Compile Data Set for Download or QSAR
Report error Found 153 of kd data for polymerid = 6476
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 374713BDBM374713(US10246466, Example 20 | 11-fluoro-14-methyl-6,7,1...)
Affinity DataKd:  0.180nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 374713BDBM374713(US10246466, Example 20 | 11-fluoro-14-methyl-6,7,1...)
Affinity DataKd:  0.180nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50525709BDBM50525709(CHEMBL4555143)
Affinity DataKd:  1.70nMAssay Description:Binding affinity to recombinant human biotinylated and N-terminal DYKDDDDK-tagged TrkB kinase domain (456-822 residues) expressed in sf21 cells asses...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50565310BDBM50565310(CHEMBL4792981)
Affinity DataKd:  3.10nMAssay Description:Binding affinity to wild-type human partial length TRKB (Q547 to G838 residues) expressed in mammalian expression system by Kinomescan method relativ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  3.80nMAssay Description:Binding constant for TRKB kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  3.80nMAssay Description:Binding constant for TRKB kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 31096BDBM31096(CHEMBL290084 | Staurosporine | cid_451705 | US2024...)
Affinity DataKd:  3.80nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details
PCBioAssay
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50355504BDBM50355504(CHEMBL1908393)
Affinity DataKd:  4.10nMAssay Description:Binding constant for TRKB kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50093539BDBM50093539(7,8-dihydroxy-2-phenyl-4H-chromen-4-one | 7,8-Dihy...)
Affinity DataKd:  10nMAssay Description:Binding affinity to recombinant human TrkB receptor ECD assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50368452BDBM50368452(CHEMBL4168305)
Affinity DataKd:  11nMAssay Description:Binding affinity to human TrkBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50308060BDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  14nMAssay Description:Binding affinity to TRKBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50308060BDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  14nMAssay Description:Binding constant for TRKB kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50248946BDBM50248946(CHEMBL1908392 | US10981896, Compound 16 | Nintedan...)
Affinity DataKd:  19nMAssay Description:Binding constant for TRKB kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50528539BDBM50528539(CHEMBL4553037)
Affinity DataKd:  22nMAssay Description:Binding affinity to wild type human partial length TRKB (547 to 838 residues) expressed in mammalian expression system preincubated for 1 hr measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50528539BDBM50528539(CHEMBL4553037)
Affinity DataKd:  22nMAssay Description:Binding affinity to TrkB (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50528539BDBM50528539(CHEMBL4553037)
Affinity DataKd:  22nMAssay Description:Binding affinity to wild type human partial length TRKB (547 to 838 residues) expressed in mammalian expression system preincubated for 1 hr measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50554329BDBM50554329(CHEMBL4646064)
Affinity DataKd:  23nMAssay Description:Binding affinity to human partial length TRKB expressed in mammalian expression system by kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50554331BDBM50554331(CHEMBL4798635)
Affinity DataKd:  28nMAssay Description:Binding affinity to human partial length TRKB expressed in mammalian expression system by kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 32362BDBM32362(cid_11617559 | GW-2580 | 5-[[3-methoxy-4-[(4-metho...)
Affinity DataKd:  36nMAssay Description:Binding constant for TRKB kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 32362BDBM32362(cid_11617559 | GW-2580 | 5-[[3-methoxy-4-[(4-metho...)
Affinity DataKd:  36nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details
PCBioAssayPDB3D3D Structure (crystal)
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50639632BDBM50639632(CHEMBL5562279)
Affinity DataKd:  36nMAssay Description:Binding affinity to TRKB (unknown origin) receptor assessed as dissociation constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 32362BDBM32362(cid_11617559 | GW-2580 | 5-[[3-methoxy-4-[(4-metho...)
Affinity DataKd:  36nMAssay Description:Binding constant for TRKB kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50306682BDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataKd:  37nMAssay Description:Binding constant for TRKB kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50532781BDBM50532781(CHEMBL4571241)
Affinity DataKd:  54nMAssay Description:Binding affinity to human TRKBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50532781BDBM50532781(CHEMBL4571241)
Affinity DataKd:  54nMAssay Description:Binding affinity to human TRKBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50665703BDBM50665703(CHEMBL6175562)
Affinity DataKd:  60nMAssay Description:Binding affinity to TRKB (unknown origin) assessed as dissociation constant by KINOMEscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50554333BDBM50554333(CHEMBL4790500)
Affinity DataKd:  60nMAssay Description:Binding affinity to human partial length TRKB expressed in mammalian expression system by kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50554330BDBM50554330(CHEMBL4742649)
Affinity DataKd:  112nMAssay Description:Binding affinity to human partial length TRKB expressed in mammalian expression system by kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50355499BDBM50355499(CHEMBL1908395 | CHEMBL1908842 | US20250129067, Com...)
Affinity DataKd:  120nMAssay Description:Binding constant for TRKB kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 482158BDBM482158(TAE684 | BDBM50242742)
Affinity DataKd:  130nMAssay Description:Binding constant for TRKB kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50355496BDBM50355496(CHEMBL1908397)
Affinity DataKd:  140nMAssay Description:Binding constant for TRKB kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50665700BDBM50665700(CHEMBL6175165)
Affinity DataKd:  150nMAssay Description:Binding affinity to TRKB (unknown origin) assessed as dissociation constant by KINOMEscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50665702BDBM50665702(CHEMBL6170053)
Affinity DataKd:  180nMAssay Description:Binding affinity to TRKB (unknown origin) assessed as dissociation constant by KINOMEscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50554332BDBM50554332(CHEMBL4779847)
Affinity DataKd:  187nMAssay Description:Binding affinity to human partial length TRKB expressed in mammalian expression system by kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 31085BDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd:  190nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details
PCBioAssay
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 31085BDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd:  190nMAssay Description:Binding constant for TRKB kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 31085BDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd:  190nMAssay Description:Binding constant for TRKB kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 13534BDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataKd:  240nMAssay Description:Binding constant for TRKB kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 13534BDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataKd:  240nMAssay Description:Binding constant for TRKB kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 13534BDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataKd:  240nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details
PCBioAssay
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50326053BDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  310nMAssay Description:Binding constant for TRKB kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50326053BDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  310nMAssay Description:Binding constant for TRKB kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50326053BDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  310nMAssay Description:Binding affinity to TRKBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 31094BDBM31094(PKC-412 | cid_24202429)
Affinity DataKd:  310nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details
PCBioAssay
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50093539BDBM50093539(7,8-dihydroxy-2-phenyl-4H-chromen-4-one | 7,8-Dihy...)
Affinity DataKd:  320nMAssay Description:Binding affinity to TrkB receptor extracellular domain (unknown origin) after 10 mins by liquid Scatchard plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50355501BDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataKd:  360nMAssay Description:Binding constant for TRKB kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50237710BDBM50237710(AMN 107 | AMN107 | 4-methyl-N-[3-(4-methyl-1H-imid...)
Affinity DataKd:  490nMAssay Description:Binding constant for TRKB kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 13533BDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataKd:  570nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details
PCBioAssay
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 13533BDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataKd:  570nMAssay Description:Binding constant for TRKB kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 13533BDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataKd:  570nMAssay Description:Binding constant for TRKB kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
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