Compile Data Set for Download or QSAR
Report error Found 186 of kd data for polymerid = 1747,2218,50004322
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338038BDBM50338038(US8575391, 334 | 3,4-difluoro-2-[(2-fluoro-4-iodop...)
Affinity DataKd:  0.240nMAssay Description:Binding affinity to MEK1 by surface plasmon resonance in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 104963BDBM104963(CHEMBL507361 | US8575391, Q | US11147816, PD032590...)
Affinity DataKd:  0.400nMAssay Description:Binding affinity to MEK1 by surface plasmon resonance in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50308060BDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  3.5nMAssay Description:Binding constant for MEK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50308060BDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  3.5nMAssay Description:Binding affinity to MEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50652792BDBM50652792(CHEMBL3752910)
Affinity DataKd:  3.70nMAssay Description:Binding affinity to human MAP2K1 incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338038BDBM50338038(US8575391, 334 | 3,4-difluoro-2-[(2-fluoro-4-iodop...)
Affinity DataKd:  8.70nMAssay Description:Binding affinity to MEK1 by surface plasmon resonance in absence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50248946BDBM50248946(CHEMBL1908392 | US10981896, Compound 16 | Nintedan...)
Affinity DataKd:  10nMAssay Description:Binding constant for MEK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50355504BDBM50355504(CHEMBL1908393)
Affinity DataKd:  12nMAssay Description:Binding constant for MEK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50161957BDBM50161957(CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...)
Affinity DataKd:  14nMAssay Description:Binding constant for MEK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4552BDBM4552(CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...)
Affinity DataKd:  19nMAssay Description:Binding constant for MEK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  21nMAssay Description:Binding constant for MEK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 31096BDBM31096(CHEMBL290084 | Staurosporine | cid_451705 | US2024...)
Affinity DataKd:  21nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  21nMAssay Description:Binding constant for full-length MEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 104963BDBM104963(CHEMBL507361 | US8575391, Q | US11147816, PD032590...)
Affinity DataKd:  31nMAssay Description:Binding affinity to MEK1 by surface plasmon resonance in absence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 104963BDBM104963(CHEMBL507361 | US8575391, Q | US11147816, PD032590...)
Affinity DataKd:  44nMAssay Description:Binding affinity to MEK1 (unknown origin) incubated for 1 hr by qPCR based KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 36409BDBM36409(CID24905147 | 2-(4-amino-1-isopropyl-1H-pyrazolo[3...)
Affinity DataKd:  51nMAssay Description:Binding constant for MEK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 473172BDBM473172(US10844038, Example 46 B. | (3R,4R)-3-((4-amino-3-...)
Affinity DataKd:  52nMAssay Description:Kd: For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 473171BDBM473171(US10844038, Example 43 B. | (3R,4S)-3-((4-amino-3-...)
Affinity DataKd:  52nMAssay Description:Kd: For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50652793BDBM50652793(CHEMBL5653589)
Affinity DataKd:  57nMAssay Description:Binding affinity to human MAP2K1 incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 31095BDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  77nMAssay Description:Binding constant for full-length MEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 31095BDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  77nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 31095BDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  77nMAssay Description:Binding constant for MEK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50355497BDBM50355497(AZD-6244 | CHEMBL1614701)
Affinity DataKd:  99nMAssay Description:Binding constant for MEK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50132260BDBM50132260(CHEMBL105442 | US8575391, 341 | CI-1040 | 2-(2-chl...)
Affinity DataKd:  120nMAssay Description:Binding constant for MEK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4814BDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  130nMAssay Description:Binding constant for MEK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4814BDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  130nMAssay Description:Binding constant for full-length MEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4814BDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  130nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4814BDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  130nMAssay Description:Binding affinity to MEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50355499BDBM50355499(CHEMBL1908395 | CHEMBL1908842 | US20250129067, Com...)
Affinity DataKd:  200nMAssay Description:Binding constant for MEK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 60665BDBM60665(US9145414, R406 | US9212178, R406 | BDBM50249542 |...)
Affinity DataKd:  320nMAssay Description:Binding constant for MEK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50505541BDBM50505541(CHEMBL4465866)
Affinity DataKd:  328nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-tagged MAP2K1 (unknown origin) expressed in baculovirus infected Sf9 insect cells inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50550043BDBM50550043(CHEMBL4795273)
Affinity DataKd:  330nMAssay Description:Binding affinity to full length biotinylated 6His/Avi-tagged/Tev-fused human MEK1 expressed in Escherichia coli in presence of AMP-PNP by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 31090BDBM31090((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...)
Affinity DataKd:  360nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 31090BDBM31090((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...)
Affinity DataKd:  360nMAssay Description:Binding constant for full-length MEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50556787BDBM50556787(CHEMBL4780600)
Affinity DataKd:  380nMAssay Description:Binding affinity to MEK1 (unknown origin) incubated for 1 hr by qPCR based KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50556785BDBM50556785(CHEMBL4787502)
Affinity DataKd:  400nMAssay Description:Binding affinity to MEK1 (unknown origin) incubated for 1 hr by qPCR based KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50556784BDBM50556784(CHEMBL4741845)
Affinity DataKd:  400nMAssay Description:Binding affinity to MEK1 (unknown origin) incubated for 1 hr by qPCR based KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50505542BDBM50505542(CHEMBL4576489)
Affinity DataKd:  428nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-tagged MAP2K1 (unknown origin) expressed in baculovirus infected Sf9 insect cells inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25118BDBM25118(4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...)
Affinity DataKd:  520nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25118BDBM25118(4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...)
Affinity DataKd:  520nMAssay Description:Binding constant for full-length MEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25118BDBM25118(4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...)
Affinity DataKd:  520nMAssay Description:Binding constant for MEK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50355496BDBM50355496(CHEMBL1908397)
Affinity DataKd:  530nMAssay Description:Binding constant for MEK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 473175BDBM473175(US10844038, Example 46 A. | (3S,4S)-3-((4-amino-3-...)
Affinity DataKd:  550nMAssay Description:Kd: For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 482158BDBM482158(TAE684 | BDBM50242742)
Affinity DataKd:  550nMAssay Description:Binding constant for MEK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25617BDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd:  550nMAssay Description:Binding constant for MEK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50550043BDBM50550043(CHEMBL4795273)
Affinity DataKd:  660nMAssay Description:Binding affinity to full length biotinylated 6His/Avi-tagged/Tev-fused human MEK1 expressed in Escherichia coli in absence of AMP-PNP by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50556786BDBM50556786(CHEMBL4744750)
Affinity DataKd:  660nMAssay Description:Binding affinity to MEK1 (unknown origin) incubated for 1 hr by qPCR based KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50556788BDBM50556788(CHEMBL4753440)
Affinity DataKd:  820nMAssay Description:Binding affinity to MEK1 (unknown origin) incubated for 1 hr by qPCR based KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 6568BDBM6568(PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...)
Affinity DataKd:  830nMAssay Description:Binding constant for MEK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 13216BDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKd:  1.00E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
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