Compile Data Set for Download or QSAR
Report error Found 153 of kd data for polymerid = 3907
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50509567BDBM50509567(CHEMBL4455382 | US11213520, Example I-003)
Affinity DataKd:  0.770nMAssay Description:Binding affinity to CDK8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 31085BDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd:  1.40nMAssay Description:Binding constant for CDK8 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 31085BDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd:  1.40nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 31085BDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd:  1.40nMAssay Description:Binding constant for CDK8 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50542371BDBM50542371(CHEMBL4637601)
Affinity DataKd:  3.5nMAssay Description:Inhibition of biotinylated ligand binding to wild-type human partial length CDK8 (M1 to T360 residues) expressed in Escherichia coli BL21 measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50542370BDBM50542370(CHEMBL4648955)
Affinity DataKd:  13nMAssay Description:Inhibition of biotinylated ligand binding to wild-type human partial length CDK8 (M1 to T360 residues) expressed in Escherichia coli BL21 measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50542374BDBM50542374(CHEMBL4635162)
Affinity DataKd:  17nMAssay Description:Inhibition of biotinylated ligand binding to wild-type human partial length CDK8 (M1 to T360 residues) expressed in Escherichia coli BL21 measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50542374BDBM50542374(CHEMBL4635162)
Affinity DataKd:  17nMAssay Description:Binding affinity to CDK8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50248631BDBM50248631(CHEMBL4080906)
Affinity DataKd:  17nMAssay Description:Binding affinity to wild-type partial length human CDK8 (M1 to T360 residues) expressed in bacterial expression system by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50248631BDBM50248631(CHEMBL4080906)
Affinity DataKd:  17nMAssay Description:Binding affinity to wild-type partial length human CDK8 (M1 to T360 residues) expressed in bacterial expression system by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50542373BDBM50542373(CHEMBL4637411 | US12325725, Compound 24)
Affinity DataKd:  18nMAssay Description:Inhibition of biotinylated ligand binding to wild-type human partial length CDK8 (M1 to T360 residues) expressed in Escherichia coli BL21 measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50610461BDBM50610461(CHEMBL5270079)
Affinity DataKd:  30nMAssay Description:Binding affinity to CDK8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50509569BDBM50509569(CHEMBL4456001)
Affinity DataKd:  30nMAssay Description:Binding affinity to CDK8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50509568BDBM50509568(CHEMBL4584784)
Affinity DataKd:  32nMAssay Description:Binding affinity to CDK8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50542369BDBM50542369(CHEMBL4633633)
Affinity DataKd:  41nMAssay Description:Inhibition of biotinylated ligand binding to wild-type human partial length CDK8 (M1 to T360 residues) expressed in Escherichia coli BL21 measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50542372BDBM50542372(CHEMBL4646453)
Affinity DataKd:  45nMAssay Description:Inhibition of biotinylated ligand binding to wild-type human partial length CDK8 (M1 to T360 residues) expressed in Escherichia coli BL21 measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50248614BDBM50248614(CHEMBL4066819)
Affinity DataKd:  46nMAssay Description:Binding affinity to partial length wild-type human CDK8 (M1 to T360residues) expressed in bacterial expression system by kinome scan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50585694BDBM50585694(CHEMBL4878072 | US12281080, SCCP 6148)
Affinity DataKd:  55nMAssay Description:Binding affinity to human CDK8 assessed as dissociation constant by KdELECT Discover assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 21079BDBM21079(1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluora...)
Affinity DataKd:  95nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 21079BDBM21079(1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluora...)
Affinity DataKd:  95nMAssay Description:Binding constant for CDK8 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 21079BDBM21079(1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluora...)
Affinity DataKd:  95nMAssay Description:Binding constant for CDK8 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 5655BDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataKd:  120nMAssay Description:Binding constant for CDK8 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 5655BDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataKd:  120nMAssay Description:Binding constant for CDK8 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 31099BDBM31099(CHEMBL45741 | Flavopiridol | cid_24867231 | 2-(2-c...)
Affinity DataKd:  120nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50355504BDBM50355504(CHEMBL1908393)
Affinity DataKd:  130nMAssay Description:Binding constant for CDK8 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50248629BDBM50248629(CHEMBL4076837 | US11471446, Compound DBA-9)
Affinity DataKd:  140nMAssay Description:Inhibition of CDK8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 13533BDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataKd:  220nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 13533BDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataKd:  220nMAssay Description:Binding constant for CDK8 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 13533BDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataKd:  220nMAssay Description:Binding constant for CDK8 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16673BDBM16673(BAY439006 | CHEMBL1336 | BAY 43-9006 | 4-[4-({[4-c...)
Affinity DataKd:  310nMAssay Description:Binding constant for CDK8 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16673BDBM16673(BAY439006 | CHEMBL1336 | BAY 43-9006 | 4-[4-({[4-c...)
Affinity DataKd:  310nMAssay Description:Binding constant for CDK8 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16673BDBM16673(BAY439006 | CHEMBL1336 | BAY 43-9006 | 4-[4-({[4-c...)
Affinity DataKd:  310nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssayPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16673BDBM16673(BAY439006 | CHEMBL1336 | BAY 43-9006 | 4-[4-({[4-c...)
Affinity DataKd:  310nMAssay Description:Binding affinity to CDK8More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  510nMAssay Description:Binding constant for CDK8 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  510nMAssay Description:Binding constant for CDK8 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 31096BDBM31096(CHEMBL290084 | Staurosporine | cid_451705 | US2024...)
Affinity DataKd:  510nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50509570BDBM50509570(CHEMBL4447689)
Affinity DataKd:  600nMAssay Description:Binding affinity to CDK8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50459994BDBM50459994(CHEMBL4226806 | US11471446, Compound DBA-8)
Affinity DataKd:  830nMAssay Description:Binding affinity to wild-type partial length human CDK8 (M1 to T360 residues) expressed in bacterial expression system by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50459994BDBM50459994(CHEMBL4226806 | US11471446, Compound DBA-8)
Affinity DataKd:  830nMAssay Description:Binding affinity to wild-type partial length human CDK8 (M1 to T360 residues) expressed in bacterial expression system by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50532781BDBM50532781(CHEMBL4571241)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to human CDK8More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50532781BDBM50532781(CHEMBL4571241)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to human CDK8More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 5931BDBM5931(cid_3025986 | CHEMBL296468 | N-(5-{[(5-tert-butyl-...)
Affinity DataKd:  1.20E+3nMAssay Description:Binding constant for CDK8 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 5931BDBM5931(cid_3025986 | CHEMBL296468 | N-(5-{[(5-tert-butyl-...)
Affinity DataKd:  1.20E+3nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 5931BDBM5931(cid_3025986 | CHEMBL296468 | N-(5-{[(5-tert-butyl-...)
Affinity DataKd:  1.20E+3nMAssay Description:Binding constant for CDK8 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50560888BDBM50560888(CHEMBL4749646)
Affinity DataKd:  1.40E+3nMAssay Description:Displacement of polymer supported probe 25 binding to CDK8 in human THP-1 cell lysates preincubated for 45 mins under shaking condition followed by p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25617BDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd:  1.90E+3nMAssay Description:Binding constant for CDK8 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 31340BDBM31340(CP-724714 | 2-methoxy-N-[(E)-3-[4-[3-methyl-4-[(6-...)
Affinity DataKd:  2.30E+3nMAssay Description:Binding affinity to wild-type partial length human CDK8 (M1 to T360 residues) expressed in bacterial expression system by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 31340BDBM31340(CP-724714 | 2-methoxy-N-[(E)-3-[4-[3-methyl-4-[(6-...)
Affinity DataKd:  2.30E+3nMAssay Description:Binding constant for CDK8 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 31340BDBM31340(CP-724714 | 2-methoxy-N-[(E)-3-[4-[3-methyl-4-[(6-...)
Affinity DataKd:  2.30E+3nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetCyclin-dependent kinase 8(Human)
University Of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 31340BDBM31340(CP-724714 | 2-methoxy-N-[(E)-3-[4-[3-methyl-4-[(6-...)
Affinity DataKd:  2.30E+3nMAssay Description:Binding affinity to wild-type partial length human CDK8 (M1 to T360 residues) expressed in bacterial expression system by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
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