Affinity DataEC50: 0.100nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
Affinity DataEC50: 0.126nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
Affinity DataEC50: 0.158nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
Affinity DataEC50: 0.200nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
Affinity DataEC50: 0.200nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
Affinity DataEC50: 0.200nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
Affinity DataEC50: 0.200nMAssay Description:Agonist activity at recombinant human GST-tagged FXR ligand binding domain (193 to 472 residues) expressed in baculovirus infected insect cells asses...More data for this Ligand-Target Pair
Affinity DataEC50: 0.251nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
Affinity DataEC50: 0.251nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
Affinity DataEC50: 0.251nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
Affinity DataEC50: 0.260nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells assessed as BSEP promoter driven cellular transcriptional activity after 24 hrs by luciferas...More data for this Ligand-Target Pair
Affinity DataEC50: 0.270nMAssay Description:Agonist activity at recombinant human GST-tagged FXR ligand binding domain (193 to 472 residues) expressed in baculovirus infected insect cells asses...More data for this Ligand-Target Pair
Affinity DataEC50: 0.300nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.316nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
Affinity DataEC50: 0.398nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
Affinity DataEC50: 0.398nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
Affinity DataEC50: 0.398nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
Affinity DataEC50: 0.398nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
Affinity DataEC50: 0.398nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
Affinity DataEC50: 0.398nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
Affinity DataEC50: 0.398nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
Affinity DataEC50: 0.398nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
Affinity DataEC50: 0.400nMAssay Description:Inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
Affinity DataEC50: 0.400nMAssay Description:Agonist activity at human FXR expressed in HEK293 cells measured after 18 hrs by steady-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.420nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells assessed as BSEP promoter driven cellular transcriptional activity after 24 hrs by luciferas...More data for this Ligand-Target Pair
Affinity DataEC50: 0.460nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells assessed as BSEP promoter driven cellular transcriptional activity after 24 hrs by luciferas...More data for this Ligand-Target Pair
Affinity DataEC50: 0.490nMAssay Description:Agonist activity at recombinant human GST-tagged FXR ligand binding domain (193 to 472 residues) expressed in baculovirus infected insect cells asses...More data for this Ligand-Target Pair
Affinity DataEC50: 0.5nMAssay Description:Agonist activity at GST-tagged human FXR-LBD (193 to 472 residues) using biotinylated SRC-1 peptide as substrate incubated for 1 hrs by HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.5nMAssay Description:Agonist activity at human FXR expressed in HEK293 cells measured after 18 hrs by steady-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.501nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
Affinity DataEC50: 0.501nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
Affinity DataEC50: 0.520nMAssay Description:Agonist activity at human FXR expressed in human HuH7 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.540nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells assessed as BSEP promoter driven cellular transcriptional activity after 24 hrs by luciferas...More data for this Ligand-Target Pair
Affinity DataEC50: 0.540nMAssay Description:Agonist activity at recombinant human GST-tagged FXR ligand binding domain (193 to 472 residues) expressed in baculovirus infected insect cells asses...More data for this Ligand-Target Pair
Affinity DataEC50: 0.570nMAssay Description:Agonist activity at recombinant human GST-tagged FXR ligand binding domain (193 to 472 residues) expressed in baculovirus infected insect cells asses...More data for this Ligand-Target Pair
Affinity DataEC50: 0.631nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
Affinity DataEC50: 0.631nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
Affinity DataEC50: 0.631nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
Affinity DataEC50: 0.631nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
Affinity DataEC50: 0.631nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
Affinity DataEC50: 0.690nMAssay Description:Agonist activity at recombinant human GST-tagged FXR ligand binding domain (193 to 472 residues) expressed in baculovirus infected insect cells asses...More data for this Ligand-Target Pair
Affinity DataEC50: 0.700nMAssay Description:Agonist activity at FXR transfected in human HEK293T cells o-expressing pGL3/hBSEP/luc incubated for 24 hrs by Steady-Glo reagent based luciferase re...More data for this Ligand-Target Pair
Affinity DataEC50: 0.700nMAssay Description:Agonist activity at human FXR expressed in HEK293 cells measured after 18 hrs by steady-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.794nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
Affinity DataEC50: 0.794nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
Affinity DataEC50: 0.794nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
Affinity DataEC50: 0.800nMAssay Description:Agonist activity at recombinant human GST-tagged FXR ligand binding domain (193 to 472 residues) expressed in baculovirus infected insect cells asses...More data for this Ligand-Target Pair
Affinity DataEC50: 0.800nMAssay Description:Agonist activity at human FXR expressed in human HuH7 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.820nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells assessed as BSEP promoter driven cellular transcriptional activity after 24 hrs by luciferas...More data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:A Gal4-hFXR fusion construct reporter system was used as the primary assay to characterize compound activity. A construct including 5 copies of the G...More data for this Ligand-Target Pair