Compile Data Set for Download or QSAR
maximum 50k data
Found 424 of ec50 data for polymerid = 5360,50002353,50002354,50002694,50003890,50005810
TargetVitamin D3 receptor(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50205233((20S,22R)-22-methyl-1-alpha-25-dihydroxy-vitamin D...)
Affinity DataEC50:  0.00200nMAssay Description:Induction of transactivation of human VDR responsive gene in COS7 cells by rat osteopontin luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Mus musculus)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50005618(CHEMBL2021484)
Affinity DataEC50:  0.00210nMAssay Description:Increase in mouse VDR-mediated transcriptional activity in african green monkey COS7 cells after 24 hrs by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50205234((20S,22R)-22-methyl-1-alpha-25-dihydroxy-vitamin D...)
Affinity DataEC50:  0.00300nMAssay Description:Induction of transactivation of human VDR responsive gene in COS7 cells by rat osteopontin luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50437338(CHEMBL2407821)
Affinity DataEC50:  0.0100nMAssay Description:Transactivation of VDR-mediated osteocalcin promoter in human HOS/SF cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Affinity DataEC50:  0.0100nMAssay Description:Activity at human VDR expressed in human HOS cells transfected with pGL3-hOc, pCDNA-hVDR and phRL-TK assessed as assessed as transcriptional activati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetVitamin D3 receptor(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Affinity DataEC50:  0.0106nMAssay Description:Effect on VDR transcriptional activity in human osteosarcoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetVitamin D3 receptor(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Affinity DataEC50:  0.0110nMAssay Description:Agonist activity at human VDR expressed in HOS cells co-expressing human RXR by Dual-Glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetVitamin D3 receptor(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50565949(CHEMBL4794075)
Affinity DataEC50:  0.0140nMAssay Description:Agonist activity at human VDR expressed in HEK293 cells expressing mouse osteopontin VDRE assessed as induction of receptor transactivation incubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Mus musculus)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50244268((20S)-1-alpha-2-alpha-25-Trihydroxy-2beta-methyl-1...)
Affinity DataEC50:  0.0170nMAssay Description:Increase in mouse VDR-mediated transcriptional activity in african green monkey COS7 cells after 24 hrs by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Bos taurus)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50205233((20S,22R)-22-methyl-1-alpha-25-dihydroxy-vitamin D...)
Affinity DataEC50:  0.0180nMAssay Description:Displacement of [3H]1,25-(OH)2D3 from vitamin D receptor in bovine thymusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50292706((1R,3R,7E,17beta)-17-{(1R,2E,4R)-4-hydroxy-1-methy...)
Affinity DataEC50:  0.0200nMAssay Description:Agonist activity at VDR assessed as receptor transactivation by transient transcription assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50304585((20S)-1alpha,25-Dihydroxy-2-methylene-18,19-dinorv...)
Affinity DataEC50:  0.0200nMAssay Description:Activity at VDR in rat osteosarcoma cells assessed as induction of 24-hydroxylase reporter gene transcription by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Mus musculus)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50244165((1R,2S,3R,5Z,7E)-17-{(1R)-1-[(2-ethyl-2-hydroxybut...)
Affinity DataEC50:  0.0240nMAssay Description:Increase in mouse VDR-mediated transcriptional activity in african green monkey COS7 cells after 24 hrs by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Affinity DataEC50:  0.0260nMAssay Description:Transactivation of VDR-mediated osteocalcin promoter in human HOS/SF cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetVitamin D3 receptor(Mus musculus)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50244240((20S)-(2E)-1-alpha-25-Dihydroxy-2-[2-(hydroxy)-eth...)
Affinity DataEC50:  0.0260nMAssay Description:Increase in mouse VDR-mediated transcriptional activity in african green monkey COS7 cells after 24 hrs by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Mus musculus)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50244164((20S)-1-alpha-25-Dihydroxy-2-alpha-(2-hydroxyethox...)
Affinity DataEC50:  0.0270nMAssay Description:Increase in mouse VDR-mediated transcriptional activity in african green monkey COS7 cells after 24 hrs by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Mus musculus)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50244241((20R)-(2E)-1-alpha-25-Dihydroxy-2-[2-(hydroxy)-eth...)
Affinity DataEC50:  0.0290nMAssay Description:Increase in mouse VDR-mediated transcriptional activity in african green monkey COS7 cells after 24 hrs by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50281390(CHEMBL4159525)
Affinity DataEC50:  0.0300nMAssay Description:Transactivation of VDR (unknown origin) expressed in HEK293 cells harboring TK-Spp X 3-LUC reporter plasmid after 24 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Mus musculus)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50412386(CHEMBL2021486)
Affinity DataEC50:  0.0300nMAssay Description:Increase in mouse VDR-mediated transcriptional activity in african green monkey COS7 cells after 24 hrs by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Bos taurus)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50205234((20S,22R)-22-methyl-1-alpha-25-dihydroxy-vitamin D...)
Affinity DataEC50:  0.0310nMAssay Description:Displacement of [3H]1,25-(OH)2D3 from vitamin D receptor in bovine thymusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50329706((2S)-3-{4-[1-ethyl-1-(4-{[(2R)-2-hydroxy-3,3-dimet...)
Affinity DataEC50:  0.0396nMAssay Description:Effect on VDR transcriptional activity in human osteosarcoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50329706((2S)-3-{4-[1-ethyl-1-(4-{[(2R)-2-hydroxy-3,3-dimet...)
Affinity DataEC50:  0.0400nMAssay Description:Agonist activity at human VDR expressed in HOS cells co-expressing human RXR by Dual-Glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50329706((2S)-3-{4-[1-ethyl-1-(4-{[(2R)-2-hydroxy-3,3-dimet...)
Affinity DataEC50:  0.0400nMAssay Description:Activity at human VDR expressed in human HOS cells transfected with pGL3-hOc, pCDNA-hVDR and phRL-TK assessed as assessed as transcriptional activati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50437335(CHEMBL2407824)
Affinity DataEC50:  0.0440nMAssay Description:Transactivation of VDR-mediated osteocalcin promoter in human HOS/SF cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Affinity DataEC50:  0.0500nMAssay Description:Displacement of 1-alpha,25-dihydroxyvitamin from rat recombinant VDRMore data for this Ligand-Target Pair
TargetVitamin D3 receptor(Bos taurus)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Affinity DataEC50:  0.0500nMAssay Description:Displacement of [3H]1,25-(OH)2D3 from bovine thymus vitamin D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Mus musculus)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50412386(CHEMBL2021486)
Affinity DataEC50:  0.0580nMAssay Description:Increase in mouse VDR-mediated transcriptional activity in african green monkey COS7 cells after 24 hrs by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50304583(1alpha,25-Dihydroxy-2-methylene-18,19,21-trinorvit...)
Affinity DataEC50:  0.0600nMAssay Description:Activity at VDR in rat osteosarcoma cells assessed as induction of 24-hydroxylase reporter gene transcription by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50354990(CHEMBL1834893)
Affinity DataEC50:  0.0600nMAssay Description:Activity at human VDR expressed in human HOS cells transfected with pGL3-hOc, pCDNA-hVDR and phRL-TK assessed as assessed as transcriptional activati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50198707((2E)-(20S)-1alpha,25-dihydroxy-2-[2''-(fluoroethyl...)
Affinity DataEC50:  0.0700nMAssay Description:Inhibition of human VDR induced-transcriptional transactivation of luciferase reporter gene in COS7 cells after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50015318(CHEMBL3263871)
Affinity DataEC50:  0.0700nMAssay Description:Transactivation of human VDR expressed in HEK293 cells cotransfected with mouse VDRE, Tk-Sppx3-LUC reporter plasmid measured after 24 hrs by lucifera...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Affinity DataEC50:  0.0700nMAssay Description:Transactivation of VP16-tagged VDR (unknown origin) expressed in HEK293 cells harboring pCMX-GAL4-RXRalpha and MH100(UAS) X 4tk-LUC reporter plasmid ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetVitamin D3 receptor(Bos taurus)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Affinity DataEC50:  0.0710nMAssay Description:Displacement of [3H]1,25-(OH)2D3 from vitamin D receptor in bovine thymusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Mus musculus)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50244240((20S)-(2E)-1-alpha-25-Dihydroxy-2-[2-(hydroxy)-eth...)
Affinity DataEC50:  0.0850nMAssay Description:Increase in mouse VDR-mediated transcriptional activity in african green monkey COS7 cells after 24 hrs by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Mus musculus)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50412385(CHEMBL2021488)
Affinity DataEC50:  0.0900nMAssay Description:Increase in mouse VDR-mediated transcriptional activity in african green monkey COS7 cells after 24 hrs by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Mus musculus)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50412385(CHEMBL2021488)
Affinity DataEC50:  0.0900nMAssay Description:Increase in mouse VDR-mediated transcriptional activity in african green monkey COS7 cells after 24 hrs by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Affinity DataEC50:  0.100nMAssay Description:Agonist activity at human VDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetVitamin D3 receptor(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Affinity DataEC50:  0.100nMAssay Description:Displacement of [3H]1,25-(OH)2D3 from rat recombinant His-tagged VDR ligand-binding domain expressed in Escherichia coli BL21More data for this Ligand-Target Pair
TargetVitamin D3 receptor(Mus musculus)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50244165((1R,2S,3R,5Z,7E)-17-{(1R)-1-[(2-ethyl-2-hydroxybut...)
Affinity DataEC50:  0.115nMAssay Description:Increase in mouse VDR-mediated transcriptional activity in african green monkey COS7 cells after 24 hrs by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Mus musculus)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50244269((20R)-1-alpha-2-alpha-25-Trihydroxy-2-beta-methyl-...)
Affinity DataEC50:  0.120nMAssay Description:Increase in mouse VDR-mediated transcriptional activity in african green monkey COS7 cells after 24 hrs by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Affinity DataEC50:  0.120nMAssay Description:Agonist activity at VDR in human HEK293 cells assessed as transcriptional activity after 16 to 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetVitamin D3 receptor(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50281390(CHEMBL4159525)
Affinity DataEC50:  0.140nMAssay Description:Transactivation of VP16-tagged VDR (unknown origin) expressed in HEK293 cells harboring pCMX-GAL4-RXRalpha and MH100(UAS) X 4tk-LUC reporter plasmid ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50437336(CHEMBL2407823)
Affinity DataEC50:  0.150nMAssay Description:Transactivation of VDR-mediated osteocalcin promoter in human HOS/SF cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50565950(CHEMBL4776651)
Affinity DataEC50:  0.150nMAssay Description:Agonist activity at human VDR expressed in HEK293 cells expressing mouse osteopontin VDRE assessed as induction of receptor transactivation incubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50143770((1R,3S)-5-[2-[(3aS,7aR)-1-((R)-5-Hydroxy-1,5-dimet...)
Affinity DataEC50:  0.180nMAssay Description:Effective concentration required for inhibition of Vitamin D3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Affinity DataEC50:  0.200nMAssay Description:Activity at VDR in rat osteosarcoma cells assessed as 24-hydroxylase transcription by reporter gene assayMore data for this Ligand-Target Pair
TargetVitamin D3 receptor(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50304584(1alpha,25-Dihydroxy-2-methylene-19,21-dinorvitamin...)
Affinity DataEC50:  0.200nMAssay Description:Activity at VDR in rat osteosarcoma cells assessed as induction of 24-hydroxylase reporter gene transcription by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Mus musculus)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50244241((20R)-(2E)-1-alpha-25-Dihydroxy-2-[2-(hydroxy)-eth...)
Affinity DataEC50:  0.200nMAssay Description:Increase in mouse VDR-mediated transcriptional activity in african green monkey COS7 cells after 24 hrs by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Affinity DataEC50:  0.200nMAssay Description:Activity at VDR in rat ROS 17/2.8 cells assessed as transcriptional activation of 24-hydroxylase gene promoter after 16 hrs by luciferase reporter ge...More data for this Ligand-Target Pair
TargetVitamin D3 receptor(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50205235((20S,22R)-22-methyl-1-alpha-25-dihydroxy-vitamin D...)
Affinity DataEC50:  0.200nMAssay Description:Induction of transactivation of human VDR responsive gene in COS7 cells by rat osteopontin luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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