Download or QSAR
Report error Found 28 of ph data with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4D'
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
University of North Carolina at Chapel Hill

LigandChemical structure of BindingDB Monomer ID 14359BDBM14359(3-[(2S)-2-[3-cyclopropoxy-4-(difluoromethoxy)pheny...)
Affinity DataIC50: 0.400nMpH: 7.5 T: 2°CAssay Description:PDE4 catalytic activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using PDE-SPA kit (Amersham International). [3H]-AMP was c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
University of North Carolina at Chapel Hill

LigandChemical structure of BindingDB Monomer ID 187126BDBM187126(US9670181, 6 4-(dibenzo[b,d]furan-2-ylmethyl)-1-et...)
Affinity DataIC50: 0.900nMpH: 7.4 T: 2°CAssay Description:The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
US Patent

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
University of North Carolina at Chapel Hill

LigandChemical structure of BindingDB Monomer ID 30129BDBM30129(phthalazinone, 22)
Affinity DataKi:  1.20nM ΔG°:  -52.5kJ/molepH: 8.0 T: 2°CAssay Description:The samples were assayed in a solution composed of PDE4, [3H]cAMP/cAMP, and test compounds. To convert AMP to adenosine, snake venom was added to eac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
University of North Carolina at Chapel Hill

LigandChemical structure of BindingDB Monomer ID 30128BDBM30128(phthalazinone, 21)
Affinity DataKi:  2nM ΔG°:  -51.1kJ/molepH: 8.0 T: 2°CAssay Description:The samples were assayed in a solution composed of PDE4, [3H]cAMP/cAMP, and test compounds. To convert AMP to adenosine, snake venom was added to eac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
University of North Carolina at Chapel Hill

LigandChemical structure of BindingDB Monomer ID 30127BDBM30127(CHEMBL480988 | phthalazinone, 20)
Affinity DataKi:  2.30nM ΔG°:  -50.8kJ/molepH: 8.0 T: 2°CAssay Description:The samples were assayed in a solution composed of PDE4, [3H]cAMP/cAMP, and test compounds. To convert AMP to adenosine, snake venom was added to eac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
University of North Carolina at Chapel Hill

LigandChemical structure of BindingDB Monomer ID 30126BDBM30126(CHEMBL313041 | phthalazinone, 19)
Affinity DataKi:  6.30nM ΔG°:  -48.2kJ/molepH: 8.0 T: 2°CAssay Description:The samples were assayed in a solution composed of PDE4, [3H]cAMP/cAMP, and test compounds. To convert AMP to adenosine, snake venom was added to eac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
University of North Carolina at Chapel Hill

LigandChemical structure of BindingDB Monomer ID 14360BDBM14360((R)-(-)-3-{2-[(3-cyclopropyloxy-4-difluromethoxy)p...)
Affinity DataIC50: 43nMpH: 7.5 T: 2°CAssay Description:PDE4 catalytic activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using PDE-SPA kit (Amersham International). [3H]-AMP was c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
University of North Carolina at Chapel Hill

LigandChemical structure of BindingDB Monomer ID 14361BDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataKi:  58.9nM ΔG°:  -42.5kJ/molepH: 8.0 T: 2°CAssay Description:The samples were assayed in a solution composed of PDE4, [3H]cAMP/cAMP, and test compounds. To convert AMP to adenosine, snake venom was added to eac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
University of North Carolina at Chapel Hill

LigandChemical structure of BindingDB Monomer ID 187151BDBM187151(US9670181, 31 1-ethyl-6,7-dimethoxy-4-((7-methoxyq...)
Affinity DataIC50: 82nMpH: 7.4 T: 2°CAssay Description:The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
US Patent

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
University of North Carolina at Chapel Hill

LigandChemical structure of BindingDB Monomer ID 31647BDBM31647(tetrahydrobenzothiophene (THBT), 21)
Affinity DataIC50: 126nMpH: 7.5 T: 2°CAssay Description:Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
University of North Carolina at Chapel Hill

LigandChemical structure of BindingDB Monomer ID 31648BDBM31648(tetrahydrobenzothiophene (THBT), 22)
Affinity DataIC50: 126nMpH: 7.5 T: 2°CAssay Description:Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
University of North Carolina at Chapel Hill

LigandChemical structure of BindingDB Monomer ID 187172BDBM187172(US9670181, 51 1-isopropyl-6,7-dimethoxy-4-((6-meth...)
Affinity DataIC50: 280nMpH: 7.4 T: 2°CAssay Description:The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
US Patent

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
University of North Carolina at Chapel Hill

LigandChemical structure of BindingDB Monomer ID 31636BDBM31636(tetrahydrobenzothiophene (THBT), 4)
Affinity DataIC50: 316nMpH: 7.5 T: 2°CAssay Description:Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
University of North Carolina at Chapel Hill

LigandChemical structure of BindingDB Monomer ID 31644BDBM31644(tetrahydrobenzothiophene (THBT), 23)
Affinity DataIC50: 398nMpH: 7.5 T: 2°CAssay Description:Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
University of North Carolina at Chapel Hill

LigandChemical structure of BindingDB Monomer ID 14769BDBM14769(6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...)
Affinity DataIC50: 500nMpH: 7.5 T: 2°CAssay Description:Enzymatic activities were assayed using [3H] cAMP and [3H]cGMP as substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
University of North Carolina at Chapel Hill

LigandChemical structure of BindingDB Monomer ID 31637BDBM31637(tetrahydrobenzothiophene (THBT), 6)
Affinity DataIC50: 501nMpH: 7.5 T: 2°CAssay Description:Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
University of North Carolina at Chapel Hill

LigandChemical structure of BindingDB Monomer ID 31650BDBM31650(tetrahydrobenzothiophene (THBT), 25)
Affinity DataIC50: 1.59E+3nMpH: 7.5 T: 2°CAssay Description:Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
University of North Carolina at Chapel Hill

LigandChemical structure of BindingDB Monomer ID 50020875BDBM50020875(1-Ethyl-4-(N'-isopropylidene-hydrazino)-1H-pyrazol...)
Affinity DataIC50: 2.00E+3nMpH: 7.5 T: 2°CAssay Description:Enzymatic activities were assayed using [3H] cAMP and [3H]cGMP as substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2012
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
University of North Carolina at Chapel Hill

LigandChemical structure of BindingDB Monomer ID 92337BDBM92337(Ro20-1724)
Affinity DataIC50: 2.00E+3nMpH: 7.5 T: 2°CAssay Description:Enzymatic activities were assayed using [3H] cAMP and [3H]cGMP as substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2012
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
University of North Carolina at Chapel Hill

LigandChemical structure of BindingDB Monomer ID 14361BDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataIC50: 2.00E+3nMpH: 7.5 T: 2°CAssay Description:Enzymatic activities were assayed using [3H] cAMP and [3H]cGMP as substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
University of North Carolina at Chapel Hill

LigandChemical structure of BindingDB Monomer ID 31651BDBM31651(tetrahydrobenzothiophene (THBT), 18)
Affinity DataIC50: 2.51E+3nMpH: 7.5 T: 2°CAssay Description:Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
University of North Carolina at Chapel Hill

LigandChemical structure of BindingDB Monomer ID 31640BDBM31640(tetrahydrobenzothiophene (THBT), 14)
Affinity DataIC50: 2.51E+3nMpH: 7.5 T: 2°CAssay Description:Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
University of North Carolina at Chapel Hill

LigandChemical structure of BindingDB Monomer ID 31641BDBM31641(tetrahydrobenzothiophene (THBT), 15)
Affinity DataIC50: 2.51E+3nMpH: 7.5 T: 2°CAssay Description:Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
University of North Carolina at Chapel Hill

LigandChemical structure of BindingDB Monomer ID 31649BDBM31649(tetrahydrobenzothiophene (THBT), 24)
Affinity DataIC50: 2.51E+3nMpH: 7.5 T: 2°CAssay Description:Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
University of North Carolina at Chapel Hill

LigandChemical structure of BindingDB Monomer ID 31642BDBM31642(tetrahydrobenzothiophene (THBT), 16)
Affinity DataIC50: 6.31E+3nMpH: 7.5 T: 2°CAssay Description:Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
University of North Carolina at Chapel Hill

LigandChemical structure of BindingDB Monomer ID 31645BDBM31645(tetrahydrobenzothiophene (THBT), 19)
Affinity DataIC50: 6.31E+3nMpH: 7.5 T: 2°CAssay Description:Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
University of North Carolina at Chapel Hill

LigandChemical structure of BindingDB Monomer ID 31646BDBM31646(tetrahydrobenzothiophene (THBT), 20)
Affinity DataIC50: 6.31E+3nMpH: 7.5 T: 2°CAssay Description:Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
University of North Carolina at Chapel Hill

LigandChemical structure of BindingDB Monomer ID 31643BDBM31643(tetrahydrobenzothiophene (THBT), 17)
Affinity DataIC50: 3.16E+4nMpH: 7.5 T: 2°CAssay Description:Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2009
Entry Details Article
PubMed