Compile Data Set for Download or QSAR
maximum 50k data
Found 23 of affinity data with PDB=2PVW
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM17759((2S)-2-(phosphonomethyl)pentanedioic acid | (S)-2-...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity to NAALADaseMore data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM17659((R,S)-2-phosphonomethylpentanedioic acid | 2-(phos...)
Affinity DataKi:  0.200nMAssay Description:Concentration of the compound required for the neuroprotective effect determined by inhibition of GCP IIMore data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM17659((R,S)-2-phosphonomethylpentanedioic acid | 2-(phos...)
Affinity DataKi:  0.200nMAssay Description:In vitro inhibitory activity against glutamate carboxypeptidase II (GCP II) using N-acetyl-L-aspartyl-[3H]-L-glutamate as a substrateMore data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17659((R,S)-2-phosphonomethylpentanedioic acid | 2-(phos...)
Affinity DataKi:  0.275nMAssay Description:Compound was tested for inhibition of the Folate hydrolaseMore data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM17659((R,S)-2-phosphonomethylpentanedioic acid | 2-(phos...)
Affinity DataKi:  0.280nMAssay Description:Inhibition of antiTEV-tagged GCP2 extracellular portion (aa 44-750) (unknown origin) using folyl-di-L-glutamate as substrate by HPLC-based enzymatic ...More data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM17659((R,S)-2-phosphonomethylpentanedioic acid | 2-(phos...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to NAALADaseMore data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM17659((R,S)-2-phosphonomethylpentanedioic acid | 2-(phos...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of NAALADase activity in human LNCaP cell membranes assessed as inhibition of [3H]NAG conversion to [3H]glutamate after 30 mins by liquid ...More data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM17659((R,S)-2-phosphonomethylpentanedioic acid | 2-(phos...)
Affinity DataKi:  31nMAssay Description:Displacement of [123I]-DCIT from PSMA in human LNCaP cells after 1 hr by gamma countingMore data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17759((2S)-2-(phosphonomethyl)pentanedioic acid | (S)-2-...)
Affinity DataIC50:  0.100nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM17659((R,S)-2-phosphonomethylpentanedioic acid | 2-(phos...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human recombinant NAALADaseMore data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM17659((R,S)-2-phosphonomethylpentanedioic acid | 2-(phos...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of GCP-2 (unknown origin)More data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM17659((R,S)-2-phosphonomethylpentanedioic acid | 2-(phos...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of N-acetyl-L-aspartyl-[3H]-L-glutamate binding to glutamate carboxypeptidase II (GCP II)More data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17659((R,S)-2-phosphonomethylpentanedioic acid | 2-(phos...)
Affinity DataIC50:  0.300nMAssay Description:Inhibitory concentration against rat brain NAALADase (Folate hydrolase)More data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM17659((R,S)-2-phosphonomethylpentanedioic acid | 2-(phos...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of Glutamate carboxypeptidase IIMore data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17659((R,S)-2-phosphonomethylpentanedioic acid | 2-(phos...)
Affinity DataIC50:  0.300nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17659((R,S)-2-phosphonomethylpentanedioic acid | 2-(phos...)
Affinity DataIC50:  0.300nMpH: 7.4 T: 2°CAssay Description:The inhibition concentration values of GCPII were determined using the radioenzymatic assay with [3H] NAAG (radiolabeled on the terminal glutamate). ...More data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2 [44-750](Homo sapiens (Human))
Guilford Pharmaceuticals

LigandPNGBDBM17659((R,S)-2-phosphonomethylpentanedioic acid | 2-(phos...)
Affinity DataIC50:  0.300nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM17659((R,S)-2-phosphonomethylpentanedioic acid | 2-(phos...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of NAALADase activity in human LNCaP cell membranes assessed as inhibition of [3H]NAG conversion to [3H]glutamate after 30 mins by liquid ...More data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17659((R,S)-2-phosphonomethylpentanedioic acid | 2-(phos...)
Affinity DataIC50:  5.10nMAssay Description:Inhibitory activity of the compound against expressed rat Glutamate carboxypeptidase II, using a substrate concentration of 5 microMMore data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM17659((R,S)-2-phosphonomethylpentanedioic acid | 2-(phos...)
Affinity DataIC50:  52nMAssay Description:Displacement of [125I]23 from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM17659((R,S)-2-phosphonomethylpentanedioic acid | 2-(phos...)
Affinity DataKd:  0.5nMAssay Description:Binding affinity to PSMA in human PC3 cells assessed as cell surface binding in Tris-buffered saline bufferMore data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM17659((R,S)-2-phosphonomethylpentanedioic acid | 2-(phos...)
Affinity DataKd:  0.400nMAssay Description:Binding affinity to PSMA in human LNCaP cells assessed as cell surface binding in Tris-buffered saline bufferMore data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM17659((R,S)-2-phosphonomethylpentanedioic acid | 2-(phos...)
Affinity DataEC50:  0.620nMAssay Description:Concentration of the compound required for the neuroprotective effect determined by inhibition of GCP IIMore data for this Ligand-Target Pair