TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma brucei brucei)
Vyera Pharmaceuticals
US Patent
Vyera Pharmaceuticals
US Patent
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma brucei brucei)
Vyera Pharmaceuticals
US Patent
Vyera Pharmaceuticals
US Patent
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma brucei brucei)
Vyera Pharmaceuticals
US Patent
Vyera Pharmaceuticals
US Patent
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma brucei brucei)
Vyera Pharmaceuticals
US Patent
Vyera Pharmaceuticals
US Patent
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma brucei brucei)
Vyera Pharmaceuticals
US Patent
Vyera Pharmaceuticals
US Patent
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma brucei brucei)
Vyera Pharmaceuticals
US Patent
Vyera Pharmaceuticals
US Patent
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma brucei brucei)
Vyera Pharmaceuticals
US Patent
Vyera Pharmaceuticals
US Patent
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma brucei brucei)
Vyera Pharmaceuticals
US Patent
Vyera Pharmaceuticals
US Patent
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma brucei brucei)
Vyera Pharmaceuticals
US Patent
Vyera Pharmaceuticals
US Patent
Affinity DataIC50: 8.90nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
Affinity DataIC50: 9.60nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of thrombin in rat plasmaMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of bovine thrombin-catalyzed hydrolysis of fibrinogenMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:In vitro concentration of compound required to inhibit 50% of 6 nM thrombinMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of bovine thrombin-catalyzed hydrolysis of fibrinogenMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:In vitro concentration of compound required to inhibit 50% of 6 nM thrombinMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma brucei brucei)
Vyera Pharmaceuticals
US Patent
Vyera Pharmaceuticals
US Patent
Affinity DataIC50: 45nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of bovine thrombin-catalyzed hydrolysis of fibrinogenMore data for this Ligand-Target Pair
Affinity DataIC50: 59nMAssay Description:Inhibition of bovine thrombin-catalyzed hydrolysis of fibrinogenMore data for this Ligand-Target Pair
Affinity DataIC50: 64nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of bovine thrombin-catalyzed hydrolysis of S-2238More data for this Ligand-Target Pair
Affinity DataIC50: 88nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of bovine thrombin-catalyzed hydrolysis of S-2238More data for this Ligand-Target Pair
Affinity DataIC50: 148nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford Burnham Medical Research Institute (SBMRI, La Jolla, CA...More data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Bovine thrombin concentration at which clotting time was prolonged 2x over the control.More data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Inhibition of bovine thrombin-catalyzed hydrolysis of fibrinogenMore data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Inhibition of bovine thrombin-catalyzed hydrolysis of S-2238More data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of bovine thrombin-catalyzed hydrolysis of S-2238More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Bovine thrombin concentration at which clotting time was prolonged 2x over the control.More data for this Ligand-Target Pair
Affinity DataIC50: 280nMAssay Description:Inhibition of bovine thrombin-catalyzed hydrolysis of S-2238More data for this Ligand-Target Pair
Affinity DataIC50: 290nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Bovine thrombin concentration at which clotting time was prolonged 2x over the control.More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Bovine thrombin concentration at which clotting time was prolonged 2x over the control.More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma brucei brucei)
Vyera Pharmaceuticals
US Patent
Vyera Pharmaceuticals
US Patent
Affinity DataIC50: 468nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford Burnham Medical Research Institute (SBMRI, La Jolla, CA...More data for this Ligand-Target Pair
Affinity DataIC50: 529nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford Burnham Medical Research Institute (SBMRI, La Jolla, CA...More data for this Ligand-Target Pair
Affinity DataIC50: 564nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford Burnham Medical Research Institute (SBMRI, La Jolla, CA...More data for this Ligand-Target Pair
Affinity DataIC50: 670nMAssay Description:Bovine thrombin concentration at which clotting time was prolonged 2x over the control.More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Bovine thrombin concentration at which clotting time was prolonged 2x over the control.More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of thrombin with benzoyl-Phe-Val-arginine- p-nitroanilide as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 1.37E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford Burnham Medical Research Institute (SBMRI, La Jolla, CA...More data for this Ligand-Target Pair