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Found 470 of ic50 data for polymerid = 4401,5533
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98812(US8487093, 204)
Affinity DataIC50:  0.800nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98802(US8487093, 192)
Affinity DataIC50:  0.800nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98861(US8487093, 7)
Affinity DataIC50:  1.10nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98792(US8487093, 180)
Affinity DataIC50:  1.20nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98862(US8487093, 8)
Affinity DataIC50:  1.60nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Escherichia coli)
Entasis Therapeutics

US Patent
LigandPNGBDBM466971(2-fluoro-2-(((2S,5R)-3-methyl-7-oxo-2-((pyrazin-2-...)
Affinity DataIC50:  1.80nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98819(US8487093, 212)
Affinity DataIC50:  1.80nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetBeta-lactamase(Escherichia coli)
Entasis Therapeutics

US Patent
LigandPNGBDBM50149466(CHEMBL124416 | Sodium; (R)-6-[1-(5,6-dihydro-4H-py...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibitory activity against Class C (Amp-C) beta-LactamasesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Escherichia coli)
Entasis Therapeutics

US Patent
LigandPNGBDBM50149467((5R,6Z)-6-(6,7-dihydro-5H-cyclopenta-[d]imidazo[2,...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibitory activity against Class C (Amp-C) beta-LactamasesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98806(US8487093, 196)
Affinity DataIC50:  2nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Escherichia coli)
Entasis Therapeutics

US Patent
LigandPNGBDBM466985((2S)-2-fluoro-2-[[(2S,5R)-3-methyl-7-oxo-2-(pyrazi...)
Affinity DataIC50:  2nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98799(US8487093, 188)
Affinity DataIC50:  2nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Escherichia coli)
Entasis Therapeutics

US Patent
LigandPNGBDBM466999((2S)-2-fluoro-2-[[(2S,5R)-3-methyl-7-oxo-2-[(sulfa...)
Affinity DataIC50:  2.10nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98790(US8487093, 176)
Affinity DataIC50:  3nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98800(US8487093, 190)
Affinity DataIC50:  3nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98798(US8487093, 186)
Affinity DataIC50:  3nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Escherichia coli)
Entasis Therapeutics

US Patent
LigandPNGBDBM466998((2S)-2-fluoro-2-[[(2S,5R)-2-(acetamidomethylcarbam...)
Affinity DataIC50:  3.10nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98810(US8487093, 200)
Affinity DataIC50:  4nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Escherichia coli)
Entasis Therapeutics

US Patent
LigandPNGBDBM466979((2S)-2-fluoro-2-[[(2S,5R)-3-methyl-7-oxo-2-(2-sulf...)
Affinity DataIC50:  4.10nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-lactamase(Escherichia coli)
Entasis Therapeutics

US Patent
LigandPNGBDBM466987((2S)-2-[[(2S,5R)-2-[(3-amino-3-oxo-propyl)carbamoy...)
Affinity DataIC50:  4.40nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98808(US8487093, 198)
Affinity DataIC50:  5nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Escherichia coli)
Entasis Therapeutics

US Patent
LigandPNGBDBM50149468(CHEMBL263746 | Sodium; (R)-6-[1-(5,6-dihydro-8H-im...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibitory activity against Class C (Amp-C) beta-LactamasesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Escherichia coli)
Entasis Therapeutics

US Patent
LigandPNGBDBM50149469(CHEMBL331090 | Sodium; (R)-7-oxo-6-[1-(5,6,7,8-tet...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibitory activity against Class C (Amp-C) beta-LactamasesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98811(US8487093, 202)
Affinity DataIC50:  6nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98854(US8487093, 17)
Affinity DataIC50:  6nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98860(US8487093, 6)
Affinity DataIC50:  6nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98788(US8487093, 172)
Affinity DataIC50:  7nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98789(US8487093, 174)
Affinity DataIC50:  7nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Escherichia coli)
Entasis Therapeutics

US Patent
LigandPNGBDBM466983((2S)-2-fluoro-2-[[(2S,5R)-2-[2-(methanesulfonamido...)
Affinity DataIC50:  7.30nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-lactamase(Escherichia coli)
Entasis Therapeutics

US Patent
LigandPNGBDBM50114518(CHEMBL297805 | Sodium; (R)-3-methanesulfonyl-5,5,8...)
Affinity DataIC50:  7.60nMAssay Description:Inhibitory activity against class A TEM-1 beta-lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98796(US8487093, 184)
Affinity DataIC50:  8nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Escherichia coli)
Entasis Therapeutics

US Patent
LigandPNGBDBM50114514(CHEMBL44932 | Sodium; (R)-3-[(E)-2-(2-guanidino-et...)
Affinity DataIC50:  8.30nMAssay Description:Inhibitory activity against class A TEM-1 beta-lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Escherichia coli)
Entasis Therapeutics

US Patent
LigandPNGBDBM466970(2-(((2S,5R)-2-(2-acetylhydrazinecarbonyl)-3-methyl...)
Affinity DataIC50:  8.30nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-lactamase(Escherichia coli)
Entasis Therapeutics

US Patent
LigandPNGBDBM466984((2S)-2-fluoro-2-[[(2S,5R)-3-methyl-2-(oxazol-2-ylm...)
Affinity DataIC50:  9.30nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-lactamase(Escherichia coli)
Entasis Therapeutics

US Patent
LigandPNGBDBM50114516(CHEMBL295322 | Sodium; (R)-3-benzenesulfonyl-5,5,8...)
Affinity DataIC50:  9.40nMAssay Description:Inhibitory activity against class A TEM-1 beta-lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98742(US8487093, 90)
Affinity DataIC50:  9.5nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98820(US8487093, 214)
Affinity DataIC50:  10nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetBeta-lactamase(Escherichia coli)
Entasis Therapeutics

US Patent
LigandPNGBDBM466989((2S)-2-fluoro-2-[[(2S,5R)-3-methyl-7-oxo-2-[2-(5-o...)
Affinity DataIC50:  10nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-lactamase(Escherichia coli)
Entasis Therapeutics

US Patent
LigandPNGBDBM466965((2R)-{[(2S,5R)-2-carbamoyl-3-methyl-7-oxo-1,6-diaz...)
Affinity DataIC50:  11nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98787(US8487093, 170)
Affinity DataIC50:  11nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98759(US8487093, 124)
Affinity DataIC50:  11nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Escherichia coli)
Entasis Therapeutics

US Patent
LigandPNGBDBM466967(US10800778, Example 8 | {[(2S,5R)-2-carbamoyl-3-me...)
Affinity DataIC50:  12nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-lactamase(Escherichia coli)
Entasis Therapeutics

US Patent
LigandPNGBDBM50114521(CHEMBL42528 | Sodium; (R)-5,5,8-trioxo-3-phenylsul...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity against class A TEM-1 beta-lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98750(US8487093, 106)
Affinity DataIC50:  13nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Escherichia coli)
Entasis Therapeutics

US Patent
LigandPNGBDBM466991((2S)-2-fluoro-2-[[(2S,5R)-3-methyl-7-oxo-2-[2-(sul...)
Affinity DataIC50:  14nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98783(US8487093, 164)
Affinity DataIC50:  14nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98853(US8487093, 16)
Affinity DataIC50:  14nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Escherichia coli)
Entasis Therapeutics

US Patent
LigandPNGBDBM466996((2S)-2-fluoro-2-[[(2S,5R)-2-(cyanomethylcarbamoyl)...)
Affinity DataIC50:  14nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-lactamase(Escherichia coli)
Entasis Therapeutics

US Patent
LigandPNGBDBM50021959(CHEMBL777 | MM 14151 | US9120808, Clavulanic acid ...)
Affinity DataIC50:  15nMAssay Description:Inhibitory activity against Escherichia coli TEM-3 Beta-lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98758(US8487093, 122)
Affinity DataIC50:  15nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
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