Compile Data Set for Download or QSAR
maximum 50k data
Found 93 of ic50 data for polymerid = 671
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM393292(US9963443, Reference Example 21)
Affinity DataIC50:  4.90nMAssay Description:For the measurement of CH24H inhibitory activity, using the human CH24H lysate prepared in Experimental Example 2, the amount of 24-HC produced from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM393278(US9963443, Reference Example 1)
Affinity DataIC50:  5.40nMAssay Description:For the measurement of CH24H inhibitory activity, using the human CH24H lysate prepared in Experimental Example 2, the amount of 24-HC produced from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM393291(US9963443, Reference Example 20)
Affinity DataIC50:  6.90nMAssay Description:For the measurement of CH24H inhibitory activity, using the human CH24H lysate prepared in Experimental Example 2, the amount of 24-HC produced from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM393282(US9963443, Reference Example 4)
Affinity DataIC50:  7.10nMAssay Description:For the measurement of CH24H inhibitory activity, using the human CH24H lysate prepared in Experimental Example 2, the amount of 24-HC produced from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50583509(CHEMBL5093928)
Affinity DataIC50:  7.30nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50583519(OV-935 | OV935 | SOTICLESTAT | Soticlestat | TAK-9...)
Affinity DataIC50:  7.40nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM393280(US9963443, Reference Example 3)
Affinity DataIC50:  7.40nMAssay Description:For the measurement of CH24H inhibitory activity, using the human CH24H lysate prepared in Experimental Example 2, the amount of 24-HC produced from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50583501(CHEMBL4594072)
Affinity DataIC50:  8.10nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50583512(CHEMBL4532699)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM393279(US9963443, Reference Example 2)
Affinity DataIC50:  8.80nMAssay Description:For the measurement of CH24H inhibitory activity, using the human CH24H lysate prepared in Experimental Example 2, the amount of 24-HC produced from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50583515(CHEMBL4527933)
Affinity DataIC50:  9.5nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM393297(US9963443, Reference Example 26)
Affinity DataIC50:  10nMAssay Description:For the measurement of CH24H inhibitory activity, using the human CH24H lysate prepared in Experimental Example 2, the amount of 24-HC produced from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50583518(CHEMBL5083867)
Affinity DataIC50:  12nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50583517(CHEMBL4538165)
Affinity DataIC50:  12nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50583508(CHEMBL5076011)
Affinity DataIC50:  14nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM393285(US9963443, Reference Example 11)
Affinity DataIC50:  16nMAssay Description:For the measurement of CH24H inhibitory activity, using the human CH24H lysate prepared in Experimental Example 2, the amount of 24-HC produced from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50583507(CHEMBL5082831)
Affinity DataIC50:  16nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM393296(US9963443, Reference Example 23)
Affinity DataIC50:  17nMAssay Description:For the measurement of CH24H inhibitory activity, using the human CH24H lysate prepared in Experimental Example 2, the amount of 24-HC produced from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM393288(US9963443, Reference Example 14)
Affinity DataIC50:  17nMAssay Description:For the measurement of CH24H inhibitory activity, using the human CH24H lysate prepared in Experimental Example 2, the amount of 24-HC produced from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM393283(US9963443, Reference Example 5)
Affinity DataIC50:  19nMAssay Description:For the measurement of CH24H inhibitory activity, using the human CH24H lysate prepared in Experimental Example 2, the amount of 24-HC produced from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM393286(US9963443, Reference Example 13)
Affinity DataIC50:  20nMAssay Description:For the measurement of CH24H inhibitory activity, using the human CH24H lysate prepared in Experimental Example 2, the amount of 24-HC produced from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM393284(US9963443, Reference Example 10)
Affinity DataIC50:  20nMAssay Description:For the measurement of CH24H inhibitory activity, using the human CH24H lysate prepared in Experimental Example 2, the amount of 24-HC produced from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50583514(CHEMBL4580834)
Affinity DataIC50:  24nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50583506(CHEMBL5087082)
Affinity DataIC50:  28nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50583503(CHEMBL4561003)
Affinity DataIC50:  44nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50583511(CHEMBL5083692)
Affinity DataIC50:  48nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50583499(CHEMBL4555625)
Affinity DataIC50:  52nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50583505(CHEMBL5094350)
Affinity DataIC50:  58nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50583516(CHEMBL5082660)
Affinity DataIC50:  65nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50583510(CHEMBL5080231)
Affinity DataIC50:  68nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50583504(CHEMBL5085981)
Affinity DataIC50:  72nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50583500(CHEMBL5074135)
Affinity DataIC50:  74nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM621735(BDBM621792 | US11802122, Example 1A | US2023031252...)
Affinity DataIC50: <100nMAssay Description:Briefly, in a 384-well plate format, 10 uL per well of an enzyme-substrate mixture of CYP46A1 (5 uM final concentration) and Testosterone (10 mM fina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM621735(BDBM621792 | US11802122, Example 1A | US2023031252...)
Affinity DataIC50: <100nMAssay Description:Briefly, in a 384-well plate format, 10 uL per well of an enzyme-substrate mixture of CYP46A1 (5 uM final concentration) and Testosterone (10 mM fina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM621737(BDBM621794 | US11802122, Example 2A | US2023031252...)
Affinity DataIC50: <100nMAssay Description:Briefly, in a 384-well plate format, 10 uL per well of an enzyme-substrate mixture of CYP46A1 (5 uM final concentration) and Testosterone (10 mM fina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM621739(BDBM621797 | US11802122, Example 3A | US2023031252...)
Affinity DataIC50: <100nMAssay Description:Briefly, in a 384-well plate format, 10 uL per well of an enzyme-substrate mixture of CYP46A1 (5 uM final concentration) and Testosterone (10 mM fina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM621741(BDBM621799 | US11802122, Example 4A | US2023031252...)
Affinity DataIC50: <100nMAssay Description:Briefly, in a 384-well plate format, 10 uL per well of an enzyme-substrate mixture of CYP46A1 (5 uM final concentration) and Testosterone (10 mM fina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM621741(BDBM621799 | US11802122, Example 4A | US2023031252...)
Affinity DataIC50: <100nMAssay Description:Briefly, in a 384-well plate format, 10 uL per well of an enzyme-substrate mixture of CYP46A1 (5 uM final concentration) and Testosterone (10 mM fina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM621743(BDBM621800 | US11802122, Example 5A | US2023031252...)
Affinity DataIC50: <100nMAssay Description:Briefly, in a 384-well plate format, 10 uL per well of an enzyme-substrate mixture of CYP46A1 (5 uM final concentration) and Testosterone (10 mM fina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM621746(BDBM621803 | US11802122, Example 7A | US2023031252...)
Affinity DataIC50: <100nMAssay Description:Briefly, in a 384-well plate format, 10 uL per well of an enzyme-substrate mixture of CYP46A1 (5 uM final concentration) and Testosterone (10 mM fina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM621749(US20230312522, Compound 13)
Affinity DataIC50: <100nMAssay Description:Briefly, in a 384-well plate format, 10 uL per well of an enzyme-substrate mixture of CYP46A1 (5 uM final concentration) and Testosterone (10 mM fina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM621750(US20230312522, Compound 14)
Affinity DataIC50: <100nMAssay Description:Briefly, in a 384-well plate format, 10 uL per well of an enzyme-substrate mixture of CYP46A1 (5 uM final concentration) and Testosterone (10 mM fina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM621751(US20230312522, Compound 18)
Affinity DataIC50: <100nMAssay Description:Briefly, in a 384-well plate format, 10 uL per well of an enzyme-substrate mixture of CYP46A1 (5 uM final concentration) and Testosterone (10 mM fina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM621752(US20230312522, Compound 19)
Affinity DataIC50: <100nMAssay Description:Briefly, in a 384-well plate format, 10 uL per well of an enzyme-substrate mixture of CYP46A1 (5 uM final concentration) and Testosterone (10 mM fina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM621753(US20230312522, Compound 20)
Affinity DataIC50: <100nMAssay Description:Briefly, in a 384-well plate format, 10 uL per well of an enzyme-substrate mixture of CYP46A1 (5 uM final concentration) and Testosterone (10 mM fina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM621755(US20230312522, Compound 22)
Affinity DataIC50: <100nMAssay Description:Briefly, in a 384-well plate format, 10 uL per well of an enzyme-substrate mixture of CYP46A1 (5 uM final concentration) and Testosterone (10 mM fina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM621756(US20230312522, Compound 23)
Affinity DataIC50: <100nMAssay Description:Briefly, in a 384-well plate format, 10 uL per well of an enzyme-substrate mixture of CYP46A1 (5 uM final concentration) and Testosterone (10 mM fina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM621757(US20230312522, Compound 24)
Affinity DataIC50: <100nMAssay Description:Briefly, in a 384-well plate format, 10 uL per well of an enzyme-substrate mixture of CYP46A1 (5 uM final concentration) and Testosterone (10 mM fina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM621759(US20230312522, Compound 26)
Affinity DataIC50: <100nMAssay Description:Briefly, in a 384-well plate format, 10 uL per well of an enzyme-substrate mixture of CYP46A1 (5 uM final concentration) and Testosterone (10 mM fina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholesterol 24-hydroxylase(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM621761(US20230312522, Compound 28)
Affinity DataIC50: <100nMAssay Description:Briefly, in a 384-well plate format, 10 uL per well of an enzyme-substrate mixture of CYP46A1 (5 uM final concentration) and Testosterone (10 mM fina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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