Compile Data Set for Download or QSAR
maximum 50k data
Found 112 of ec50 data for polymerid = 2259
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50172379((8E,10E)-(5S,9R)-20,20,20-Trifluoro-5,12-dihydroxy...)
Affinity DataEC50:  3nMAssay Description:Effective concentration required to inhibit 5-lipoxygenase by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50172379((8E,10E)-(5S,9R)-20,20,20-Trifluoro-5,12-dihydroxy...)
Affinity DataEC50:  3nMAssay Description:Effective concentration required to inhibit 5-lipoxygenase by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50001176(2-(5-Chloro-benzothiazol-2-ylsulfanyl)-ethylamine-...)
Affinity DataEC50:  20nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50001187(3-(5-Chloro-benzothiazol-2-ylsulfanyl)-N-hydroxy-N...)
Affinity DataEC50:  20nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50001181(3-(Benzothiazol-2-ylsulfanyl)-N-hydroxy-N-methyl-p...)
Affinity DataEC50:  39nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50001171(3-(Benzothiazol-2-ylsulfanyl)-propylamine-N-hydrox...)
Affinity DataEC50:  45nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50001183(3-[5-(4-Chloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyr...)
Affinity DataEC50:  70nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50001182(2-(5-Chloro-benzothiazol-2-ylsulfanyl)-ethylamine-...)
Affinity DataEC50:  70nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50001180(2-(Benzothiazol-2-ylsulfanyl)-N-hydroxy-N-methyl-a...)
Affinity DataEC50:  70nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50001168(3-(Benzothiazol-2-ylsulfanyl)-propylamine-N-hydrox...)
Affinity DataEC50:  70nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50001169(2-benzo[d][1,3]thiazol-2-ylsulfanyl-1-ethanamino-N...)
Affinity DataEC50:  90nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50001170(5-ethyloxy-2-benzo[d][1,3]thiazol-2-ylsulfanyl-1-e...)
Affinity DataEC50:  110nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50001172(2-benzo[d][1,3]thiazol-2-ylsulfanyl-1-ethanamino-N...)
Affinity DataEC50:  130nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50001179(3-(Benzothiazol-2-ylsulfanyl)-N-hydroxy-N-methyl-a...)
Affinity DataEC50:  130nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50001184(2-(6-Isopropyl-benzothiazol-2-ylsulfanyl)-ethylami...)
Affinity DataEC50:  160nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM31122(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11a)
Affinity DataIC50:  86nM EC50:  230nMpH: 7.4 T: 2°CAssay Description:For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM31133(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11l)
Affinity DataIC50:  67nM EC50:  320nMAssay Description:For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM31125(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11d)
Affinity DataIC50:  140nM EC50:  340nMpH: 7.4 T: 2°CAssay Description:For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM31138(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11q)
Affinity DataIC50:  130nM EC50:  350nMAssay Description:For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50001177(2-(6-Ethoxy-benzothiazol-2-ylsulfanyl)-ethylamine-...)
Affinity DataEC50:  390nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM31136(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11o)
Affinity DataIC50:  130nM EC50:  440nMAssay Description:For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM31127(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11f)
Affinity DataIC50:  150nM EC50:  450nMpH: 7.4 T: 2°CAssay Description:For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50000541((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Affinity DataEC50:  470nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM31139(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11r)
Affinity DataIC50:  170nM EC50:  480nMAssay Description:For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM31134(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11m)
Affinity DataIC50:  31nM EC50:  490nMAssay Description:For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM31126(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11e)
Affinity DataIC50:  96nM EC50:  500nMpH: 7.4 T: 2°CAssay Description:For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM31129(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11h)
Affinity DataIC50:  130nM EC50:  520nMpH: 7.4 T: 2°CAssay Description:For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM31132(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11k)
Affinity DataIC50:  45nM EC50:  520nMpH: 7.4 T: 2°CAssay Description:For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50001178(2-(7-Chloro-benzothiazol-2-ylsulfanyl)-ethylamine-...)
Affinity DataEC50:  530nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM31128(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11g)
Affinity DataIC50:  95nM EC50:  600nMpH: 7.4 T: 2°CAssay Description:For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM24561(CHEMBL459722 | Pirinixic acid-based compound, 6d |...)
Affinity DataIC50:  1.90E+4nM EC50:  600nMpH: 7.4 T: 2°CAssay Description:For determination of the activity of 5-LO in 100000g supernatants, aliquots of the supernatants were added to reaction mix, and were preincubated wit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM31130(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11i)
Affinity DataIC50:  150nM EC50:  650nMpH: 7.4 T: 2°CAssay Description:For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM31115(5-hydroxy-1H-indole-3-carboxylate, 10c)
Affinity DataIC50:  1.20E+3nM EC50:  700nMpH: 7.4 T: 2°CAssay Description:For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM31121(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 14)
Affinity DataIC50:  240nM EC50:  710nMpH: 7.4 T: 2°CAssay Description:For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50001175(C-(Benzothiazol-2-ylsulfanyl)-methylamine-N-hydrox...)
Affinity DataEC50:  1.07E+3nMAssay Description:In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM24559(Pirinixic acid-based compound, 5b | ethyl 2-{[4-ch...)
Affinity DataEC50:  1.10E+3nMpH: 7.4 T: 2°CAssay Description:For assays of intact cells, 5000,000 freshly isolated PMNL cells were resuspended in PGC buffer. After preincubation with the test compounds for 15 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM24558(Pirinixic acid-based compound, 4d | ethyl 2-{[4-ch...)
Affinity DataEC50:  1.20E+3nMpH: 7.4 T: 2°CAssay Description:For assays of intact cells, 5000,000 freshly isolated PMNL cells were resuspended in PGC buffer. After preincubation with the test compounds for 15 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM31124(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11c)
Affinity DataIC50:  84nM EC50:  1.20E+3nMpH: 7.4 T: 2°CAssay Description:For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM31123(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11b)
Affinity DataIC50:  97nM EC50:  1.20E+3nMpH: 7.4 T: 2°CAssay Description:For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM24563(Pirinixic acid-based compound, 6h | ethyl 2-({4-ch...)
Affinity DataIC50:  3.70E+4nM EC50:  1.40E+3nMpH: 7.4 T: 2°CAssay Description:For determination of the activity of 5-LO in 100000g supernatants, aliquots of the supernatants were added to reaction mix, and were preincubated wit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM24562(Pirinixic acid-based compound, 6f | ethyl 2-{[4-ch...)
Affinity DataEC50:  1.70E+3nMpH: 7.4 T: 2°CAssay Description:For assays of intact cells, 5000,000 freshly isolated PMNL cells were resuspended in PGC buffer. After preincubation with the test compounds for 15 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM31113(5-hydroxy-1H-indole-3-carboxylate, 10a)
Affinity DataIC50:  2.00E+3nM EC50:  1.70E+3nMpH: 7.4 T: 2°CAssay Description:For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM31131(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11j)
Affinity DataIC50:  250nM EC50:  1.70E+3nMpH: 7.4 T: 2°CAssay Description:For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM31114(5-hydroxy-1H-indole-3-carboxylate, 10b)
Affinity DataIC50:  1.60E+3nM EC50:  1.70E+3nMpH: 7.4 T: 2°CAssay Description:For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM31137(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11p)
Affinity DataIC50:  650nM EC50:  1.80E+3nMAssay Description:For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM24557(Pirinixic acid-based compound, 4b | ethyl 2-({4-ch...)
Affinity DataEC50:  1.80E+3nMpH: 7.4 T: 2°CAssay Description:For assays of intact cells, 5000,000 freshly isolated PMNL cells were resuspended in PGC buffer. After preincubation with the test compounds for 15 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM31117(5-hydroxy-1H-indole-3-carboxylate, 10l)
Affinity DataIC50:  2.10E+3nM EC50:  2.00E+3nMpH: 7.4 T: 2°CAssay Description:For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM31103(5-hydroxy-1H-indole-3-carboxylate, 37)
Affinity DataIC50:  300nM EC50:  2.40E+3nMpH: 7.4 T: 2°CAssay Description:For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM24554(Pirinixic acid-based compound, 2c | ethyl 2-{[4-ch...)
Affinity DataEC50:  2.60E+3nMpH: 7.4 T: 2°CAssay Description:For assays of intact cells, 5000,000 freshly isolated PMNL cells were resuspended in PGC buffer. After preincubation with the test compounds for 15 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM31135(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11n)
Affinity DataIC50:  49nM EC50:  2.80E+3nMAssay Description:For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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