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TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM142745(US8937193, 6a)
Affinity DataKd:  2.80E+3nMAssay Description:The synthesized compounds of Formula I may be screened by one-dimensional 1H nuclear magnetic resonance spectroscopy (1D-1H NMR) binding assays again...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2015
Entry Details
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TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM142750(US8937193, 6b)
Affinity DataKd:  1.50E+3nMAssay Description:The synthesized compounds of Formula I may be screened by one-dimensional 1H nuclear magnetic resonance spectroscopy (1D-1H NMR) binding assays again...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/8/2015
Entry Details
Go to US Patent

TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM142754(US8937193, 6f)
Affinity DataKd:  2.50E+3nMAssay Description:The synthesized compounds of Formula I may be screened by one-dimensional 1H nuclear magnetic resonance spectroscopy (1D-1H NMR) binding assays again...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2015
Entry Details
Go to US Patent

TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM142756(US8937193, 6i)
Affinity DataKd:  450nMAssay Description:The synthesized compounds of Formula I may be screened by one-dimensional 1H nuclear magnetic resonance spectroscopy (1D-1H NMR) binding assays again...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2015
Entry Details
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TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM31802(Apogossypol | US9115061, Apogossypol)
Affinity DataKd:  1.70E+3nMpH: 7.4Assay Description:Titrations were performed using a VP-ITC or ITC200 calorimeter from Microcal (Northampton, Mass.). BCL-XL was used at concentrations between 25 and 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details
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TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM174838(US9115061, I)
Affinity DataKd:  170nMpH: 7.4Assay Description:Titrations were performed using a VP-ITC or ITC200 calorimeter from Microcal (Northampton, Mass.). BCL-XL was used at concentrations between 25 and 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details
Go to US Patent

TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM174845(US9115061, XII)
Affinity DataKd:  40nMpH: 7.4Assay Description:Titrations were performed using a VP-ITC or ITC200 calorimeter from Microcal (Northampton, Mass.). BCL-XL was used at concentrations between 25 and 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details
Go to US Patent

TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM174843(US9115061, VIII)
Affinity DataKd:  2.75E+3nMpH: 7.4Assay Description:Titrations were performed using a VP-ITC or ITC200 calorimeter from Microcal (Northampton, Mass.). BCL-XL was used at concentrations between 25 and 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details
Go to US Patent

TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50316671((S)-1,(R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl...)
Affinity DataKd:  2.00E+3nMAssay Description:Binding affinity to Bcl-XL by isothermal titration calorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50316672((R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N5-((...)
Affinity DataKd:  2.40E+3nMAssay Description:Binding affinity to Bcl-XL by isothermal titration calorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50339777((R)-N-(7-(4-((4'-chlorobiphenyl-2-yl)methyl)pipera...)
Affinity DataKd:  4.20nMAssay Description:Binding affinity to Bcl-XlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2011
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50020929(CHEMBL3287292)
Affinity DataKd:  38nMAssay Description:Binding affinity to GST-tagged Bcl-Xl (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50020930(CHEMBL3287293)
Affinity DataKd:  10nMAssay Description:Binding affinity to GST-tagged Bcl-Xl (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50020938(CHEMBL3287301)
Affinity DataKd: <5nMAssay Description:Binding affinity to GST-tagged Bcl-Xl (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50030763(CHEMBL3342188)
Affinity DataKd:  4.00E+6nMAssay Description:Binding affinity to BCL-XL (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50270875(5,6,7,8-tetrahydro-1-naphthol | CHEMBL449132)
Affinity DataKd:  4.30E+6nMAssay Description:Inhibition of GST-tagged Bcl-xL (unknown origin) measured after 1 hr incubation by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50060993(4'-Fluoro-biphenyl-4-carboxylic acid | 4'-FLUORO-1...)
Affinity DataKd:  3.00E+5nMAssay Description:Inhibition of GST-tagged Bcl-xL (unknown origin) measured after 1 hr incubation by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50293169(kendomycin | CHEMBL523927)
Affinity DataKd:  5.28E+5nMAssay Description:Inhibition of interaction between GST-tagged Bcl-xl and Bak by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50293170((1R,12S,16S,19R,20R,21S,22R)-4,8,21-Trihydroxy-10-...)
Affinity DataKd:  1.08E+7nMAssay Description:Inhibition of interaction between GST-tagged Bcl-xl and Bak by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50293171((1R,2S,4S,6E,8S,11R,12R,13S,14R,15R,22R)-13-hydrox...)
Affinity DataKd:  3.77E+5nMAssay Description:Inhibition of interaction between GST-tagged Bcl-xl and Bak by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM23223(Tash 1 | Gossypol, 4 | 7-[8-formyl-1,6,7-trihydrox...)
Affinity DataKd:  1.71E+3nMAssay Description:Inhibition of interaction between GST-tagged Bcl-xl and Bak by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50293169(kendomycin | CHEMBL523927)
Affinity DataKd:  1.83E+6nMAssay Description:Inhibition of interaction between Bcl-xl and Bak by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50293171((1R,2S,4S,6E,8S,11R,12R,13S,14R,15R,22R)-13-hydrox...)
Affinity DataKd:  3.99E+5nMAssay Description:Inhibition of interaction between Bcl-xl and Bak by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM23223(Tash 1 | Gossypol, 4 | 7-[8-formyl-1,6,7-trihydrox...)
Affinity DataKd:  3.38E+5nMAssay Description:Inhibition of interaction between Bcl-xl and Bak by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50308551([1,1'-biphenyl]-2-ol | biphenyl-2-ol | o-diphenylo...)
Affinity DataKd:  2.70E+6nMAssay Description:Binding affinity to 6xHis-tagged human Bcl-xLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50318189((Z)-2-(3-((7-(2-Methoxyphenyl)-9-oxo-5H-benzo[h]th...)
Affinity DataKd:  9.50E+3nMAssay Description:Binding affinity to human Bcl-XL by surface plasma resonance based biosensor systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50318190((Z)-3-((2-Methoxy-4-((7-(4-methoxyphenyl)-9-oxo-5H...)
Affinity DataKd:  9.63E+4nMAssay Description:Binding affinity to human Bcl-XL by surface plasma resonance based biosensor systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50318192((Z)-3-(4-((7-(4-Methoxyphenyl)-9-oxo-5H-benzo[h]th...)
Affinity DataKd:  3.85E+4nMAssay Description:Binding affinity to human Bcl-XL by surface plasma resonance based biosensor systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50329368(1,1-bis(4-chlorophenyl)-4-(dimethylamino)butan-1-o...)
Affinity DataKd:  4.50E+5nMAssay Description:Binding affinity to Bcl-XL by NMR titration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50329371(chlorcyclizine | CHEMBL22150 | 1-[(4-Chloro-phenyl...)
Affinity DataKd:  7.00E+5nMAssay Description:Binding affinity to Bcl-XL by NMR titration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50329370(4-(dimethylamino)-1,1-diphenylbutan-1-ol | CHEMBL1...)
Affinity DataKd:  5.00E+6nMAssay Description:Binding affinity to Bcl-XL by NMR titration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50329369((R)-1-(4-chlorophenyl)-4-(dimethylamino)-1-phenylb...)
Affinity DataKd:  5.00E+5nMAssay Description:Binding affinity to Bcl-XL by NMR titration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50330247(6,6',7,7'-Tetrahydroxy-5,5'-diisopropyl-3,3'-dimet...)
Affinity DataKd:  2.80E+3nMAssay Description:Binding affinity Bcl-xL by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50330248(6,6',7,7'-Tetrahydroxy-5,5'-diisobutyl-3,3'-dimeth...)
Affinity DataKd:  1.50E+3nMAssay Description:Binding affinity Bcl-xL by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50330249(6,6',7,7'-Tetrahydroxy-3,3'-dimethyl-5,5'-bis(4-me...)
Affinity DataKd:  2.50E+3nMAssay Description:Binding affinity Bcl-xL by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50330250(5,5'-Dibenzyl-6,6',7,7'-tetrahydroxy-3,3'-dimethyl...)
Affinity DataKd:  450nMAssay Description:Binding affinity Bcl-xL by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM21447(4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1...)
Affinity DataKd:  0.370nMAssay Description:Binding affinity to Bcl-XlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2011
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50060993(4'-Fluoro-biphenyl-4-carboxylic acid | 4'-FLUORO-1...)
Affinity DataKd:  3.00E+5nMAssay Description:Binding affinity to Bcl-xL by 2D- NOESY analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50270875(5,6,7,8-tetrahydro-1-naphthol | CHEMBL449132)
Affinity DataKd:  4.30E+6nMAssay Description:Binding affinity to Bcl-xL by 2D- NOESY analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM13337(3-(benzyloxy)pyridin-2-amine | Pyridine derived fr...)
Affinity DataKd:  6.92E+5nMAssay Description:Binding affinity to Bcl-xL by 2D- NOESY analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50352199(CHEMBL1824799)
Affinity DataKd:  3.78E+5nMAssay Description:Binding affinity to Bcl-xL by 2D- NOESY analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50172738(GQVGRQLAIIGDDINR | CHEMBL441321)
Affinity DataKd:  3.5nMAssay Description:Binding affinity for GST-tagged human wild type Bcl-2-like protein 1 expressed in Escherichia coli BL21 cells at 35 nM Bodipy-labelled compound after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50436625(CHEMBL2398169)
Affinity DataKd:  0.140nMAssay Description:Binding affinity to human GST-tagged Bcl-Xl assessed as dissociation rate by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50436643(CHEMBL2398292 | 3-(5-(1-(2-(Benzo[d]thiazol-2-yl)h...)
Affinity DataKd:  1.20E+4nMAssay Description:Binding affinity to human GST-tagged Bcl-Xl assessed as dissociation rate by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50436643(CHEMBL2398292 | 3-(5-(1-(2-(Benzo[d]thiazol-2-yl)h...)
Affinity DataKd:  9.00E+3nMAssay Description:Binding affinity to human GST-tagged Bcl-Xl assessed as direct binding constant at steady state by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50181876(N-(4'-fluoro-biphenyl-4-carbonyl)-3-nitro-4-(2-phe...)
Affinity DataKd:  1.90E+3nMAssay Description:Binding affinity to human GST-tagged Bcl-Xl assessed as dissociation rate by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50181876(N-(4'-fluoro-biphenyl-4-carbonyl)-3-nitro-4-(2-phe...)
Affinity DataKd:  900nMAssay Description:Binding affinity to human GST-tagged Bcl-Xl assessed as direct binding constant at steady state by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50436648(CHEMBL2398286)
Affinity DataKd:  79nMAssay Description:Binding affinity to human GST-tagged Bcl-Xl assessed as dissociation rate by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50436648(CHEMBL2398286)
Affinity DataKd:  61nMAssay Description:Binding affinity to human GST-tagged Bcl-Xl assessed as direct binding constant at steady state by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM109232(CHEMBL2398173 | 6-(8-(2-(Benzothiazol-2-yl)hydrazo...)
Affinity DataKd:  4.10nMAssay Description:Binding affinity to human GST-tagged Bcl-Xl assessed as dissociation rate by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
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