Compile Data Set for Download or QSAR
maximum 50k data
Found 49 of ec50 data for polymerid = 1967,50002166,5482
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)
Affinity DataEC50:  41nMAssay Description:Inhibition of recombinant human HDAC1 expressed in baculovirus expression system using KI-104 as substrate incubated for 3 hrs by by fluorescence-bas...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50134803(5,8-Dimethyl-11-(6-oxiranyl-6-oxo-hexyl)-decahydro...)
Affinity DataEC50:  110nMAssay Description:Inhibition of Histone deacetylase 1 induced acetylated histone in mammalian cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50538663(CHEMBL4642874)
Affinity DataEC50:  200nMAssay Description:Inhibition of HDAC1 in human MM96L cells assessed as activation of histone H4 acetylation at Lys5, Lys8, Lys12 and Lys16 residues by Western blot ana...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50538658(CHEMBL4634521)
Affinity DataEC50:  600nMAssay Description:Inhibition of HDAC1 in human MM96L cells assessed as activation of histone H4 acetylation at Lys5, Lys8, Lys12 and Lys16 residues by Western blot ana...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50134805(6,9-Dibenzyl-12-(6-oxiranyl-6-oxo-hexyl)-decahydro...)
Affinity DataEC50:  820nMAssay Description:Inhibition of Histone deacetylase 1 induced acetylated histone in mammalian cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataEC50:  1.00E+3nMAssay Description:In vitro inhibition of partially purified recombinant human Histone deacetylase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of human HDAC1 assessed as histone H4 acetylation in cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50232653(CHEMBL403467 | N-(2-aminophenyl)-4-((6-methoxybenz...)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of HDAC1 in human T24 cells assessed as induction of histone H4 acetylation after 16 hrs relative to MS-275More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105689((E)-3-[4-(3,4-Dimethoxy-benzenesulfonylamino)-phen...)
Affinity DataEC50:  1.00E+3nMAssay Description:Concentration of compound required for acetylation of histone-4 in human T24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50232652(4-((1H-benzo[d]imidazol-2-ylamino)methyl)-N-(2-ami...)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of HDAC1 in human T24 cells assessed as induction of histone H4 acetylation after 16 hrs relative to MS-275More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50232648(CHEMBL254309 | N-(2-aminophenyl)-4-((6-methoxy-1H-...)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of HDAC1 in human T24 cells assessed as induction of histone H4 acetylation after 16 hrs relative to MS-275More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50232647(CHEMBL254111 | N-(2-aminophenyl)-4-((5-chlorobenzo...)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of HDAC1 in human T24 cells assessed as induction of histone H4 acetylation after 16 hrs relative to MS-275More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50232650(CHEMBL254519 | N-(2-aminophenyl)-4-((6-(2-morpholi...)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of HDAC1 in human T24 cells assessed as induction of histone H4 acetylation after 16 hrs relative to MS-275More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105675((E)-3-[4-(4-Chloro-benzenesulfonylamino)-phenyl]-N...)
Affinity DataEC50:  1.50E+3nMAssay Description:Concentration of compound required for acetylation of histone-4 in human T24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50475233(CHEMBL191091)
Affinity DataEC50:  1.80E+3nMAssay Description:Inhibition of HDAC1 in human MM96L cells assessed as activation of histone H4 acetylation at Lys5, Lys8, Lys12 and Lys16 residues by Western blot ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50134799(6-((5S,8S,11S,13aR)-5,8-Dimethyl-4,7,10,13-tetraox...)
Affinity DataEC50:  1.90E+3nMAssay Description:Inhibition of Histone deacetylase 1 induced acetylated histone in mammalian cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50232654(CHEMBL403695 | N-(2-aminophenyl)-4-((6-(pyridin-3-...)
Affinity DataEC50:  2.00E+3nMAssay Description:Inhibition of HDAC1 in human T24 cells assessed as induction of histone H4 acetylation after 16 hrs relative to MS-275More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50232646(CHEMBL254112 | N-(2-aminophenyl)-4-((6-bromobenzo[...)
Affinity DataEC50:  2.00E+3nMAssay Description:Inhibition of HDAC1 in human T24 cells assessed as induction of histone H4 acetylation after 16 hrs relative to MS-275More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105683((E)-N-Hydroxy-3-[4-(4-trifluoromethoxy-benzenesulf...)
Affinity DataEC50:  2.00E+3nMAssay Description:Concentration of compound required for acetylation of histone-4 in human T24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50232651(CHEMBL253912 | N-(2-aminophenyl)-4-((benzo[d]thiaz...)
Affinity DataEC50:  3.00E+3nMAssay Description:Inhibition of HDAC1 in human T24 cells assessed as induction of histone H4 acetylation after 16 hrs relative to MS-275More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50232649(CHEMBL254310 | N-(2-aminophenyl)-4-((6-(pyridin-2-...)
Affinity DataEC50:  3.00E+3nMAssay Description:Inhibition of HDAC1 in human T24 cells assessed as induction of histone H4 acetylation after 16 hrs relative to MS-275More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50232658(CHEMBL254311 | N-(2-aminophenyl)-4-((6-(2-morpholi...)
Affinity DataEC50:  5.00E+3nMAssay Description:Inhibition of HDAC1 in human T24 cells assessed as induction of histone H4 acetylation after 16 hrs relative to MS-275More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105678((E)-N-Hydroxy-3-[4-(4-methoxy-benzenesulfonylamino...)
Affinity DataEC50:  5.00E+3nMAssay Description:Concentration of compound required for acetylation of histone-4 in human T24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105696((E)-3-[4-(3,4-Dichloro-benzenesulfonylamino)-pheny...)
Affinity DataEC50:  5.00E+3nMAssay Description:Concentration of compound required for acetylation of histone-4 in human T24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105684(3-(4-Benzenesulfonylamino-phenyl)-N-hydroxy-propio...)
Affinity DataEC50:  5.00E+3nMAssay Description:Concentration of compound required for acetylation of histone-4 in human T24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105682(4-Benzenesulfonylamino-N-hydroxy-benzamide | CHEMB...)
Affinity DataEC50:  5.00E+3nMAssay Description:In vitro inhibition of partially purified recombinant human Histone deacetylase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105692((E)-3-[4-(4-tert-Butyl-benzenesulfonylamino)-pheny...)
Affinity DataEC50:  5.00E+3nMAssay Description:In vitro inhibition of partially purified recombinant human Histone deacetylase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105691((E)-3-(4-Benzenesulfonylamino-phenyl)-N-hydroxy-ac...)
Affinity DataEC50:  5.00E+3nMAssay Description:In vitro inhibition of partially purified recombinant human Histone deacetylase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50372440(CHEMBL260957)
Affinity DataEC50:  5.00E+3nMAssay Description:Inhibition of human HDAC1 assessed as histone H4 acetylation in cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataEC50:  6.00E+3nMAssay Description:Inhibition of Histone deacetylase 1 induced acetylated histone in mammalian cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50246033(2,2,2-Trifluoro-1-(5-{3-[(methylsulfonyl)methyl]-1...)
Affinity DataEC50:  9.00E+3nMAssay Description:Inhibition of HDAC1 in human HCT116 cells assessed as inhibition of histone-H3 deacetylation after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50372442(CHEMBL260740)
Affinity DataEC50:  1.00E+4nMAssay Description:Inhibition of human HDAC1 assessed as histone H4 acetylation in cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105677((E)-N-Hydroxy-3-[4-(toluene-4-sulfonylamino)-pheny...)
Affinity DataEC50:  1.00E+4nMAssay Description:Concentration of compound required for acetylation of histone-4 in human T24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105686((E)-N-Hydroxy-3-[4-(toluene-3-sulfonylamino)-pheny...)
Affinity DataEC50:  1.20E+4nMAssay Description:Concentration of compound required for acetylation of histone-4 in human T24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105679((E)-N-Hydroxy-3-[4-(4-nitro-benzenesulfonylamino)-...)
Affinity DataEC50:  2.00E+4nMAssay Description:Concentration of compound required for acetylation of histone-4 in human T24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105688((E)-N-Hydroxy-3-[4-(3-trifluoromethyl-benzenesulfo...)
Affinity DataEC50:  2.20E+4nMAssay Description:Concentration of compound required for acetylation of histone-4 in human T24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105680(3-(4-Benzenesulfonylamino-phenyl)-N-hydroxy-2-meth...)
Affinity DataEC50: >2.50E+4nMAssay Description:Concentration of compound required for acetylation of histone-4 in human T24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105690(2-(4-Benzenesulfonylamino-phenyl)-N-hydroxy-acetam...)
Affinity DataEC50: >2.50E+4nMAssay Description:Concentration of compound required for acetylation of histone-4 in human T24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105693((E)-N-Hydroxy-3-[4-(4-sulfamoyl-benzenesulfonylami...)
Affinity DataEC50: >2.50E+4nMAssay Description:Concentration of compound required for acetylation of histone-4 in human T24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105687((E)-N-Hydroxy-3-[4-(2,4,5-triisopropyl-benzenesulf...)
Affinity DataEC50: >2.50E+4nMAssay Description:In vitro inhibition of partially purified recombinant human Histone deacetylase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105685((E)-3-[4-(Benzenesulfonyl-methyl-amino)-phenyl]-N-...)
Affinity DataEC50: >2.50E+4nMAssay Description:Concentration of compound required for acetylation of histone-4 in human T24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105694(4-(4-Benzenesulfonylamino-phenyl)-N-hydroxy-butyra...)
Affinity DataEC50: >2.50E+4nMAssay Description:In vitro inhibition of partially purified recombinant human Histone deacetylase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105681((E)-3-[4-(2,4-Dichloro-benzenesulfonylamino)-pheny...)
Affinity DataEC50: >2.50E+4nMAssay Description:Concentration of compound required for acetylation of histone-4 in human T24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50372441(CHEMBL260958)
Affinity DataEC50:  2.50E+4nMAssay Description:Inhibition of human HDAC1 assessed as histone H4 acetylation in cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105695((E)-3-(4-Benzenesulfonylamino-phenyl)-N-hydroxy-2-...)
Affinity DataEC50: >2.50E+4nMAssay Description:Concentration of compound required for acetylation of histone-4 in human T24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105676(2-(4-Benzenesulfonylamino-benzyl)-N-hydroxy-3-meth...)
Affinity DataEC50: >2.50E+4nMAssay Description:Concentration of compound required for acetylation of histone-4 in human T24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50354086(FK-228 | Istodax | ROMIDEPSIN)
Affinity DataEC50:  3.60E+4nMAssay Description:Inhibition of Histone deacetylase 1 induced acetylated histone in mammalian cells.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50300003(3-[5-(Trifluoroacetyl)thiophen-2-yl]benzoic Acid |...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of HDAC1 in human HCT116 cells assessed as inhibition of histone-H3 deacetylation after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM22449(CHEMBL356769 | N-(4-{(2R,4R,6S)-4-{[(4,5-diphenyl-...)
Affinity DataEC50:  2.17E+5nMAssay Description:Inhibition of Histone deacetylase 1 induced acetylated histone in mammalian cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed