Affinity DataKi: 0.251nMAssay Description:Displacement of [3H]granisetron from 5-hydroxytryptamine 3 receptor of rat cortexMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 0.589nMAssay Description:Potency at neuronal 5-hydroxytryptamine 3 receptor in the rabbit heartMore data for this Ligand-Target Pair
Affinity DataKi: 0.590nMAssay Description:Binding affinity for central 5-hydroxytryptamine 3 receptor was determined by displacement of [3H]-ketanserinMore data for this Ligand-Target Pair
Affinity DataKi: 0.780nMAssay Description:Displacement of [3H]- GR-65,630 binding to 5-hydroxytryptamine 3 receptor in rat brain cortical membranesMore data for this Ligand-Target Pair
Affinity DataKi: 1.45nMAssay Description:Displacement of [3H]granisetron from human 5HT3A expressed in HEK293 cells after 1 hr by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 1.45nMAssay Description:Displacement of [3H]granisetron from human 5HT3A receptor expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 3 receptor in rat cortical membranes using [3H]- 1-Methyl-1H-indazole-3-carboxylic acid (8-methyl-8-a...More data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:pKi value for inhibition of [3H]LY-278584 binding to 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.70nMAssay Description:Displacement of the 5-hydroxytryptamine 3 receptor ligand [3H]GR-65630 from rat brain cortical membranes.More data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:In vitro by displacement of [3H]LY-278584 from 5-hydroxytryptamine 3 receptor on rat entorhinal cortexMore data for this Ligand-Target Pair
Affinity DataKi: 2.10nMAssay Description:Compound was evaluated for its ability to displace [3H]quipazine binding to 5-hydroxytryptamine 3 receptor sites in NG 108-15. More data for this Ligand-Target Pair
Affinity DataKi: 3.98nMAssay Description:Binding affinity to 5HT3A receptorMore data for this Ligand-Target Pair
Affinity DataKi: 9.10nMAssay Description:Binding affinity to 5-hydroxytryptamine 3 receptor of neuronal in the afferent rabbit vagusMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity for central 5-hydroxytryptamine 3 receptor was determined by displacement of [3H]GR-65630More data for this Ligand-Target Pair
Affinity DataKi: <1.00E+4nMAssay Description:5-hydroxytryptamine 3 receptor antagonist activity was confirmed by its ability to antagonize 5-HT evoked tachycardia of rabbit isolated heartMore data for this Ligand-Target Pair
Affinity DataIC50: 1.76E+3nMAssay Description:Binding affinity towards 5-HT3 receptor in rat was evaluatedMore data for this Ligand-Target Pair
Affinity DataKd: 0.530nMAssay Description:Binding affinity to human wild type 5-HT3A receptor expressed in HEK293 cells after 24 hrs by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Mus musculus (house mouse))
Merrell Dow Research Institute
Curated by ChEMBL
Merrell Dow Research Institute
Curated by ChEMBL
Affinity DataKd: 1.40nMAssay Description:Binding affinity towards 5-hydroxytryptamine 3 receptor was determined by using [3H]-ICS 205-930 as radioligand in mouse N1E 115 cellsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Mus musculus (house mouse))
Merrell Dow Research Institute
Curated by ChEMBL
Merrell Dow Research Institute
Curated by ChEMBL
Affinity DataKd: 1.30nMAssay Description:Antagonistic activity against Serotonin 5-hydroxytryptamine 3 receptor in isolated rabbit vagus nerve (RVN)More data for this Ligand-Target Pair
Affinity DataEC50: 320nMAssay Description:Agonist activity at human wild type 5-HT3A receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKd: 0.200nMAssay Description:Binding affinity to human wild type 5-HT3A/5-HT3B receptor expressed in HEK293 cells after 24 hrs by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 500nMAssay Description:Agonist activity at human wild type 5-HT3A/5-HT3B receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
