Affinity DataIC50: 30nMAssay Description:Displacement of biotinylated ligand from CBP (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 64nMAssay Description:Inhibition of human CREBBP by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 69nMAssay Description:Displacement of biotinylated tetra-acetylated histone H4 from human his-tagged CBP by alphascreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 79nMAssay Description:Inhibition of human CREBBP by AlphaScreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibition of biotinylated-H4KAc4 binding to human His6-tagged CBP (R1081 to G1197 residues) expressed in Escherichia coli BL21(DE3) after 2.5 hrs by...More data for this Ligand-Target Pair
Affinity DataIC50: 125nMAssay Description:Inhibition of His6-tagged human CREBBP (R1081 to G1197 residues) expressed in Escherichia coli BL21(DE3) using biotinylated-H4KAc4 as substrate by Al...More data for this Ligand-Target Pair
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Guangzhou Medical University
Curated by ChEMBL
Guangzhou Medical University
Curated by ChEMBL
Affinity DataIC50: 230nMAssay Description:Inhibition of biotinylated-H4KAc4 binding to human His6-tagged EP300 (A1040 to G1161 residues) expressed in Escherichia coli BL21(DE3) after 2.5 hrs ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of Halo-tagged histone H3.3 binding to NanoLuc luciferase conjugated CBP (unknown origin) expressed in HEK293 cells after overnight incuba...More data for this Ligand-Target Pair
TargetCREB-binding protein/Histone acetyltransferase p300(Homo sapiens (Human))
Genentech
Curated by ChEMBL
Genentech
Curated by ChEMBL
Affinity DataEC50: 6.90E+3nMAssay Description:Inhibition of CBP/EP300 (unknown origin) assessed as reduction in MYC expression by cell based assayMore data for this Ligand-Target Pair
Affinity DataKd: 21nMAssay Description:Binding affinity to human CBP by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
Affinity DataKd: 21nMAssay Description:Binding affinity to human CBP by ITC analysisMore data for this Ligand-Target Pair
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Guangzhou Medical University
Curated by ChEMBL
Guangzhou Medical University
Curated by ChEMBL
Affinity DataKd: 32nMAssay Description:Binding affinity to human p300 by ITC analysisMore data for this Ligand-Target Pair
Affinity DataKd: 21nMAssay Description:Experiments were performed using recombinant CBP and BRD4 bromodomainsusing the procedure reported recently (Hett et al., 2015).More data for this Ligand-Target Pair
TargetCREB-binding protein/Histone acetyltransferase p300(Homo sapiens (Human))
Genentech
Curated by ChEMBL
Genentech
Curated by ChEMBL
Affinity DataKd: 21nMAssay Description:Binding affinity to human N-terminal His10-tagged/C-terminal Biotin-tagged CBP (R1081 to G1198 residues)/P300 expressed in Escherichia coli BL21(DE3)...More data for this Ligand-Target Pair