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Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM645761(US20240018151, Example 24)
Affinity DataKd:  3nMAssay Description:Kinase-tagged T7 phage strains are prepared in an E. coli host derived from the BL21 strain. E. coli are grown to log-phase and infected with T7 phag...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM597631(US11603372, Example 5 | 4-morpholino-2-[(2E)-2-(m-...)
Affinity DataKd:  5.5nMAssay Description:For most assays, kinase-tagged T7 phage strains were prepared in an E. colihost derived from the BL21 strain. E. coli were grown to log-phase and inf...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM597630(US11603372, Example 4 | 4-morpholino-2-[(2E)-2-(m-...)
Affinity DataKd: <1nMAssay Description:For most assays, kinase-tagged T7 phage strains were prepared in an E. colihost derived from the BL21 strain. E. coli were grown to log-phase and inf...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM597629(US11603372, Example 3 | 4-morpholino-N-[(E)-m-toly...)
Affinity DataKd:  5.5nMAssay Description:For most assays, kinase-tagged T7 phage strains were prepared in an E. colihost derived from the BL21 strain. E. coli were grown to log-phase and inf...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM597628(US11603372, Example 2 | 4-morpholino-N-[(E)-m-toly...)
Affinity DataKd: <1nMAssay Description:For most assays, kinase-tagged T7 phage strains were prepared in an E. colihost derived from the BL21 strain. E. coli were grown to log-phase and inf...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM597627(US11603372, Example 1)
Affinity DataKd:  5.5nMAssay Description:For most assays, kinase-tagged T7 phage strains were prepared in an E. colihost derived from the BL21 strain. E. coli were grown to log-phase and inf...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM50590927(Apilimod | Sta-5326 | STA 5326 | STA-5326 | APILIM...)
Affinity DataKd:  0.0750nMAssay Description:Binding affinity to human wild type partial length PIKFYVE (F1512 to C2098 residues) mammalian expression assessed as dissociation constant by Kinome...More data for this Ligand-Target Pair
In DepthDetails
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM645763(US20240018151, Example 28)
Affinity DataKd:  3nMAssay Description:Kinase-tagged T7 phage strains are prepared in an E. coli host derived from the BL21 strain. E. coli are grown to log-phase and infected with T7 phag...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM645762(US20240018151, Example 25)
Affinity DataKd:  7.5nMAssay Description:Kinase-tagged T7 phage strains are prepared in an E. coli host derived from the BL21 strain. E. coli are grown to log-phase and infected with T7 phag...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM597632(US11603372, Example 7 | 4-morpholino-2-[(2E)-2-(m-...)
Affinity DataKd: <1nMAssay Description:For most assays, kinase-tagged T7 phage strains were prepared in an E. colihost derived from the BL21 strain. E. coli were grown to log-phase and inf...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM645760(US20240018151, Example 20)
Affinity DataKd:  7.5nMAssay Description:Kinase-tagged T7 phage strains are prepared in an E. coli host derived from the BL21 strain. E. coli are grown to log-phase and infected with T7 phag...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM645759(US20240018151, Example 19)
Affinity DataKd:  7.5nMAssay Description:Kinase-tagged T7 phage strains are prepared in an E. coli host derived from the BL21 strain. E. coli are grown to log-phase and infected with T7 phag...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM645758(US20240018151, Example 18)
Affinity DataKd:  7.5nMAssay Description:Kinase-tagged T7 phage strains are prepared in an E. coli host derived from the BL21 strain. E. coli are grown to log-phase and infected with T7 phag...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM645744(US20240018151, Example 17 | US20240018151, Example...)
Affinity DataKd:  7.5nMAssay Description:Kinase-tagged T7 phage strains are prepared in an E. coli host derived from the BL21 strain. E. coli are grown to log-phase and infected with T7 phag...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM645749(US20240018151, Example 15 | US20240018151, Example...)
Affinity DataKd:  3nMAssay Description:Kinase-tagged T7 phage strains are prepared in an E. coli host derived from the BL21 strain. E. coli are grown to log-phase and infected with T7 phag...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM645755(US20240018151, Example 14)
Affinity DataKd: <1nMAssay Description:Kinase-tagged T7 phage strains are prepared in an E. coli host derived from the BL21 strain. E. coli are grown to log-phase and infected with T7 phag...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM645754(US20240018151, Example 11)
Affinity DataKd: <1nMAssay Description:Kinase-tagged T7 phage strains are prepared in an E. coli host derived from the BL21 strain. E. coli are grown to log-phase and infected with T7 phag...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM645749(US20240018151, Example 15 | US20240018151, Example...)
Affinity DataKd:  7.5nMAssay Description:Kinase-tagged T7 phage strains are prepared in an E. coli host derived from the BL21 strain. E. coli are grown to log-phase and infected with T7 phag...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM597640(US11603372, Example 261 | 4-morpholino-N-[(E)-m- t...)
Affinity DataKd: <1nMAssay Description:For most assays, kinase-tagged T7 phage strains were prepared in an E. colihost derived from the BL21 strain. E. coli were grown to log-phase and inf...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM557265(US11352354, Example V-c-17)
Affinity DataKd:  6.40nMAssay Description:Binding affinity to PIKFYVE (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM50617126(CHEMBL5413843)
Affinity DataKd:  270nMAssay Description:Binding affinity to wild type partial length human PIKFYVE (F1512 to C2098 residues) expressed in mammalian expression system by KdELECT kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM50617125(CHEMBL5398852)
Affinity DataKd:  5.00E+3nMAssay Description:Binding affinity to wild type partial length human PIKFYVE (F1512 to C2098 residues) expressed in mammalian expression system by KdELECT kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM597645(US11603372, Example 268 | 6-(3,5-dimethyl-1H-pyraz...)
Affinity DataKd:  5.5nMAssay Description:For most assays, kinase-tagged T7 phage strains were prepared in an E. colihost derived from the BL21 strain. E. coli were grown to log-phase and inf...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM597644(US11603372, Example 267 | 6-(3,5-dimethylisoxazol-...)
Affinity DataKd:  5.5nMAssay Description:For most assays, kinase-tagged T7 phage strains were prepared in an E. colihost derived from the BL21 strain. E. coli were grown to log-phase and inf...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM597643(US11603372, Example 264 | 6-(3,5-dimethylisoxazol-...)
Affinity DataKd: <1nMAssay Description:For most assays, kinase-tagged T7 phage strains were prepared in an E. colihost derived from the BL21 strain. E. coli were grown to log-phase and inf...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM597642(US11603372, Example 263 | 6-(3,5-dimethyl-1H-pyraz...)
Affinity DataKd: <1nMAssay Description:For most assays, kinase-tagged T7 phage strains were prepared in an E. colihost derived from the BL21 strain. E. coli were grown to log-phase and inf...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM597641(US11603372, Example 262 | 6-(1-methylpyrazol-4-yl)...)
Affinity DataKd: <1nMAssay Description:For most assays, kinase-tagged T7 phage strains were prepared in an E. colihost derived from the BL21 strain. E. coli were grown to log-phase and inf...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM645744(US20240018151, Example 17 | US20240018151, Example...)
Affinity DataKd:  7.5nMAssay Description:Kinase-tagged T7 phage strains are prepared in an E. coli host derived from the BL21 strain. E. coli are grown to log-phase and infected with T7 phag...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM597639(US11603372, Example 255 | 4-morpholino-N-[2-(m- to...)
Affinity DataKd:  35nMAssay Description:For most assays, kinase-tagged T7 phage strains were prepared in an E. colihost derived from the BL21 strain. E. coli were grown to log-phase and inf...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM597638(US11603372, Example 22 | N-(azetidin-3-yl)-4-morph...)
Affinity DataKd:  5.5nMAssay Description:For most assays, kinase-tagged T7 phage strains were prepared in an E. colihost derived from the BL21 strain. E. coli were grown to log-phase and inf...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM597637(US11603372, Example 14 | N-[(E)-(3-chlorophenyl)me...)
Affinity DataKd:  35nMAssay Description:For most assays, kinase-tagged T7 phage strains were prepared in an E. colihost derived from the BL21 strain. E. coli were grown to log-phase and inf...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM597636(US11603372, Example 12 | 4-morpholino-N-[(E)-m-tol...)
Affinity DataKd: <1nMAssay Description:For most assays, kinase-tagged T7 phage strains were prepared in an E. colihost derived from the BL21 strain. E. coli were grown to log-phase and inf...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM597635(US11603372, Example 11 | 4-morpholino-N-[(E)-m-tol...)
Affinity DataKd:  5.5nMAssay Description:For most assays, kinase-tagged T7 phage strains were prepared in an E. colihost derived from the BL21 strain. E. coli were grown to log-phase and inf...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM597634(US11603372, Example 10 | 4-morpholino-N-[(E)-m-tol...)
Affinity DataKd:  35nMAssay Description:For most assays, kinase-tagged T7 phage strains were prepared in an E. colihost derived from the BL21 strain. E. coli were grown to log-phase and inf...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM597633(US11603372, Example 9 | 4-Morpholino-N-[(E)-m-toly...)
Affinity DataKd:  5.5nMAssay Description:For most assays, kinase-tagged T7 phage strains were prepared in an E. colihost derived from the BL21 strain. E. coli were grown to log-phase and inf...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM557264(US11352354, Example V-c-16)
Affinity DataKd:  1.10E+5nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM557271(US11352354, Example V-c-23)
Affinity DataKd:  3.30E+4nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM557270(US11352354, Example V-c-22)
Affinity DataKd:  2.10E+7nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM557269(US11352354, Example V-c-21)
Affinity DataKd:  9.10E+5nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM557268(US11352354, Example V-c-20)
Affinity DataKd:  1.00E+6nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM557267(US11352354, Example V-c-19)
Affinity DataKd:  1.50E+4nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM557267(US11352354, Example V-c-19)
Affinity DataKd:  1.60E+4nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM557266(US11352354, Example V-c-18)
Affinity DataKd:  6.40E+3nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM557265(US11352354, Example V-c-17)
Affinity DataKd:  6.40E+5nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM557272(US11352354, Example V-c-24)
Affinity DataKd: >3.00E+7nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM557263(US11352354, Example V-c-15)
Affinity DataKd:  1.40E+5nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM557262(US11352354, Example V-c-14)
Affinity DataKd:  2.00E+4nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM557261(US11352354, Example V-c-13)
Affinity DataKd:  1.60E+4nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM557260(US11352354, Example V-c-12)
Affinity DataKd: >3.00E+7nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Tme Therapeutics

US Patent
LigandPNGBDBM557259(US11352354, Example V-c-11)
Affinity DataKd:  7.00E+5nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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