Affinity DataKi: 173nMAssay Description:Competitive inhibition of HDAC8 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 396nMAssay Description:Inhibition of human recombinant HDAC8 using fluorescent acetylated substrateMore data for this Ligand-Target Pair
Affinity DataKi: 480nMAssay Description:Inhibition of human recombinant HDAC8 by Michaelis-Menten equation analysisMore data for this Ligand-Target Pair
Affinity DataKi: 480nMAssay Description:The compound was tested in vitro for binding activity against M1 muscarinic receptor in homogenates of the cerebral cortex of rat using [3H]pirenzepi...More data for this Ligand-Target Pair
Affinity DataKi: 700nMAssay Description:Inhibition of human recombinant HDAC8 using [Ac-Leu-Gly-Lys(Ac)-AMC substrate incubated for 15 to 30 minsMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+3nM ΔG°: -32.2kJ/molepH: 7.4 T: 2°CAssay Description:To assess the effect of test compounds on histone deacetylase enzyme function in Vitro, a fluorometric assay was performed using HDAC, which incubate...More data for this Ligand-Target Pair
Affinity DataKi: 2.47E+3nMAssay Description:Inhibition of HDAC in human Hela cells nuclear extracts by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:Inhibition of full length human recombinant HDAC8 expressed in baculovirus infected insect S9 cells using Ac-Leu-GlyLys(Tfa)-AMC as substrate after 3...More data for this Ligand-Target Pair
Affinity DataIC50: 8.80nMAssay Description:Inhibition of recombinant C-terminal His-tagged full length human HDAC8 expressed in baculovirus infected insect Sf9 cells using fluorogenic HDAC cla...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibitory activity against Histone deacetylase (HDAC) in K 562 erythroleukemia cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibitory activity against Beta Glucosidase from AlmondsMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using Ac-Leu-Gly-Lys (Ac)-AMC as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extracts preincubated for 15 mins followed by addition of Fluor de Lys as substrate for 1 hr by fluorom...More data for this Ligand-Target Pair
Affinity DataIC50: 45nMAssay Description:Inhibition of human HDAC8More data for this Ligand-Target Pair
Affinity DataIC50: 53nMAssay Description:Inhibition of HDAC in human HeLa cell extract using Fluor deLys as substrate by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using Boc-Lys(Ac)-AMC as substrate preincubated for 15 mins followed by substrate addition meas...More data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:Inhibition of HDAC in human HeLa nuclear extract using Boc-Lys-(Ac)-AMC as substrate preincubated for 15 mins followed by substrate addition measured...More data for this Ligand-Target Pair
Affinity DataIC50: 65nMAssay Description:Inhibition of human HDAC in HeLa cells by flour de lys assayMore data for this Ligand-Target Pair
Affinity DataIC50: 65nMAssay Description:Inhibition of HDAC in human HeLa cells using Fluor-de-Lys as substrate after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 65nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extracts after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 67nMAssay Description:Inhibition of HDAC in human HeLa cells using Ac-Arg-Gly-Lys(Ac)-AMC as fluorescent substrate after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 67nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extracts using Ac-Arg-Gly-Lys(Ac)-AMC substrate by fluorimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 79nMAssay Description:Inhibition of HDAC in human HeLa cells by fluorescent activity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 79nMAssay Description:Inhibition of HDAC in human HeLa cell extracts using Fluor de Lys as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 79nMAssay Description:Inhibition of HDAC in human HeLa cell extract assessed as fluorophore release by fluorescence spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibition of human HDAC in HeLa cells by fluorescent activity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 90nMAssay Description:Inhibition of HDAC by fluorescent assayMore data for this Ligand-Target Pair
Affinity DataIC50: 99nMAssay Description:Inhibition of HDAC in human HeLa nuclear extract using Ac-Lys(Ac)-pNA as substrate measured after 30 mins by fluorometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of HDAC in human HeLa cells extracts after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of Histone deacetylase (HDAC)of HeLa nuclear extractsMore data for this Ligand-Target Pair
Affinity DataIC50: 102nMAssay Description:Inhibition of HDAC in human HeLa cells nuclear extract using Fluor de lys as substrate after 15 mins by fluorometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 105nMAssay Description:Inhibition of HDAC (unknown origin) using Fluor de Lys substrate after 2 hrs by microplate readerMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of HDAC in HeLa cells by fluorescent activity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of HeLa cell HDACMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of HDAC in HeLa cell lysatesMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using Fluor de Lys as substrate incubated with compound for 30 mins by microtiter-plate reading...More data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of human HDAC8 pre-incubated for 30 mins before substrate addition and measured after 30 mins by HDAC-Glo I/II assayMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Histone Deacetylase (HDAC) Inhibition Assay using Boc-Lys(Ac)-AMC Substrate: Inhibition of HDAC has been implicated to modulate transcription and to ...More data for this Ligand-Target Pair
Affinity DataIC50: 119nMAssay Description:Inhibition of HDAC8 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of human HDAC after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Concentration required to inhibit Histone Deacetylase (HDAC) from K562 erythroleukemia cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 122nMAssay Description:Inhibition of HDAC in human HeLa cells using Fluor de Lys as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using fluorogenic Boc-Lys(acetyl)-AMC as substrate preincubated for 5 mins followed by substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of HDAC in human HeLa cell extract using fluor de Lys as substrate after 15 mins by fluorometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 131nMAssay Description:In brief, 10 μL of HeLa nuclear extract was mixed with various concentrations of target compounds (50 μL), SAHA, using 100% and none HDACs ...More data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of HDAC in HeLa cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 141nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extracts using Fluor de Lys as substrate by fluorescence assayMore data for this Ligand-Target Pair
