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Found 4 of affinity data with PDB=4FS4
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226442(2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5...)
Affinity DataIC50:  380nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226442(2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5...)
Affinity DataIC50:  590nMAssay Description:Inhibition of BACE1 by IGEN assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226442(2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5...)
Affinity DataIC50:  670nMAssay Description:Inhibition of BACE1 by SPR assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226442(2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5...)
Affinity DataIC50:  9.10E+4nMAssay Description:Inhibition of human full length BACE1 expressed in HEK293 cellsMore data for this Ligand-Target Pair