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Found 28 of affinity data with PDB=3TPP
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

LigandPNGBDBM16034(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataKi:  233nM ΔG°:  -39.4kJ/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

LigandPNGBDBM16034(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50:  10nMAssay Description:Inhibition of BACE1 using methoxycoumarin-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys-dinitrophenyl as substrate preincubated 1 hr before substrate addit...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

LigandPNGBDBM16034(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50:  10nMpH: 4.5 T: 2°CAssay Description:For BACE activity assay using recombinant MBP-APP_NFEV substrate, BACE was incubated with purified MBP-APP_NFEV substrate in reaction buffer containi...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

LigandPNGBDBM16034(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human recombinant BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

LigandPNGBDBM16034(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50:  15nMpH: 4.5 T: 2°CAssay Description:The assay was performed using a 96-well format on a HPLC equipped with four 96-well plate holders. Test compounds were preincubated with enzymes for ...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

LigandPNGBDBM16034(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50:  15nMpH: 4.5 T: 2°CAssay Description:The assay was performed using a 96-well format on a HPLC equipped with four 96-well plate holders. Test compounds were preincubated with enzymes for ...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

LigandPNGBDBM16034(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50:  15nMpH: 4.5 T: 2°CAssay Description:The assay was performed using a 96-well format on a HPLC equipped with four 96-well plate holders. Test compounds were preincubated with enzymes for ...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

LigandPNGBDBM16034(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50:  15nMAssay Description:Inhibition of recombinant human BACE1 proteolytic activityMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

LigandPNGBDBM16034(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50:  15nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

LigandPNGBDBM16034(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50:  15nMAssay Description:Inhibition of BACE1 by cell-free FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

LigandPNGBDBM16034(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human BACE1 preincubated for 30 min measured after 30 minsMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

LigandPNGBDBM16034(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50:  15nMAssay Description:Inhibition of BACE1 mediated cleavage of amyloid precursor protein by chemiluminescence assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

LigandPNGBDBM16034(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50:  15nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

LigandPNGBDBM16034(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50:  19.9nMAssay Description:Inhibition of recombinant human BACE1 using Eu-CEVNLDAEFK-Qsy7 as substrate by HTRF assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

LigandPNGBDBM16034(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant BACE1 using M-2420 as substrate preincubated with enzyme for 1 hr by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

LigandPNGBDBM16034(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50:  23nMAssay Description:Inhibition of recombinant human BACE1 (43 to 454 residues) expressed in Escherichia coli BL21(DE3) using Biotin-epsilon-amino-n-capronic acid-SEVNLDA...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

LigandPNGBDBM16034(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50:  25nMAssay Description:Inhibition of BACE1 (unknown origin) after 90 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

LigandPNGBDBM16034(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50:  26nMAssay Description:Inhibition of BACE1 in human SH-SY5Y cells harboring wild-type human beta-APP assessed as reduction in secreted amyloid beta (1 to 40) after 24 hrs b...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

LigandPNGBDBM16034(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50:  29nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in human 293T cellsMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

LigandPNGBDBM16034(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50:  29nMAssay Description:Inhibition of BACE1 expressed in HEK293T cells co-transfected APP with NFEV mutation at proteolytic site by sAPP_NF cell based assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

LigandPNGBDBM16034(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50:  29nMAssay Description:Inhibition of human BACE1 in HEK293T cells transfected with APP695 after 20 to 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

LigandPNGBDBM16034(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50:  45nMAssay Description:Inhibition of recombinant human BACE1 expressed in CHO cells co-transfected with human APP with Swedish mutation assessed as amyloid beta1-40 secreti...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

LigandPNGBDBM16034(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50:  46nMAssay Description:Inhibition of recombinant human BACE1 expressed in baculovirus expression system using Rh-EVNLDAEFK-quencher as substrate after 60 mins by spectroflu...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

LigandPNGBDBM16034(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50:  160nMAssay Description:Inhibition of BACE1 (unknown origin) using peptide substrate by time-course measurement-based fluorescence analysisMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

LigandPNGBDBM16034(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50:  250nMAssay Description:Inhibition of BACE1 in human HEK293 cells transfected with pCDNA-neo-SEAP-APP assessed as secreted alkaline phosphatase after cleavage of beta-site o...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

LigandPNGBDBM16034(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50:  250nMAssay Description:Inhibition of BACE1 by fluorescence assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

LigandPNGBDBM16034(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

LigandPNGBDBM16034(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataEC50:  43nMAssay Description:Inhibition of BACE1 expressed in HEK293T cells co-transfected APP with NFEV mutation at proteolytic site assessed as amyloid EV40 secretionMore data for this Ligand-Target Pair