Compile Data Set for Download or QSAR
maximum 50k data
Found 74 of ec50 data for polymerid = 469,858,50000958
TargetInsulin receptor(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50506238(CHEMBL4457859)
Affinity DataEC50:  4nMAssay Description:Agonist activity at human IR-beta signalling expressed in mouse 3T3 cells assessed as AKT phosphorylation at Ser473 residue after 30 mins by HTRF ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin receptor(Mus musculus)
University Of Melbourne

Curated by ChEMBL
LigandPNGBDBM50459972(CHEMBL4226003)
Affinity DataEC50:  4nMAssay Description:Agonist activity at B6D2F1 mouse insulin receptor assessed as increase in glucose incorporation into lipid phase after 2 hrs in presence of D-[3-3H]g...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50548047(CHEMBL4753825)
Affinity DataEC50:  12nMAssay Description:Activation of human IR-B expressed in mouse NIH3T3 cells assessed as increase in Akt phosphorylation at Ser473 residue incubated for 30 mins by HTRF ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50548048(CHEMBL4764550)
Affinity DataEC50:  12nMAssay Description:Activation of human IR-B expressed in mouse NIH3T3 cells assessed as increase in Akt phosphorylation at Ser473 residue incubated for 30 mins by HTRF ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50548050(CHEMBL4762540)
Affinity DataEC50:  12nMAssay Description:Activation of human IR-B expressed in mouse NIH3T3 cells assessed as increase in Akt phosphorylation at Ser473 residue incubated for 30 mins by HTRF ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50548049(CHEMBL4751178)
Affinity DataEC50:  12nMAssay Description:Activation of human IR-B expressed in mouse NIH3T3 cells assessed as increase in Akt phosphorylation at Ser473 residue incubated for 30 mins by HTRF ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50548051(CHEMBL4748140)
Affinity DataEC50:  12nMAssay Description:Activation of human IR-B expressed in mouse NIH3T3 cells assessed as increase in Akt phosphorylation at Ser473 residue incubated for 30 mins by HTRF ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM313069(1-(6-chloroquinazolin-4-yl)-N3-(4-(2-(pyrrolidin-1...)
Affinity DataEC50:  14nMAssay Description:Inhibition of insulin stimulated INSR phosphorylation in human HeLa cells preincubated for 1 hr followed by insulin addition measured after 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM313084(1-(6-fluoroquinazolin-4-yl)-N3-(4-(2-(pyrrolidin-1...)
Affinity DataEC50:  126nMAssay Description:Inhibition of insulin stimulated INSR phosphorylation in human HeLa cells preincubated for 1 hr followed by insulin addition measured after 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM313027(N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetra...)
Affinity DataEC50:  241nMAssay Description:Inhibition of insulin stimulated INSR phosphorylation in human HeLa cells preincubated for 1 hr followed by insulin addition measured after 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50269393(CHEMBL4078564)
Affinity DataEC50:  300nMAssay Description:Inhibition of insulin stimulated INSR phosphorylation in human HeLa cells preincubated for 1 hr followed by insulin addition measured after 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50092143(2,5-Dihydroxy-3-(1H-indol-3-yl)-6-phenyl-[1,4]benz...)
Affinity DataEC50:  300nMAssay Description:Activation of human insulin receptor tyrosine kinase (IRTK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50092150(2,5-Dihydroxy-3-(1-methyl-1H-indol-3-yl)-6-phenyl-...)
Affinity DataEC50:  300nMAssay Description:Activation of human insulin receptor tyrosine kinase (IRTK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM313086(1-(2-methylquinazolin-4-yl)-N3-(4-(2-(pyrrolidin-1...)
Affinity DataEC50:  320nMAssay Description:Inhibition of insulin stimulated INSR phosphorylation in human HeLa cells preincubated for 1 hr followed by insulin addition measured after 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM313081(1-(2-chloro-7-methylthieno[3,2-d]pyrimidin-4-yl)-N...)
Affinity DataEC50:  582nMAssay Description:Inhibition of insulin stimulated INSR phosphorylation in human HeLa cells preincubated for 1 hr followed by insulin addition measured after 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50092148(2-Benzo[b]thiophen-3-yl-3,6-dihydroxy-5-phenyl-[1,...)
Affinity DataEC50:  1.00E+3nMAssay Description:Activation of human insulin receptor tyrosine kinase (IRTK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM482158(BDBM50242742 | TAE684)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of InsR by cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50269375(CHEMBL4086420)
Affinity DataEC50:  1.01E+3nMAssay Description:Inhibition of insulin stimulated INSR phosphorylation in human HeLa cells preincubated for 1 hr followed by insulin addition measured after 5 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM313137(1-(6,7-dimethoxyquinazolin-4-yl)-N3-(4-(1-methylpi...)
Affinity DataEC50:  1.32E+3nMAssay Description:Inhibition of insulin stimulated INSR phosphorylation in human HeLa cells preincubated for 1 hr followed by insulin addition measured after 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50092146(2-Benzofuran-3-yl-3,6-dihydroxy-5-phenyl-[1,4]benz...)
Affinity DataEC50:  1.50E+3nMAssay Description:Activation of human insulin receptor tyrosine kinase (IRTK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM313124(1-(6,7-dimethoxyquinazolin-4-yl)-N3-(4-(1-methylpi...)
Affinity DataEC50:  1.80E+3nMAssay Description:Inhibition of insulin stimulated INSR phosphorylation in human HeLa cells preincubated for 1 hr followed by insulin addition measured after 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50242740(CHEMBL459850 | N-(3-(7-Amino-1-methyl-2-oxo-1,2-di...)
Affinity DataEC50: >2.00E+3nMAssay Description:Inhibition of InsR by cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50269384(CHEMBL4095081)
Affinity DataEC50:  2.75E+3nMAssay Description:Inhibition of insulin stimulated INSR phosphorylation in human HeLa cells preincubated for 1 hr followed by insulin addition measured after 5 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM313080(N3-(3-chloro-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-...)
Affinity DataEC50:  4.17E+3nMAssay Description:Inhibition of insulin stimulated INSR phosphorylation in human HeLa cells preincubated for 1 hr followed by insulin addition measured after 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50269389(CHEMBL4069483)
Affinity DataEC50:  4.58E+3nMAssay Description:Inhibition of insulin stimulated INSR phosphorylation in human HeLa cells preincubated for 1 hr followed by insulin addition measured after 5 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM313140(1-(6,7-dimethoxyquinazolin-4-yl)-N3-(4-((S)-3-(dim...)
Affinity DataEC50:  4.76E+3nMAssay Description:Inhibition of insulin stimulated INSR phosphorylation in human HeLa cells preincubated for 1 hr followed by insulin addition measured after 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50092149(2-[2-(1,1-Dimethyl-allyl)-1H-indol-3-yl]-3,6-dihyd...)
Affinity DataEC50:  5.00E+3nMAssay Description:Activation of human insulin receptor tyrosine kinase (IRTK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Mus musculus)
University Of Melbourne

Curated by ChEMBL
LigandPNGBDBM50377967(CHEMBL1627107)
Affinity DataEC50:  5.00E+3nMAssay Description:Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50269390(CHEMBL4080190)
Affinity DataEC50:  5.03E+3nMAssay Description:Inhibition of insulin stimulated INSR phosphorylation in human HeLa cells preincubated for 1 hr followed by insulin addition measured after 5 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50092147(2,5-Dihydroxy-3-naphthalen-1-yl-6-phenyl-[1,4]benz...)
Affinity DataEC50:  6.00E+3nMAssay Description:Activation of human insulin receptor tyrosine kinase (IRTK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Mus musculus)
University Of Melbourne

Curated by ChEMBL
LigandPNGBDBM50253185(2-Chloro-5-{[(7-{[(7-{[(4-chloro-3-sulfophenyl)ami...)
Affinity DataEC50:  6.00E+3nMAssay Description:Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50092144(2,5-Dihydroxy-3-(1H-indol-3-yl)-6-(7-methyl-1H-ind...)
Affinity DataEC50:  7.00E+3nMAssay Description:Activation of human insulin receptor tyrosine kinase (IRTK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Mus musculus)
University Of Melbourne

Curated by ChEMBL
LigandPNGBDBM50253181(2-Hydroxy-5-{[(7-{[(7-sulfo(2-naphthyl))amino]carb...)
Affinity DataEC50:  9.00E+3nMAssay Description:Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50269391(CHEMBL4059790)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of insulin stimulated INSR phosphorylation in human HeLa cells preincubated for 1 hr followed by insulin addition measured after 5 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Mus musculus)
University Of Melbourne

Curated by ChEMBL
LigandPNGBDBM50253179(5-{[(7-{[(7-{[(3-Carboxy-4-chlorophenyl)amino]sulf...)
Affinity DataEC50:  1.60E+4nMAssay Description:Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Mus musculus)
University Of Melbourne

Curated by ChEMBL
LigandPNGBDBM50253178(5-{[(7-{[(7-{[(3-Carboxy-4-chlorophenyl)amino]sulf...)
Affinity DataEC50:  1.80E+4nMAssay Description:Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Mus musculus)
University Of Melbourne

Curated by ChEMBL
LigandPNGBDBM50377968(CHEMBL1627106)
Affinity DataEC50:  2.20E+4nMAssay Description:Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Mus musculus)
University Of Melbourne

Curated by ChEMBL
LigandPNGBDBM50253166(3-{7-[({7-[(3-carboxyphenyl)sulfamoyl]naphthalen-2...)
Affinity DataEC50:  2.40E+4nMAssay Description:Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Mus musculus)
University Of Melbourne

Curated by ChEMBL
LigandPNGBDBM50253159(3-{[(4-Hydroxy-7-{[(5-hydroxy-7-{[(3-sulfophenyl)a...)
Affinity DataEC50:  2.60E+4nMAssay Description:Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50092145(2,5-Dihydroxy-3-naphthalen-2-yl-6-phenyl-[1,4]benz...)
Affinity DataEC50:  3.00E+4nMAssay Description:Activation of human insulin receptor tyrosine kinase (IRTK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Mus musculus)
University Of Melbourne

Curated by ChEMBL
LigandPNGBDBM50253182(5-{7-[({7-[(3-carboxy-4-nitrophenyl)sulfamoyl]naph...)
Affinity DataEC50:  4.00E+4nMAssay Description:Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Mus musculus)
University Of Melbourne

Curated by ChEMBL
LigandPNGBDBM50253177(2-{7-[({7-[(2-carboxyphenyl)sulfamoyl]naphthalen-2...)
Affinity DataEC50:  4.10E+4nMAssay Description:Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Mus musculus)
University Of Melbourne

Curated by ChEMBL
LigandPNGBDBM50253180(5-{[(7-{[(7-{[(3-Carboxy-4-hydroxyphenyl)amino]sul...)
Affinity DataEC50:  4.30E+4nMAssay Description:Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Mus musculus)
University Of Melbourne

Curated by ChEMBL
LigandPNGBDBM50253165(3-{7-[({7-[(3-carboxyphenyl)sulfamoyl]-5-hydroxyna...)
Affinity DataEC50:  4.30E+4nMAssay Description:Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Mus musculus)
University Of Melbourne

Curated by ChEMBL
LigandPNGBDBM50253168(1,3-bis(7-{[3-(1H-1,2,3,4-tetrazol-1-yl)phenyl]sul...)
Affinity DataEC50:  5.40E+4nMAssay Description:Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Mus musculus)
University Of Melbourne

Curated by ChEMBL
LigandPNGBDBM50253189(5-[({7-[3-(7-{[(3-Carboxy-4-chlorophenyl)amino]sul...)
Affinity DataEC50:  5.60E+4nMAssay Description:Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Mus musculus)
University Of Melbourne

Curated by ChEMBL
LigandPNGBDBM50253167(1,3-bis(5-hydroxy-7-{[3-(1H-1,2,3,4-tetrazol-1-yl)...)
Affinity DataEC50:  7.30E+4nMAssay Description:Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Mus musculus)
University Of Melbourne

Curated by ChEMBL
LigandPNGBDBM50377965(CHEMBL436679)
Affinity DataEC50:  9.00E+4nMAssay Description:Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Mus musculus)
University Of Melbourne

Curated by ChEMBL
LigandPNGBDBM50253192(CHEMBL505538 | disodium 3-{N-methyl7-[({7-[methyl(...)
Affinity DataEC50:  9.10E+4nMAssay Description:Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Mus musculus)
University Of Melbourne

Curated by ChEMBL
LigandPNGBDBM50253175(2-{7-[({7-[(2-carboxyphenyl)sulfamoyl]-5-hydroxyna...)
Affinity DataEC50:  9.30E+4nMAssay Description:Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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