Compile Data Set for Download or QSAR
Report error Found 128 of kd data for polymerid = 7498
TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 481157BDBM481157(US10906900, Reference 25a)
Affinity DataKd:  0.490nMAssay Description:Table 6 & 7: Fresh solutions of each test compound (2.5 mM in DMSO) are diluted in PBS pH=7.4 at concentrations between 0.5 nM and 5 μM in the p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent

TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 481157BDBM481157(US10906900, Reference 25a)
Affinity DataKd:  0.490nMAssay Description:Table 6 & 7: Fresh solutions of each test compound (2.5 mM in DMSO) are diluted in PBS pH=7.4 at concentrations between 0.5 nM and 5 μM in the p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent

TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 481149BDBM481149(US10906900, Reference 22a)
Affinity DataKd:  0.530nMAssay Description:Table 6 & 7: Fresh solutions of each test compound (2.5 mM in DMSO) are diluted in PBS pH=7.4 at concentrations between 0.5 nM and 5 μM in the p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent

TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 481149BDBM481149(US10906900, Reference 22a)
Affinity DataKd:  0.530nMAssay Description:Table 6 & 7: Fresh solutions of each test compound (2.5 mM in DMSO) are diluted in PBS pH=7.4 at concentrations between 0.5 nM and 5 μM in the p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent

TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 481158BDBM481158(US10906900, Reference 25b)
Affinity DataKd:  0.730nMAssay Description:Table 6 & 7: Fresh solutions of each test compound (2.5 mM in DMSO) are diluted in PBS pH=7.4 at concentrations between 0.5 nM and 5 μM in the p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent

TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 481153BDBM481153(US10906900, Reference 22f)
Affinity DataKd:  0.790nMAssay Description:Table 6 & 7: Fresh solutions of each test compound (2.5 mM in DMSO) are diluted in PBS pH=7.4 at concentrations between 0.5 nM and 5 μM in the p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent

TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 481156BDBM481156(US10906900, Reference 22d)
Affinity DataKd:  1nMAssay Description:Table 6 & 7: Fresh solutions of each test compound (2.5 mM in DMSO) are diluted in PBS pH=7.4 at concentrations between 0.5 nM and 5 μM in the p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent

TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 50545096BDBM50545096(CHEMBL4637732)
Affinity DataKd:  1nMAssay Description:Binding affinity to human wlid-type alpha-synuclein by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 481156BDBM481156(US10906900, Reference 22d)
Affinity DataKd:  1nMAssay Description:Table 6 & 7: Fresh solutions of each test compound (2.5 mM in DMSO) are diluted in PBS pH=7.4 at concentrations between 0.5 nM and 5 μM in the p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent

TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 481159BDBM481159(US10906900, Reference 25c)
Affinity DataKd:  1.27nMAssay Description:Table 6 & 7: Fresh solutions of each test compound (2.5 mM in DMSO) are diluted in PBS pH=7.4 at concentrations between 0.5 nM and 5 μM in the p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent

TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 481150BDBM481150(US10906900, Reference 22b)
Affinity DataKd:  1.40nMAssay Description:Table 6 & 7: Fresh solutions of each test compound (2.5 mM in DMSO) are diluted in PBS pH=7.4 at concentrations between 0.5 nM and 5 μM in the p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent

TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 481150BDBM481150(US10906900, Reference 22b)
Affinity DataKd:  1.40nMAssay Description:Table 6 & 7: Fresh solutions of each test compound (2.5 mM in DMSO) are diluted in PBS pH=7.4 at concentrations between 0.5 nM and 5 μM in the p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent

TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 481160BDBM481160(US10906900, Reference 28)
Affinity DataKd:  2.40nMAssay Description:Table 6 & 7: Fresh solutions of each test compound (2.5 mM in DMSO) are diluted in PBS pH=7.4 at concentrations between 0.5 nM and 5 μM in the p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent

TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 481160BDBM481160(US10906900, Reference 28)
Affinity DataKd:  2.40nMAssay Description:Table 6 & 7: Fresh solutions of each test compound (2.5 mM in DMSO) are diluted in PBS pH=7.4 at concentrations between 0.5 nM and 5 μM in the p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent

TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 481151BDBM481151(US10906900, Reference 22c)
Affinity DataKd:  3.25nMAssay Description:Table 6 & 7: Fresh solutions of each test compound (2.5 mM in DMSO) are diluted in PBS pH=7.4 at concentrations between 0.5 nM and 5 μM in the p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent

TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 481151BDBM481151(US10906900, Reference 22c)
Affinity DataKd:  3.25nMAssay Description:Table 6 & 7: Fresh solutions of each test compound (2.5 mM in DMSO) are diluted in PBS pH=7.4 at concentrations between 0.5 nM and 5 μM in the p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent

TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 50614060BDBM50614060(CHEMBL5270314)
Affinity DataKd:  3.80nMAssay Description:Binding affinity to C-terminal His6-tagged human Alpha-synuclein fibrils (1 to 97 residues) expressed in Escherichia coli assessed as dissociation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 50545088BDBM50545088(CHEMBL4633757)
Affinity DataKd:  8.20nMAssay Description:Binding affinity to human wlid-type alpha-synuclein by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 50103964BDBM50103964(CHEMBL3593932)
Affinity DataKd:  8.90nMAssay Description:Binding affinity to recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 50582842BDBM50582842(CHEMBL5087695)
Affinity DataKd:  10nMAssay Description:Binding affinity to recombinant human alpha-syn aggregates assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 50545097BDBM50545097(CHEMBL4634055)
Affinity DataKd:  11nMAssay Description:Binding affinity to human wlid-type alpha-synuclein by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 50185987BDBM50185987(2-(1-(6-((2-fluoroethyl)(methyl)amino)naphthalen-2...)
Affinity DataKd:  16.1nMAssay Description:Table 6 & 7: Fresh solutions of each test compound (2.5 mM in DMSO) are diluted in PBS pH=7.4 at concentrations between 0.5 nM and 5 μM in the p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent

TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 50185987BDBM50185987(2-(1-(6-((2-fluoroethyl)(methyl)amino)naphthalen-2...)
Affinity DataKd:  16.1nMAssay Description:Table 6 & 7: Fresh solutions of each test compound (2.5 mM in DMSO) are diluted in PBS pH=7.4 at concentrations between 0.5 nM and 5 μM in the p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent

TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 50492518BDBM50492518(Florbetapir | US10906900, AV45)
Affinity DataKd:  24.3nMAssay Description:Table 6 & 7: Fresh solutions of each test compound (2.5 mM in DMSO) are diluted in PBS pH=7.4 at concentrations between 0.5 nM and 5 μM in the p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent

TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 50492518BDBM50492518(Florbetapir | US10906900, AV45)
Affinity DataKd:  24.3nMAssay Description:Table 6 & 7: Fresh solutions of each test compound (2.5 mM in DMSO) are diluted in PBS pH=7.4 at concentrations between 0.5 nM and 5 μM in the p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent

TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 50614041BDBM50614041(CHEMBL5286480)
Affinity DataKd:  30nMAssay Description:Binding affinity to human recombinant Alpha-synuclein assessed as dissociation constant by fluorometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 50614041BDBM50614041(CHEMBL5286480)
Affinity DataKd:  30nMAssay Description:Binding affinity to human recombinant Alpha-synuclein expressed in Escherichia coli assessed as dissociation constant at 200 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 761674BDBM761674(US12377152, Compound 166124)
Affinity DataKd:  30nMAssay Description:PBB5 competition assay: 2 μM of α-synuclein was incubated with 0.26 μM 2-(4-(2-(methylamino)pyridine-5-yl)-1,3-butadiene-1-yl)benzothiazole-6-ol (PBB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/17/2025
Entry Details
US Patent

TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 50609392BDBM50609392(CHEMBL5276896)
Affinity DataKd:  39nMAssay Description:Binding affinity to human brain alpha-synuclein fibrilMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 50614044BDBM50614044(CHEMBL5283353)
Affinity DataKd:  40nMAssay Description:Binding affinity to Alpha-synuclein (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 761662BDBM761662(US12377152, Compound 166099)
Affinity DataKd:  40nMAssay Description:PBB5 competition assay: 2 μM of α-synuclein was incubated with 0.26 μM 2-(4-(2-(methylamino)pyridine-5-yl)-1,3-butadiene-1-yl)benzothiazole-6-ol (PBB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/17/2025
Entry Details
US Patent

TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 50582831BDBM50582831(CHEMBL5074716)
Affinity DataKd:  40nMAssay Description:Binding affinity to recombinant human alpha-syn aggregates assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 50545098BDBM50545098(CHEMBL4644640)
Affinity DataKd:  47nMAssay Description:Binding affinity to human wlid-type alpha-synuclein by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 50389294BDBM50389294(CHEMBL2063787)
Affinity DataKd:  60nMAssay Description:Binding affinity to recombinant human alpha-syn aggregates assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 761677BDBM761677(US12377152, Compound 177032)
Affinity DataKd:  60nMAssay Description:(A) Expression and purification of recombinant wild-type human α-synuclein: 0.5 mM IPTG was used to induce production of wild type human α-synuclein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/17/2025
Entry Details
US Patent

TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 50610486BDBM50610486(CHEMBL5290387)
Affinity DataKd:  68nMAssay Description:Inhibition of alpha-Synuclein (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 50582846BDBM50582846(CHEMBL5088083)
Affinity DataKd:  70nMAssay Description:Binding affinity to recombinant human alpha-syn aggregates assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 50582840BDBM50582840(CHEMBL5092684)
Affinity DataKd:  100nMAssay Description:Binding affinity to recombinant human alpha-syn aggregates assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 50545087BDBM50545087(CHEMBL4639644)
Affinity DataKd:  105nMAssay Description:Binding affinity to human wlid-type alpha-synuclein by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 50545092BDBM50545092(CHEMBL4642469)
Affinity DataKd:  107nMAssay Description:Binding affinity to human wlid-type alpha-synuclein by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 50545086BDBM50545086(CHEMBL4648610)
Affinity DataKd:  112nMAssay Description:Binding affinity to human wlid-type alpha-synuclein by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 50545090BDBM50545090(CHEMBL4634968)
Affinity DataKd:  116nMAssay Description:Binding affinity to human wlid-type alpha-synuclein by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 50582841BDBM50582841(CHEMBL5075163)
Affinity DataKd:  140nMAssay Description:Binding affinity to recombinant human alpha-syn aggregates assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 50582834BDBM50582834(CHEMBL5086296)
Affinity DataKd:  140nMAssay Description:Binding affinity to recombinant human alpha-syn aggregates assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 50582839BDBM50582839(CHEMBL5072207)
Affinity DataKd:  150nMAssay Description:Binding affinity to recombinant human alpha-syn aggregates assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 50553261BDBM50553261(CHEMBL4763384)
Affinity DataKd:  160nMAssay Description:Binding affinity to human alpha-synuclein (1-140 residues) expressed in Escherichia coli BL21(DE3) assessed as first dissociation constant by mass-sp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 50582827BDBM50582827(CHEMBL5075837)
Affinity DataKd:  180nMAssay Description:Binding affinity to recombinant human alpha-syn aggregates assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 50553260BDBM50553260(CHEMBL4748063)
Affinity DataKd:  190nMAssay Description:Binding affinity to alpha-synuclein (unknown origin) expressed in Escherichia coli BL21(DE3) pLysS by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 761681BDBM761681(US12377152, Compound 166965)
Affinity DataKd:  220nMAssay Description:(A) Expression and purification of recombinant wild-type human α-synuclein: 0.5 mM IPTG was used to induce production of wild type human α-synuclein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/17/2025
Entry Details
US Patent

TargetAlpha-synuclein(Human)
Centre National De La Recherche Scientifique

US Patent
LigandChemical structure of BindingDB Monomer ID 50582851BDBM50582851(CHEMBL5085623)
Affinity DataKd:  250nMAssay Description:Binding affinity to recombinant human alpha-syn aggregates assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
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